CRCGN014_HEPG2_3H:G06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description fd & c blue no. 2 40.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN014_HEPG2_3H:G06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KIF14 kinesin family member 14 4.41662
GPER1 G protein-coupled estrogen receptor 1 4.39528
MYLK myosin light chain kinase 3.89773
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.66547
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.46618
PEX11A peroxisomal biogenesis factor 11 alpha 3.2079
C2CD2 C2 calcium-dependent domain containing 2 3.02745
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.88565
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.7057
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.54925
AMDHD2 amidohydrolase domain containing 2 2.53834
CCNF cyclin F 2.338
GPATCH8 G patch domain containing 8 2.28935
CARMIL1 capping protein regulator and myosin 1 linker 1 2.26973
RRAGA Ras-related GTP binding A 2.21936
KIF20A kinesin family member 20A 2.15318
MCUR1 mitochondrial calcium uniporter regulator 1 2.01621

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -6.9722
OXA1L oxidase (cytochrome c) assembly 1-like -4.2874
SNX11 sorting nexin 11 -3.82344
EIF5 eukaryotic translation initiation factor 5 -3.69661
HAT1 histone acetyltransferase 1 -3.53906
BLCAP bladder cancer associated protein -3.52086
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.51699
TLCD3A TLC domain containing 3A -3.18984
LDHD lactate dehydrogenase D -3.18038
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.04035
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.98691
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.86374
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.74924
ZNF586 zinc finger protein 586 -2.71363
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.70439
CSK c-src tyrosine kinase -2.57302
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.42958
RFC2 replication factor C (activator 1) 2, 40kDa -2.42665
HMOX1 heme oxygenase 1 -2.39506
CCNB1 cyclin B1 -2.21046
NRIP1 nuclear receptor interacting protein 1 -2.02463