| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | clotrimazole 20.56 um perturbation at 3 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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221 genes differentially expressed following the CRCGN014_HEPG2_3H:F22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DDIT4 | DNA-damage-inducible transcript 4 | 10.0 |
| HSPA1A | heat shock 70kDa protein 1A | 10.0 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 8.20751 |
| BAG3 | BCL2-associated athanogene 3 | 7.86674 |
| EGR1 | early growth response 1 | 7.64597 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 6.77302 |
| ZFP36 | ZFP36 ring finger protein | 6.02014 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 6.00718 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 5.86643 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 5.78757 |
| JUN | jun proto-oncogene | 5.75509 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 5.46709 |
| HSPA1B | heat shock 70kDa protein 1B | 5.11274 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 4.86336 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 4.7111 |
| KIFBP | kinesin family binding protein | 4.49664 |
| HSPB1 | heat shock 27kDa protein 1 | 4.4395 |
| UBQLN2 | ubiquilin 2 | 4.01371 |
| FOSL1 | FOS-like antigen 1 | 3.99612 |
| TRIB1 | tribbles pseudokinase 1 | 3.96829 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 3.84633 |
| FRS2 | fibroblast growth factor receptor substrate 2 | 3.83286 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 3.83253 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | 3.80584 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 3.8001 |
| IER2 | immediate early response 2 | 3.78187 |
| STX1A | syntaxin 1A (brain) | 3.63109 |
| LOC128125814 | uncharacterized LOC128125814 | 3.49909 |
| CNPY3 | canopy FGF signaling regulator 3 | 3.49604 |
| PMM2 | phosphomannomutase 2 | 3.37178 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 3.35932 |
| ATF3 | activating transcription factor 3 | 3.35473 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 3.33244 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 3.22371 |
| ICAM1 | intercellular adhesion molecule 1 | 3.2217 |
| CHN1 | chimerin 1 | 3.1083 |
| EPHB2 | EPH receptor B2 | 3.02696 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 2.8893 |
| TSC22D1 | TSC22 domain family, member 1 | 2.85638 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 2.84969 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 2.84543 |
| PLK3 | polo-like kinase 3 | 2.83223 |
| DUSP6 | dual specificity phosphatase 6 | 2.76994 |
| COG4 | component of oligomeric golgi complex 4 | 2.76071 |
| RGS2 | regulator of G-protein signaling 2 | 2.69035 |
| ELP3 | elongator acetyltransferase complex subunit 3 | 2.67409 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 2.63636 |
| CCNT1 | cyclin T1 | 2.62337 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | 2.60793 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 2.58557 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 2.58392 |
| KDM3A | lysine (K)-specific demethylase 3A | 2.5607 |
| EXOSC5 | exosome component 5 | 2.55878 |
| EIF2B3 | eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa | 2.55376 |
| TCFL5 | transcription factor-like 5 (basic helix-loop-helix) | 2.53756 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 2.52701 |
| NECAP1 | NECAP endocytosis associated 1 | 2.51636 |
| AMDHD2 | amidohydrolase domain containing 2 | 2.50964 |
| IER3 | immediate early response 3 | 2.50119 |
| XPO4 | exportin 4 | 2.49771 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 2.49532 |
| FICD | FIC domain containing | 2.49087 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | 2.44885 |
| FEM1C | fem-1 homolog c (C. elegans) | 2.43134 |
| HINFP | histone H4 transcription factor | 2.421 |
| ZBTB18 | zinc finger and BTB domain containing 18 | 2.41321 |
| MAP7 | microtubule-associated protein 7 | 2.36227 |
| CYTH2 | cytohesin 2 | 2.35798 |
| GRAMD2B | GRAM domain containing 2B | 2.34483 |
| NCK1 | NCK adaptor protein 1 | 2.33515 |
| TXNL4B | thioredoxin-like 4B | 2.32853 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 2.31137 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 2.31068 |
