CRCGN014_HEPG2_3H:F12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (1s,2s)-2-(1-methyl-2-oxohydrazino)-1-phenyl-1-propanol 19.98 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

53 genes differentially expressed following the CRCGN014_HEPG2_3H:F12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 8.95433
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.71844
STIMATE STIM activating enhancer 4.59076
CHMP6 charged multivesicular body protein 6 4.5793
MYLK myosin light chain kinase 4.56307
CSK c-src tyrosine kinase 4.21878
PPARG peroxisome proliferator-activated receptor gamma 4.15215
IDE insulin-degrading enzyme 4.03529
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.34989
MOK MOK protein kinase 3.30723
UBE2A ubiquitin-conjugating enzyme E2A 3.20457
DYNLT3 dynein, light chain, Tctex-type 3 2.92034
ADAM10 ADAM metallopeptidase domain 10 2.82772
CYCS cytochrome c, somatic 2.79843
GPATCH8 G patch domain containing 8 2.66891
CDC45 cell division cycle 45 2.65191
ICMT isoprenylcysteine carboxyl methyltransferase 2.62723
PARP2 poly (ADP-ribose) polymerase 2 2.56717
TEX10 testis expressed 10 2.37141
TLR4 toll-like receptor 4 2.36783
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.35165
GPER1 G protein-coupled estrogen receptor 1 2.31227
LY6D lymphocyte antigen 6 complex, locus D 2.22459
MCUR1 mitochondrial calcium uniporter regulator 1 2.19833
SLURP1 secreted LY6/PLAUR domain containing 1 2.17062
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 2.15963
SSBP2 single-stranded DNA binding protein 2 2.12966
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.08751
MYH2 myosin, heavy chain 2, skeletal muscle, adult 2.07045
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.04177
SPINK5 serine peptidase inhibitor, Kazal type 5 2.02181

decreased expression

Symbol Name Standardized Value
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -9.23399
CCNB2 cyclin B2 -5.10134
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.06538
TRIB3 tribbles pseudokinase 3 -4.96028
NT5DC2 5'-nucleotidase domain containing 2 -4.51946
LDHD lactate dehydrogenase D -4.46465
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.45456
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.25069
CDC25B cell division cycle 25B -4.03802
EIF5 eukaryotic translation initiation factor 5 -3.99634
ZNF586 zinc finger protein 586 -3.89311
PECR peroxisomal trans-2-enoyl-CoA reductase -3.63321
FGFR4 fibroblast growth factor receptor 4 -3.59922
GNAS GNAS complex locus -3.14602
SNX11 sorting nexin 11 -3.10402
NRIP1 nuclear receptor interacting protein 1 -2.99791
OXA1L oxidase (cytochrome c) assembly 1-like -2.86658
EXT1 exostosin glycosyltransferase 1 -2.79475
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.49027
HSPA8 heat shock 70kDa protein 8 -2.2846
CHERP calcium homeostasis endoplasmic reticulum protein -2.11284
DERA deoxyribose-phosphate aldolase (putative) -2.05463