CRCGN014_HEPG2_3H:F17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description thiram 39.6 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

347 genes differentially expressed following the CRCGN014_HEPG2_3H:F17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HSPA1A heat shock 70kDa protein 1A 10.0
DDIT4 DNA-damage-inducible transcript 4 9.1073
BAG3 BCL2-associated athanogene 3 7.72412
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.86515
HMOX1 heme oxygenase 1 5.79985
BZW2 basic leucine zipper and W2 domains 2 5.63037
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 5.41224
EGR1 early growth response 1 5.29682
KIFBP kinesin family binding protein 5.25349
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 4.9404
BTK Bruton agammaglobulinemia tyrosine kinase 4.5713
C2CD2 C2 calcium-dependent domain containing 2 4.49587
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 4.47172
MSRA methionine sulfoxide reductase A 4.40447
LPAR2 lysophosphatidic acid receptor 2 4.08743
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.98457
IL1B interleukin 1, beta 3.98415
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.95469
HSPA1B heat shock 70kDa protein 1B 3.83299
NPDC1 neural proliferation, differentiation and control, 1 3.72773
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 3.70278
MEST mesoderm specific transcript 3.545
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 3.47275
CGRRF1 cell growth regulator with ring finger domain 1 3.42008
JUN jun proto-oncogene 3.40617
TXNL4B thioredoxin-like 4B 3.38856
TRAPPC6A trafficking protein particle complex 6A 3.38006
CAB39L calcium binding protein 39-like 3.37688
UBE2L6 ubiquitin-conjugating enzyme E2L 6 3.33501
FAIM Fas apoptotic inhibitory molecule 3.21434
IER5 immediate early response 5 3.18464
RAB21 RAB21, member RAS oncogene family 3.15053
HTRA1 HtrA serine peptidase 1 3.13878
GSTZ1 glutathione S-transferase zeta 1 3.13086
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 3.1215
CCNA1 cyclin A1 3.1137
CAPN1 calpain 1, (mu/I) large subunit 3.09162
ZFP36 ZFP36 ring finger protein 2.98874
PRKCH protein kinase C, eta 2.98212
NOSIP nitric oxide synthase interacting protein 2.96582
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.96135
BPHL biphenyl hydrolase-like (serine hydrolase) 2.95487
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.93342
JMJD6 jumonji domain containing 6 2.92603
H2BC12 H2B clustered histone 12 2.90275
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.89658
ALAS1 5'-aminolevulinate synthase 1 2.88859
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.88425
SOX2 SRY (sex determining region Y)-box 2 2.83779
CHN1 chimerin 1 2.83701
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 2.80152
SMNDC1 survival motor neuron domain containing 1 2.79849
PTPRK protein tyrosine phosphatase, receptor type, K 2.79288
DENND2D DENN/MADD domain containing 2D 2.78991
NOTCH1 notch 1 2.78418
MYLK myosin light chain kinase 2.7695
HABP2 hyaluronan binding protein 2 2.7521
ADRB2 adrenoceptor beta 2, surface 2.7383
NVL nuclear VCP-like 2.7343
PRKX protein kinase, X-linked 2.70939
RTN2 reticulon 2 2.70812
TDRD12 tudor domain containing 12 2.70439
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.70218
RAI14 retinoic acid induced 14 2.66553
BAMBI BMP and activin membrane-bound inhibitor 2.65836
LY6G5C lymphocyte antigen 6 complex, locus G5C 2.64722
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.632
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 2.61214
DOC2A double C2-like domains, alpha 2.60227
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 2.57617
ARC activity-regulated cytoskeleton-associated protein 2.56661
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 2.56299
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.56226
ANKRD49 ankyrin repeat domain 49 2.55919
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.55293
TREM1 triggering receptor expressed on myeloid cells 1 2.5503
TES testin LIM domain protein 2.54786
TEX11 testis expressed 11 2.54711
RFPL3 ret finger protein-like 3 2.54458
BRSK2 BR serine/threonine kinase 2 2.53411
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.53388
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.5011
TESK1 testis-specific kinase 1 2.48994
