| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | rotenone 40.4 um perturbation at 3 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
| Downloads & Tools |
147 genes differentially expressed following the CRCGN014_HEPG2_3H:F21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGR1 | early growth response 1 | 6.62453 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 6.43465 |
| ZFP36 | ZFP36 ring finger protein | 6.10148 |
| HSPA1A | heat shock 70kDa protein 1A | 5.94772 |
| STIMATE | STIM activating enhancer | 5.91824 |
| PRR15L | proline rich 15-like | 5.34598 |
| JUN | jun proto-oncogene | 5.20335 |
| IER3 | immediate early response 3 | 4.8042 |
| GSTZ1 | glutathione S-transferase zeta 1 | 4.57979 |
| MAP7 | microtubule-associated protein 7 | 4.55368 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 4.52855 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 4.45497 |
| DDIT4 | DNA-damage-inducible transcript 4 | 4.34642 |
| TEX10 | testis expressed 10 | 4.32476 |
| JADE2 | jade family PHD finger 2 | 4.16303 |
| EDN1 | endothelin 1 | 4.10197 |
| FOSL1 | FOS-like antigen 1 | 4.064 |
| STAP2 | signal transducing adaptor family member 2 | 3.97431 |
| E2F2 | E2F transcription factor 2 | 3.88314 |
| NOTCH1 | notch 1 | 3.79072 |
| STK10 | serine/threonine kinase 10 | 3.77566 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 3.71478 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 3.68643 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 3.52606 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 3.49639 |
| TRIB1 | tribbles pseudokinase 1 | 3.47583 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 3.29109 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 3.27482 |
| AMDHD2 | amidohydrolase domain containing 2 | 3.248 |
| MEST | mesoderm specific transcript | 3.17273 |
| IER2 | immediate early response 2 | 3.15079 |
| CSK | c-src tyrosine kinase | 3.07705 |
| TCFL5 | transcription factor-like 5 (basic helix-loop-helix) | 2.98452 |
| ATF3 | activating transcription factor 3 | 2.96934 |
| LCN2 | lipocalin 2 | 2.9068 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 2.87727 |
| BZW2 | basic leucine zipper and W2 domains 2 | 2.83774 |
| PPARG | peroxisome proliferator-activated receptor gamma | 2.82232 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 2.79605 |
| ZNF589 | zinc finger protein 589 | 2.73235 |
| HYOU1 | hypoxia up-regulated 1 | 2.65766 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 2.64427 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 2.61355 |
| CYCS | cytochrome c, somatic | 2.59538 |
| CLDN4 | claudin 4 | 2.54345 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 2.53448 |
| DDX42 | DEAD (Asp-Glu-Ala-Asp) box helicase 42 | 2.52692 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 2.5238 |
| KDM5A | lysine (K)-specific demethylase 5A | 2.51646 |
| UFM1 | ubiquitin-fold modifier 1 | 2.4895 |
| DTX2 | deltex 2, E3 ubiquitin ligase | 2.4794 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | 2.45376 |
| CLK3 | CDC-like kinase 3 | 2.44991 |
| VGLL4 | vestigial-like family member 4 | 2.44725 |
| GSK3B | glycogen synthase kinase 3 beta | 2.43655 |
| FHL2 | four and a half LIM domains 2 | 2.41907 |
| HAAO | 3-hydroxyanthranilate 3,4-dioxygenase | 2.40398 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 2.38946 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 2.35443 |
| SOX4 | SRY (sex determining region Y)-box 4 | 2.34911 |
| LOC127933115 | uncharacterized LOC127933115 | 2.27072 |
| EGR3 | early growth response 3 | 2.23646 |
| CNPY3 | canopy FGF signaling regulator 3 | 2.21295 |
| KIFBP | kinesin family binding protein | 2.19504 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 | 2.18602 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 2.13915 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 2.13777 |
| EDC3 | enhancer of mRNA decapping 3 | 2.13171 |
| KRT9 | keratin 9, type I | 2.11857 |
| BARX1 | BARX homeobox 1 | 2.1016 |
| ARHGEF16 | Rho guanine nucleotide exchange factor (GEF) 16 | 2.09217 |
| ATXN3 | ataxin 3 | 2.0625 |
| DUSP2 | dual specificity phosphatase 2 | 2.04889 |
