CRCGN014_HEPG2_3H:F24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description theophylline 40.4 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN014_HEPG2_3H:F24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.68074
STIMATE STIM activating enhancer 5.09737
MAP7 microtubule-associated protein 7 4.97112
STAP2 signal transducing adaptor family member 2 4.13237
ADRB2 adrenoceptor beta 2, surface 4.01176
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.87714
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.61274
CIAO3 cytosolic iron-sulfur assembly component 3 3.52916
SYNGAP1 synaptic Ras GTPase activating protein 1 3.43634
LPAR2 lysophosphatidic acid receptor 2 3.29208
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.28311
EPHB2 EPH receptor B2 3.13194
SAA2 serum amyloid A2 2.83816
CBR3 carbonyl reductase 3 2.48982
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.33907
ABHD6 abhydrolase domain containing 6 2.30902
PCDHB11 protocadherin beta 11 2.23837
TIAM1 T-cell lymphoma invasion and metastasis 1 2.04633

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.25539
ZNF586 zinc finger protein 586 -5.58668
GNAS GNAS complex locus -5.42663
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.10569
BPHL biphenyl hydrolase-like (serine hydrolase) -3.97411
MRPS2 mitochondrial ribosomal protein S2 -3.76748
FGFR4 fibroblast growth factor receptor 4 -3.64026
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.58451
CCNB2 cyclin B2 -3.41932
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.23176
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.17103
TLR4 toll-like receptor 4 -3.13106
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.94508
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.88706
DERA deoxyribose-phosphate aldolase (putative) -2.86537
CSK c-src tyrosine kinase -2.72865
PLK1 polo-like kinase 1 -2.61943
NGRN neugrin, neurite outgrowth associated -2.60998
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.5623
NVL nuclear VCP-like -2.49294
GPR50 G protein-coupled receptor 50 -2.36336
GPR19 G protein-coupled receptor 19 -2.2845
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) -2.22128
ACTR8 ARP8 actin-related protein 8 homolog (yeast) -2.209
TRIM49D2 tripartite motif containing 49D2 -2.13573
SMIM41 small integral membrane protein 41 -2.08603
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 -2.06529
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa -2.06336
NEUROD4 neuronal differentiation 4 -2.01931
MYEF2 myelin expression factor 2 -2.01322