FJX1 four jointed box 1 (Drosophila) 2.4832
TRIM13 tripartite motif containing 13 2.48043
DUSP8 dual specificity phosphatase 8 2.47581
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 2.47278
CORO1A coronin, actin binding protein, 1A 2.46324
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.46232
CIAO3 cytosolic iron-sulfur assembly component 3 2.44919
ATP11B ATPase, class VI, type 11B 2.43977
GPATCH2L G patch domain containing 2-like 2.43764
HPSE heparanase 2.41672
TERT telomerase reverse transcriptase 2.41216
SOCS2 suppressor of cytokine signaling 2 2.40833
PDE9A phosphodiesterase 9A 2.40491
CA7 carbonic anhydrase VII 2.39504
GNLY granulysin 2.39371
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.37675
H2BC3 H2B clustered histone 3 2.36772
FCHO1 FCH domain only 1 2.36573
EED embryonic ectoderm development 2.36498
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 2.36136
AMOTL2 angiomotin like 2 2.35893
IGFBP3 insulin-like growth factor binding protein 3 2.35077
PTK2 protein tyrosine kinase 2 2.34295
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.34223
ZBTB18 zinc finger and BTB domain containing 18 2.33879
GHR growth hormone receptor 2.33671
EYA3 EYA transcriptional coactivator and phosphatase 3 2.32947
KCNMB4 potassium channel subfamily M regulatory beta subunit 4 2.31965
MT1E metallothionein 1E 2.31813
JAG2 jagged 2 2.30885
HSPA6 heat shock 70kDa protein 6 (HSP70B') 2.28584
IPO13 importin 13 2.2848
FRS2 fibroblast growth factor receptor substrate 2 2.28132
CYCS cytochrome c, somatic 2.27546
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 2.27336
MT1F metallothionein 1F 2.26748
KITLG KIT ligand 2.26111
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.25885
ATF3 activating transcription factor 3 2.24613
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 2.24549
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5 2.24375
ARL4C ADP-ribosylation factor-like 4C 2.23889
GPR63 G protein-coupled receptor 63 2.2368
SORBS3 sorbin and SH3 domain containing 3 2.2342
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 2.2338
DGKB diacylglycerol kinase, beta 90kDa 2.23085
CRX cone-rod homeobox 2.22987
MUC1 mucin 1, cell surface associated 2.22843
MYOZ3 myozenin 3 2.22542
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) 2.21589
SLFN12 schlafen family member 12 2.21568
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 2.21547
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 2.20727
NGRN neugrin, neurite outgrowth associated 2.20326
KLHDC8A kelch domain containing 8A 2.20263
CD9 CD9 molecule 2.20125
CCRL2 chemokine (C-C motif) receptor-like 2 2.20074
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 2.1847
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.18441
WNT7B wingless-type MMTV integration site family, member 7B 2.17481
TPST2 tyrosylprotein sulfotransferase 2 2.17442
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.17158
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 2.17007
TYROBP TYRO protein tyrosine kinase binding protein 2.16956
UFD1 ubiquitin recognition factor in ER associated degradation 1 2.16687
CLDN7 claudin 7 2.16659
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) 2.16242
PRAMEF10 PRAME family member 10 2.16152
SCN8A sodium channel, voltage gated, type VIII alpha subunit 2.1593
ILK integrin-linked kinase 2.15763
LYRM4 LYR motif containing 4 2.15354
LIN37 lin-37 DREAM MuvB core complex component 2.15079
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1 2.15067
UST uronyl-2-sulfotransferase 2.14943
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 2.14915
GOLT1B golgi transport 1B 2.1488
PUDP pseudouridine 5'-phosphatase 2.12527
TIMP2 TIMP metallopeptidase inhibitor 2 2.11524
DENND1B DENN/MADD domain containing 1B 2.11206
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 2.10826
CRYGA crystallin, gamma A 2.1075
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 2.10035
NXF3 nuclear RNA export factor 3 2.09612
PTMS parathymosin 2.09581
KIF20A kinesin family member 20A 2.08879
LOXL1 lysyl oxidase-like 1 2.07804
NCS1 neuronal calcium sensor 1 2.06982
CRABP2 cellular retinoic acid binding protein 2 2.06899
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 2.0681
MYLIP myosin regulatory light chain interacting protein 2.06776
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 2.05952