| WFS1 | Wolfram syndrome 1 (wolframin) | 2.28348 |
| USP15 | ubiquitin specific peptidase 15 | 2.28267 |
| H2AC7 | H2A clustered histone 7 | 2.26828 |
| IL23A | interleukin 23, alpha subunit p19 | 2.26164 |
| EAPP | E2F-associated phosphoprotein | 2.25739 |
| PAF1 | Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) | 2.2512 |
| BTG2 | BTG family, member 2 | 2.19433 |
| TRIM13 | tripartite motif containing 13 | 2.18866 |
| SAA2 | serum amyloid A2 | 2.18682 |
| ATG7 | autophagy related 7 | 2.18682 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 2.18559 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 2.16854 |
| FER | fer (fps/fes related) tyrosine kinase | 2.16097 |
| IER5 | immediate early response 5 | 2.16023 |
| KLF6 | Kruppel-like factor 6 | 2.15347 |
| MCL1 | myeloid cell leukemia 1 | 2.14207 |
| EPN2 | epsin 2 | 2.14069 |
| MAST2 | microtubule associated serine/threonine kinase 2 | 2.14017 |
| CCDC59 | coiled-coil domain containing 59 | 2.13888 |
| TRIB3 | tribbles pseudokinase 3 | 2.10528 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 2.09926 |
| GTF2E2 | general transcription factor IIE, polypeptide 2, beta 34kDa | 2.0983 |
| JMJD6 | jumonji domain containing 6 | 2.07535 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 | 2.07217 |
| PSTPIP2 | proline-serine-threonine phosphatase interacting protein 2 | 2.07095 |
| TTC12 | tetratricopeptide repeat domain 12 | 2.07085 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 2.05119 |
| DCTN4 | dynactin 4 (p62) | 2.03618 |
| AKIP1 | A kinase (PRKA) interacting protein 1 | 2.03464 |
| ZC3H12A | zinc finger CCCH-type containing 12A | 2.03295 |
| FARS2 | phenylalanyl-tRNA synthetase 2, mitochondrial | 2.032 |
| CHMP6 | charged multivesicular body protein 6 | 2.03151 |
| IKZF5 | IKAROS family zinc finger 5 (Pegasus) | 2.0304 |
| RPAP3 | RNA polymerase II associated protein 3 | 2.03 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 2.02551 |
| NAPG | N-ethylmaleimide-sensitive factor attachment protein, gamma | 2.00688 |
| YY1AP1 | YY1 associated protein 1 | 2.00662 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PCNA | proliferating cell nuclear antigen | -7.38826 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -6.80386 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -6.23288 |
| BLCAP | bladder cancer associated protein | -5.60419 |
| GNAS | GNAS complex locus | -5.4212 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | -5.35836 |
| PGAM4 | phosphoglycerate mutase family member 4 | -5.3298 |
| FASTKD5 | FAST kinase domains 5 | -4.92496 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -4.83586 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -4.77731 |
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | -4.76147 |
| GET1 | guided entry of tail-anchored proteins factor 1 | -4.68209 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -4.5039 |
| PARP1 | poly (ADP-ribose) polymerase 1 | -4.42093 |
| VAT1 | vesicle amine transport 1 | -4.19542 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -4.02566 |
| SLC35F2 | solute carrier family 35, member F2 | -3.94027 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.77035 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -3.64704 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -3.54892 |
| MAT2A | methionine adenosyltransferase II, alpha | -3.23413 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.19141 |
| LDHD | lactate dehydrogenase D | -3.18891 |
| VDAC1 | voltage-dependent anion channel 1 | -3.14613 |
| ELAC2 | elaC ribonuclease Z 2 | -3.12867 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | -3.12093 |
| CRYZ | crystallin, zeta (quinone reductase) | -3.03914 |
| POLR1A | polymerase (RNA) I polypeptide A, 194kDa | -3.02447 |
| SCCPDH | saccharopine dehydrogenase (putative) | -3.01859 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -3.00207 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -2.93462 |
| PLOD3 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 | -2.8531 |
| LOC124907782 | dual specificity protein phosphatase 22 | -2.81513 |
| UGDH | UDP-glucose 6-dehydrogenase | -2.80043 |
| DERA | deoxyribose-phosphate aldolase (putative) | -2.78507 |