| SPAG1 | sperm associated antigen 1 | 2.04363 |
| MICA | MHC class I polypeptide-related sequence A | 2.041 |
| BBX | bobby sox homolog (Drosophila) | 2.02291 |
| BAMBI | BMP and activin membrane-bound inhibitor | 2.01387 |
| C8G | complement component 8, gamma polypeptide | 2.01301 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PCNA | proliferating cell nuclear antigen | -10.0 |
| FASTKD5 | FAST kinase domains 5 | -8.57233 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -6.92355 |
| LDHD | lactate dehydrogenase D | -6.70177 |
| ZNF586 | zinc finger protein 586 | -5.91462 |
| GNAS | GNAS complex locus | -5.23234 |
| GET1 | guided entry of tail-anchored proteins factor 1 | -4.55788 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -4.41136 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -4.29835 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -4.12233 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -4.073 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -4.03781 |
| CD320 | CD320 molecule | -4.01753 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -3.853 |
| TUBB6 | tubulin, beta 6 class V | -3.77999 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -3.71074 |
| CCNB1 | cyclin B1 | -3.3985 |
| CHMP4B | charged multivesicular body protein 4B | -3.28784 |
| CCNB2 | cyclin B2 | -3.07795 |
| ISOC1 | isochorismatase domain containing 1 | -3.03809 |
| NOP56 | NOP56 ribonucleoprotein | -3.03649 |
| BLCAP | bladder cancer associated protein | -3.02596 |
| CDC25B | cell division cycle 25B | -2.937 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -2.83068 |
| ANKRD10 | ankyrin repeat domain 10 | -2.72024 |
| TXLNA | taxilin alpha | -2.68711 |
| IDH3B | isocitrate dehydrogenase 3 (NAD+) beta | -2.67311 |
| TMEM230 | transmembrane protein 230 | -2.61892 |
| ACTMAP | actin maturation protease | -2.59484 |
| NISCH | nischarin | -2.5852 |
| GYS1 | glycogen synthase 1 (muscle) | -2.55534 |
| TLCD3A | TLC domain containing 3A | -2.55385 |
| CENPB | centromere protein B, 80kDa | -2.52114 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -2.46365 |
| MAT2A | methionine adenosyltransferase II, alpha | -2.45642 |
| ITGA7 | integrin, alpha 7 | -2.42361 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -2.4219 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -2.41637 |
| CDK1 | cyclin-dependent kinase 1 | -2.41184 |
| DDRGK1 | DDRGK domain containing 1 | -2.40762 |
| SNRPB2 | small nuclear ribonucleoprotein polypeptide B | -2.37153 |
| MEGF8 | multiple EGF-like-domains 8 | -2.34501 |
| SOX12 | SRY (sex determining region Y)-box 12 | -2.33928 |
| MAVS | mitochondrial antiviral signaling protein | -2.31516 |
| SNRPB | small nuclear ribonucleoprotein polypeptides B and B1 | -2.31103 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | -2.3079 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | -2.24244 |
| TUBA1C | tubulin, alpha 1c | -2.21339 |
| NDUFS2 | NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) | -2.20908 |
| POGLUT1 | protein O-glucosyltransferase 1 | -2.19841 |
| SMARCD3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 | -2.19295 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -2.1887 |
| TRMT61B | tRNA methyltransferase 61B | -2.18027 |
| MEMO1 | mediator of cell motility 1 | -2.13712 |
| DHTKD1 | dehydrogenase E1 and transketolase domain containing 1 | -2.13365 |
| TCTN1 | tectonic family member 1 | -2.1323 |
| CDS2 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 | -2.12724 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -2.12017 |
| PFAS | phosphoribosylformylglycinamidine synthase | -2.10888 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | -2.09368 |
| HRC | histidine rich calcium binding protein | -2.07289 |
| SAMM50 | SAMM50 sorting and assembly machinery component | -2.07056 |
| UBE3C | ubiquitin protein ligase E3C | -2.07034 |
| KIF3B | kinesin family member 3B | -2.06333 |
| DPP8 | dipeptidyl-peptidase 8 | -2.05551 |
| TUBA1B | tubulin, alpha 1b | -2.03166 |
| YME1L1 | YME1-like 1 ATPase | -2.02242 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -2.0098 |
| PSMG1 | proteasome (prosome, macropain) assembly chaperone 1 | -2.00357 |