STK10 serine/threonine kinase 10 2.04406
TNF tumor necrosis factor 2.04148
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.04123
FAM131B family with sequence similarity 131, member B 2.03993
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 2.03829
KLRB1 killer cell lectin-like receptor subfamily B, member 1 2.03647
LYN LYN proto-oncogene, Src family tyrosine kinase 2.03643
CRYBB1 crystallin, beta B1 2.03638
TENT4A terminal nucleotidyltransferase 4A 2.03338
CCDC30 coiled-coil domain containing 30 2.02983
TBXA2R thromboxane A2 receptor 2.02953
KIAA1614 KIAA1614 2.02913
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 2.02596
ZBTB39 zinc finger and BTB domain containing 39 2.02481
PLSCR1 phospholipid scramblase 1 2.02365
OR51E2 olfactory receptor, family 51, subfamily E, member 2 2.02208
OR2C1 olfactory receptor, family 2, subfamily C, member 1 2.02035
CCL1 chemokine (C-C motif) ligand 1 2.02009
RHBDF1 rhomboid 5 homolog 1 (Drosophila) 2.01581
HIKESHI heat shock protein nuclear import factor hikeshi 2.01424
MMP13 matrix metallopeptidase 13 2.0134
FRMPD4 FERM and PDZ domain containing 4 2.01334
TSC22D3 TSC22 domain family, member 3 2.01274
ATG5 autophagy related 5 2.01241
ZBTB7C zinc finger and BTB domain containing 7C 2.00777
LYZL6 lysozyme-like 6 2.00396
H2BC21 H2B clustered histone 21 2.00308
AMH anti-Mullerian hormone 2.00135

decreased expression

Symbol Name Standardized Value
VAT1 vesicle amine transport 1 -8.15365
DSG2 desmoglein 2 -5.44616
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -5.24238
ZDHHC6 zinc finger, DHHC-type containing 6 -4.99884
GNAS GNAS complex locus -4.9604
SLC35F2 solute carrier family 35, member F2 -4.85706
SKIC2 SKI2 subunit of superkiller complex -4.7917
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.5122
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.4477
LDHD lactate dehydrogenase D -4.22262
TM9SF3 transmembrane 9 superfamily member 3 -4.20212
FBXO7 F-box protein 7 -4.08766
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -4.05705
ETFB electron-transfer-flavoprotein, beta polypeptide -4.05667
STK25 serine/threonine kinase 25 -3.98366
PRCP prolylcarboxypeptidase (angiotensinase C) -3.79421
PCNA proliferating cell nuclear antigen -3.77351
TM9SF2 transmembrane 9 superfamily member 2 -3.62014
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.52903
EIF5 eukaryotic translation initiation factor 5 -3.52492
PCCB propionyl CoA carboxylase, beta polypeptide -3.49979
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.47257
ACAA1 acetyl-CoA acyltransferase 1 -3.425
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -3.4248
INTS3 integrator complex subunit 3 -3.35296
ZMIZ1 zinc finger, MIZ-type containing 1 -3.33594
LGMN legumain -3.23037
CHPT1 choline phosphotransferase 1 -3.059
CD320 CD320 molecule -3.04582
AKAP8 A kinase (PRKA) anchor protein 8 -2.99743
MLEC malectin -2.9905
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.97787
BLCAP bladder cancer associated protein -2.97768
DDB2 damage-specific DNA binding protein 2, 48kDa -2.96808
GRWD1 glutamate-rich WD repeat containing 1 -2.96225
TXLNA taxilin alpha -2.92562
PSIP1 PC4 and SFRS1 interacting protein 1 -2.91965
CHERP calcium homeostasis endoplasmic reticulum protein -2.90803
RBM6 RNA binding motif protein 6 -2.89878
NUP43 nucleoporin 43kDa -2.88992
C2CD5 C2 calcium-dependent domain containing 5 -2.88677
HEATR1 HEAT repeat containing 1 -2.85673
TSKU tsukushi, small leucine rich proteoglycan -2.85651
ZNF586 zinc finger protein 586 -2.83231
PNKP polynucleotide kinase 3'-phosphatase -2.79421
LBR lamin B receptor -2.79417
CDC20 cell division cycle 20 -2.75932
GET1 guided entry of tail-anchored proteins factor 1 -2.73597
CDC25B cell division cycle 25B -2.72199
AMDHD2 amidohydrolase domain containing 2 -2.71748
GAA glucosidase, alpha; acid -2.70267
PUF60 poly-U binding splicing factor 60KDa -2.68339
NISCH nischarin -2.66859
CIRBP cold inducible RNA binding protein -2.6596
TRAPPC3 trafficking protein particle complex 3 -2.63844
PNPLA6 patatin-like phospholipase domain containing 6 -2.63824
GLOD4 glyoxalase domain containing 4 -2.62993
AFG3L2 AFG3-like AAA ATPase 2 -2.61752
COG7 component of oligomeric golgi complex 7 -2.59496
TSPAN4 tetraspanin 4 -2.58987
TATDN2 TatD DNase domain containing 2 -2.56041
