CRCGN014_HEPG2_3H:G02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pirinixic-acid 40.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

98 genes differentially expressed following the CRCGN014_HEPG2_3H:G02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 8.92386
BACE2 beta-site APP-cleaving enzyme 2 8.77653
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 8.74665
MYLK myosin light chain kinase 8.40433
MAP7 microtubule-associated protein 7 7.49371
ADRB2 adrenoceptor beta 2, surface 6.55962
ANO1 anoctamin 1, calcium activated chloride channel 5.66784
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.66217
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 5.38587
CBR3 carbonyl reductase 3 5.1233
C2CD2 C2 calcium-dependent domain containing 2 5.04093
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.93322
LCN2 lipocalin 2 4.78396
MNAT1 MNAT CDK-activating kinase assembly factor 1 4.35348
PPARG peroxisome proliferator-activated receptor gamma 4.29571
MELK maternal embryonic leucine zipper kinase 4.03872
GPER1 G protein-coupled estrogen receptor 1 3.99223
RPL39L ribosomal protein L39-like 3.94049
TBC1D10C TBC1 domain family, member 10C 3.5653
RPP38 ribonuclease P/MRP 38kDa subunit 3.33089
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.32716
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.30317
STX1A syntaxin 1A (brain) 3.11211
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.92531
CRTAP cartilage associated protein 2.86293
DENND2D DENN/MADD domain containing 2D 2.84559
BZW2 basic leucine zipper and W2 domains 2 2.81952
NOSIP nitric oxide synthase interacting protein 2.78661
JADE2 jade family PHD finger 2 2.75134
CHN1 chimerin 1 2.71424
SCCPDH saccharopine dehydrogenase (putative) 2.70932
CXCR4 chemokine (C-X-C motif) receptor 4 2.63051
TAC4 tachykinin 4 (hemokinin) 2.54037
SLC38A6 solute carrier family 38, member 6 2.50502
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.49685
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.48637
MPZL1 myelin protein zero-like 1 2.47676
TRAM2 translocation associated membrane protein 2 2.47662
PARP1 poly (ADP-ribose) polymerase 1 2.47618
EVL Enah/Vasp-like 2.36837
CRISP3 cysteine-rich secretory protein 3 2.33086
SIDT1 SID1 transmembrane family, member 1 2.30615
TIMP2 TIMP metallopeptidase inhibitor 2 2.22071
SCUBE2 signal peptide, CUB domain, EGF-like 2 2.21699
PUS1 pseudouridylate synthase 1 2.19251
RRAGC Ras-related GTP binding C 2.17965
MITF microphthalmia-associated transcription factor 2.17159
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.14651
PTER phosphotriesterase related 2.13021
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.12609
SLC44A4 solute carrier family 44, member 4 2.121
KIFBP kinesin family binding protein 2.11056
LDLRAP1 low density lipoprotein receptor adaptor protein 1 2.10167
MANBA mannosidase, beta A, lysosomal 2.09478
RAB4A RAB4A, member RAS oncogene family 2.08413
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.08156
HMGA2 high mobility group AT-hook 2 2.07022
MLPH melanophilin 2.03404
HLA-DRA major histocompatibility complex, class II, DR alpha 2.01857
TSPAN1 tetraspanin 1 2.01036
TRAK2 trafficking protein, kinesin binding 2 2.00136

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.88203
CCNB2 cyclin B2 -5.035
LDHD lactate dehydrogenase D -4.89078
TLR4 toll-like receptor 4 -4.06458
HAT1 histone acetyltransferase 1 -4.05826
MAPK13 mitogen-activated protein kinase 13 -3.60571
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -3.18992
SNX11 sorting nexin 11 -3.18848
GNAS GNAS complex locus -3.09099
LOC124907782 dual specificity protein phosphatase 22 -2.89017
TXNDC9 thioredoxin domain containing 9 -2.86294
REEP5 receptor accessory protein 5 -2.85322
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.59223
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -2.46374
MCOLN1 mucolipin 1 -2.40871
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.39646
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 -2.38772
GPATCH2L G patch domain containing 2-like -2.38468
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.36813
PLAC1 placenta-specific 1 -2.3446
DUSP14 dual specificity phosphatase 14 -2.33039
PRAF2 PRA1 domain family, member 2 -2.31442
PRPF4 pre-mRNA processing factor 4 -2.29977
OCEL1 occludin/ELL domain containing 1 -2.26295
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.22045
GTF2B general transcription factor IIB -2.21118
NKRF NFKB repressing factor -2.20991
DOK2 docking protein 2, 56kDa -2.19483
RNF167 ring finger protein 167 -2.19174
IGFBP3 insulin-like growth factor binding protein 3 -2.17763
INKA2 inka box actin regulator 2 -2.10331
PMM2 phosphomannomutase 2 -2.08435
INHBE inhibin, beta E -2.06377
RPL39 ribosomal protein L39 -2.05558
ASS1 argininosuccinate synthase 1 -2.04781
NAGA N-acetylgalactosaminidase, alpha- -2.04241
KIAA0232 KIAA0232 -2.00428