CRCGN014_HEPG2_3H:F15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description c.i. acid red 114 40.2 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

37 genes differentially expressed following the CRCGN014_HEPG2_3H:F15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 6.77546
CXCL2 chemokine (C-X-C motif) ligand 2 3.73351
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.53995
UBQLN2 ubiquilin 2 3.47608
STIMATE STIM activating enhancer 3.41252
ABHD6 abhydrolase domain containing 6 3.38178
NOSIP nitric oxide synthase interacting protein 3.34595
AMDHD2 amidohydrolase domain containing 2 3.30184
CSK c-src tyrosine kinase 3.11754
KIF14 kinesin family member 14 2.85169
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.33205
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.32355
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.29694
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.2858
CBR3 carbonyl reductase 3 2.28044
BMP4 bone morphogenetic protein 4 2.21802
SYNE2 spectrin repeat containing, nuclear envelope 2 2.0723
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.07008
GRB10 growth factor receptor-bound protein 10 2.0643
PNKP polynucleotide kinase 3'-phosphatase 2.0216

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -9.89098
CCNB2 cyclin B2 -6.36968
GNAS GNAS complex locus -4.7581
OXA1L oxidase (cytochrome c) assembly 1-like -4.52342
CD320 CD320 molecule -3.50985
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.50511
TBC1D31 TBC1 domain family, member 31 -3.49714
ZDHHC6 zinc finger, DHHC-type containing 6 -3.20924
ANKRD10 ankyrin repeat domain 10 -2.86044
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.83894
LAP3 leucine aminopeptidase 3 -2.81344
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.57714
PARP2 poly (ADP-ribose) polymerase 2 -2.54642
NT5DC2 5'-nucleotidase domain containing 2 -2.50598
ACR acrosin -2.30208
TSKU tsukushi, small leucine rich proteoglycan -2.23102
HMOX1 heme oxygenase 1 -2.22359