TTC31 tetratricopeptide repeat domain 31 -2.55127
DCPS decapping enzyme, scavenger -2.54784
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.49229
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -2.48043
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.47565
MAPK13 mitogen-activated protein kinase 13 -2.46494
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B -2.45831
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.45761
XPC xeroderma pigmentosum, complementation group C -2.45673
RBBP4 retinoblastoma binding protein 4 -2.44576
KHDC4 KH domain containing 4, pre-mRNA splicing factor -2.4397
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase -2.43276
GOLGA8A golgin A8 family, member A -2.42458
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.41012
RAP1GAP RAP1 GTPase activating protein -2.38038
RPIA ribose 5-phosphate isomerase A -2.37833
TOP2B topoisomerase (DNA) II beta 180kDa -2.37471
U2SURP U2 snRNP-associated SURP domain containing -2.37062
MARCKSL1 MARCKS-like 1 -2.36762
ANO10 anoctamin 10 -2.35217
FCHSD2 FCH and double SH3 domains 2 -2.35201
PRPF4 pre-mRNA processing factor 4 -2.34355
PROS1 protein S (alpha) -2.30876
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.30259
CHMP6 charged multivesicular body protein 6 -2.29811
TYK2 tyrosine kinase 2 -2.29087
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.29007
MAT2A methionine adenosyltransferase II, alpha -2.28377
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -2.27222
SMC4 structural maintenance of chromosomes 4 -2.26749
NNT nicotinamide nucleotide transhydrogenase -2.26736
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta -2.26589
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.26565
FSTL3 follistatin-like 3 (secreted glycoprotein) -2.25755
EEIG1 estrogen-induced osteoclastogenesis regulator 1 -2.25739
RNF220 ring finger protein 220 -2.25739
CHEK1 checkpoint kinase 1 -2.25459
TRAP1 TNF receptor-associated protein 1 -2.24668
PEBP1 phosphatidylethanolamine binding protein 1 -2.24532
ICAM3 intercellular adhesion molecule 3 -2.24085
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.23194
DENR density-regulated protein -2.22369
STAT1 signal transducer and activator of transcription 1, 91kDa -2.22203
SRSF9 serine/arginine-rich splicing factor 9 -2.21935
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -2.21047
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) -2.20569
MRPS2 mitochondrial ribosomal protein S2 -2.20541
LRP10 low density lipoprotein receptor-related protein 10 -2.18875
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.18831
GALE UDP-galactose-4-epimerase -2.17283
CCNB1 cyclin B1 -2.16998
MRPL23 mitochondrial ribosomal protein L23 -2.13689
DAPL1 death associated protein-like 1 -2.13173
ENOSF1 enolase superfamily member 1 -2.13086
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -2.11962
TCERG1 transcription elongation regulator 1 -2.10734
TBC1D3G TBC1 domain family member 3G -2.10725
SNX17 sorting nexin 17 -2.10249
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 -2.10037
BLMH bleomycin hydrolase -2.09751
ODAM odontogenic, ameloblast asssociated -2.09442
CDK5RAP1 CDK5 regulatory subunit associated protein 1 -2.08694
WDR7 WD repeat domain 7 -2.08272
USF2 upstream transcription factor 2, c-fos interacting -2.07942
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 -2.06789
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.06567
IGHMBP2 immunoglobulin mu binding protein 2 -2.05892
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.0571
CH25H cholesterol 25-hydroxylase -2.04695
HNRNPR heterogeneous nuclear ribonucleoprotein R -2.04578
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -2.03945
SPAG7 sperm associated antigen 7 -2.03886
NFS1 NFS1 cysteine desulfurase -2.03663
MALT1 MALT1 paracaspase -2.03416
SLC35H1 solute carrier family 35 member H1 -2.032
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.0315
TTI1 TELO2 interacting protein 1 -2.03116
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.02905
AGBL5 ATP/GTP binding protein-like 5 -2.02586
CDK4 cyclin-dependent kinase 4 -2.01766
IQCB1 IQ motif containing B1 -2.01712
OXA1L oxidase (cytochrome c) assembly 1-like -2.01166
TLCD3A TLC domain containing 3A -2.00688
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -2.00641