CRCGN014_HEPG2_3H:F23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description monochloroacetic acid 38.8 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

33 genes differentially expressed following the CRCGN014_HEPG2_3H:F23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 4.12251
CGRRF1 cell growth regulator with ring finger domain 1 4.07478
ABHD4 abhydrolase domain containing 4 3.99139
UBQLN2 ubiquilin 2 3.75101
MAP7 microtubule-associated protein 7 3.70611
AMDHD2 amidohydrolase domain containing 2 3.60556
CHN1 chimerin 1 3.32725
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.2835
GPATCH8 G patch domain containing 8 3.04049
SKIC8 SKI8 subunit of superkiller complex 3.03968
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.61084
MBNL1 muscleblind-like splicing regulator 1 2.27048
SFTPB surfactant protein B 2.24038
CD40 CD40 molecule, TNF receptor superfamily member 5 2.17919
UFM1 ubiquitin-fold modifier 1 2.14891
SSBP2 single-stranded DNA binding protein 2 2.12013
USP6NL USP6 N-terminal like 2.05563

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -6.22977
HACD3 3-hydroxyacyl-CoA dehydratase 3 -5.68835
ZNF586 zinc finger protein 586 -5.37592
LDHD lactate dehydrogenase D -3.82871
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.56594
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.15897
ARID5B AT rich interactive domain 5B (MRF1-like) -2.89457
CCNB2 cyclin B2 -2.80521
UBE3C ubiquitin protein ligase E3C -2.71881
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.54841
GDF15 growth differentiation factor 15 -2.41
SLC35F2 solute carrier family 35, member F2 -2.20567
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.16069
FBXL12 F-box and leucine-rich repeat protein 12 -2.13579
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.09305
PRPF4 pre-mRNA processing factor 4 -2.07036