| GOLGA8A | golgin A8 family, member A | -2.76076 |
| PIP4K2B | phosphatidylinositol-5-phosphate 4-kinase, type II, beta | -2.72916 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -2.69402 |
| TLCD3A | TLC domain containing 3A | -2.68449 |
| CCNB2 | cyclin B2 | -2.67868 |
| HMG20B | high mobility group 20B | -2.65562 |
| IGF2R | insulin-like growth factor 2 receptor | -2.63938 |
| TUBB6 | tubulin, beta 6 class V | -2.6312 |
| LGMN | legumain | -2.59618 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -2.57835 |
| CDC20 | cell division cycle 20 | -2.54137 |
| TUFM | Tu translation elongation factor, mitochondrial | -2.52899 |
| MAPK13 | mitogen-activated protein kinase 13 | -2.50337 |
| TMEM230 | transmembrane protein 230 | -2.49535 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -2.49337 |
| ZNF514 | zinc finger protein 514 | -2.49118 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -2.46467 |
| TSPAN3 | tetraspanin 3 | -2.46168 |
| CCDC92 | coiled-coil domain containing 92 | -2.45838 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | -2.41922 |
| STARD7 | StAR-related lipid transfer (START) domain containing 7 | -2.41496 |
| HMGN1 | high mobility group nucleosome binding domain 1 | -2.39973 |
| CSK | c-src tyrosine kinase | -2.39344 |
| NINL | ninein-like | -2.359 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -2.34222 |
| AHCY | adenosylhomocysteinase | -2.33463 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -2.32369 |
| DAG1 | dystroglycan 1 (dystrophin-associated glycoprotein 1) | -2.31719 |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) | -2.28232 |
| RNASE4 | ribonuclease, RNase A family, 4 | -2.27724 |
| THAP11 | THAP domain containing 11 | -2.26777 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | -2.26314 |
| VPS35 | vacuolar protein sorting 35 homolog (S. cerevisiae) | -2.24271 |
| RAB5IF | RAB5 interacting factor | -2.22522 |
| TXNDC9 | thioredoxin domain containing 9 | -2.21907 |
| TFDP1 | transcription factor Dp-1 | -2.21235 |
| CHEK1 | checkpoint kinase 1 | -2.20888 |
| GTF2A2 | general transcription factor IIA, 2, 12kDa | -2.20328 |
| TMEM109 | transmembrane protein 109 | -2.20146 |
| CDADC1 | cytidine and dCMP deaminase domain containing 1 | -2.19848 |
| PGM1 | phosphoglucomutase 1 | -2.19645 |
| ITGB5 | integrin, beta 5 | -2.19211 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -2.1887 |
| HMOX1 | heme oxygenase 1 | -2.17382 |
| RPIA | ribose 5-phosphate isomerase A | -2.17144 |
| GAA | glucosidase, alpha; acid | -2.16698 |
| DNAJC13 | DnaJ (Hsp40) homolog, subfamily C, member 13 | -2.16244 |
| PSME2 | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | -2.15384 |
| ATRN | attractin | -2.13275 |
| CDC7 | cell division cycle 7 | -2.11787 |
| TM9SF2 | transmembrane 9 superfamily member 2 | -2.11353 |
| SLC16A4 | solute carrier family 16, member 4 | -2.11107 |
| ARHGAP19 | Rho GTPase activating protein 19 | -2.10488 |
| TYRP1 | tyrosinase-related protein 1 | -2.096 |
| SLC35A5 | solute carrier family 35, member A5 | -2.09464 |
| PDE6D | phosphodiesterase 6D, cGMP-specific, rod, delta | -2.075 |
| NENF | neudesin neurotrophic factor | -2.06747 |
| SNX11 | sorting nexin 11 | -2.06537 |
| ZDHHC24 | zinc finger, DHHC-type containing 24 | -2.05831 |
| TCEAL4 | transcription elongation factor A (SII)-like 4 | -2.05723 |
| LBR | lamin B receptor | -2.05582 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -2.05107 |
| WDR11 | WD repeat domain 11 | -2.038 |
| PPP1CA | protein phosphatase 1, catalytic subunit, alpha isozyme | -2.03685 |
| LOC102723713 | TP53-target gene 3 protein | -2.03024 |
| PLA2G3 | phospholipase A2, group III | -2.02889 |
| CDC25B | cell division cycle 25B | -2.02566 |
| KCNJ8 | potassium channel, inwardly rectifying subfamily J, member 8 | -2.02282 |
| NLRP2B | NLR family pyrin domain containing 2B | -2.01993 |
| NAGPA | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase | -2.01826 |
| CBR4 | carbonyl reductase 4 | -2.01663 |
| ANXA7 | annexin A7 | -2.01399 |
| COX5A | cytochrome c oxidase subunit Va | -2.01336 |
| AGBL5 | ATP/GTP binding protein-like 5 | -2.00842 |
| EBNA1BP2 | EBNA1 binding protein 2 | -2.00823 |
| STARD3 | StAR-related lipid transfer (START) domain containing 3 | -2.0054 |
