CRCGN014_HEPG2_3H:G03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description p-rosaniline.hcl 40.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

96 genes differentially expressed following the CRCGN014_HEPG2_3H:G03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HSPA1A heat shock 70kDa protein 1A 10.0
DDIT4 DNA-damage-inducible transcript 4 9.82978
EGR1 early growth response 1 7.13084
KIFBP kinesin family binding protein 6.01167
BAG3 BCL2-associated athanogene 3 5.95769
JUN jun proto-oncogene 5.06813
CNPY3 canopy FGF signaling regulator 3 4.5477
HSPA1B heat shock 70kDa protein 1B 4.09227
IER3 immediate early response 3 4.01487
CXCL2 chemokine (C-X-C motif) ligand 2 3.89337
DIPK1A divergent protein kinase domain 1A 3.88837
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 3.67264
PPARG peroxisome proliferator-activated receptor gamma 3.65829
FOSL1 FOS-like antigen 1 3.6413
TBPL1 TBP-like 1 3.63162
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 3.61338
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.4755
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 3.3639
ZFP36 ZFP36 ring finger protein 3.35494
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.28537
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.27295
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.24482
CCDC85B coiled-coil domain containing 85B 3.23225
HMOX1 heme oxygenase 1 3.09395
CARMIL1 capping protein regulator and myosin 1 linker 1 3.06579
TRIB3 tribbles pseudokinase 3 3.04526
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.02996
LOC102724023 ES1 protein homolog, mitochondrial 2.99555
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.94526
RRAGA Ras-related GTP binding A 2.91976
PMM2 phosphomannomutase 2 2.89473
ADRB2 adrenoceptor beta 2, surface 2.85324
WASHC4 WASH complex subunit 4 2.82368
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.66034
GPATCH8 G patch domain containing 8 2.64146
GADD45B growth arrest and DNA-damage-inducible, beta 2.58979
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.53932
AXIN1 axin 1 2.46882
TBP TATA box binding protein 2.46211
HYOU1 hypoxia up-regulated 1 2.43809
GSTZ1 glutathione S-transferase zeta 1 2.41467
PEX11A peroxisomal biogenesis factor 11 alpha 2.39021
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.36501
MAP7 microtubule-associated protein 7 2.36325
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.33264
JMJD6 jumonji domain containing 6 2.3004
HSPA6 heat shock 70kDa protein 6 (HSP70B') 2.27876
NPDC1 neural proliferation, differentiation and control, 1 2.25264
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4 2.24786
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.16354
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.13252
RFC2 replication factor C (activator 1) 2, 40kDa 2.0389

decreased expression

Symbol Name Standardized Value
COG7 component of oligomeric golgi complex 7 -6.88307
PCCB propionyl CoA carboxylase, beta polypeptide -6.60968
TARBP1 TAR (HIV-1) RNA binding protein 1 -6.3991
ZNF586 zinc finger protein 586 -5.87665
CD58 CD58 molecule -5.62481
SLC35F2 solute carrier family 35, member F2 -5.23494
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.31514
TRAP1 TNF receptor-associated protein 1 -3.7287
CCNB1 cyclin B1 -3.53881
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -3.48823
COG2 component of oligomeric golgi complex 2 -3.34462
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.27173
LDHD lactate dehydrogenase D -3.26815
CCNB2 cyclin B2 -3.10452
GNAS GNAS complex locus -2.97377
FGFR4 fibroblast growth factor receptor 4 -2.93649
TLCD3A TLC domain containing 3A -2.87494
TLR4 toll-like receptor 4 -2.81554
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.7461
LOC124907782 dual specificity protein phosphatase 22 -2.73699
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.69782
ICAM3 intercellular adhesion molecule 3 -2.65039
EIF5 eukaryotic translation initiation factor 5 -2.55147
CDC25B cell division cycle 25B -2.50532
PEG10 paternally expressed 10 -2.50157
BLCAP bladder cancer associated protein -2.47695
HEATR1 HEAT repeat containing 1 -2.45171
SKIC2 SKI2 subunit of superkiller complex -2.44628
TMEM164 transmembrane protein 164 -2.38368
MAT2A methionine adenosyltransferase II, alpha -2.33433
FAN1 FANCD2/FANCI-associated nuclease 1 -2.2642
TERT telomerase reverse transcriptase -2.24445
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.23378
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.21317
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.20524
AKAP8 A kinase (PRKA) anchor protein 8 -2.19314
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.18591
ZDHHC6 zinc finger, DHHC-type containing 6 -2.15822
GCDH glutaryl-CoA dehydrogenase -2.12756
PIGN phosphatidylinositol glycan anchor biosynthesis, class N -2.07978
WDR7 WD repeat domain 7 -2.07193
TBC1D10C TBC1 domain family, member 10C -2.05343
SCCPDH saccharopine dehydrogenase (putative) -2.04963
COQ9 coenzyme Q9 -2.00946