CRCGN014_HEPG2_3H:G08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description doxylamine 40.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

193 genes differentially expressed following the CRCGN014_HEPG2_3H:G08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 8.48814
PRKCD protein kinase C, delta 5.78341
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.62887
CIAO3 cytosolic iron-sulfur assembly component 3 5.1104
LCN2 lipocalin 2 4.95785
CHN1 chimerin 1 4.53166
CSK c-src tyrosine kinase 4.47214
PHKA1 phosphorylase kinase, alpha 1 (muscle) 4.22374
NOSIP nitric oxide synthase interacting protein 4.21403
ADRB2 adrenoceptor beta 2, surface 4.18147
SRC SRC proto-oncogene, non-receptor tyrosine kinase 4.15534
PEX11A peroxisomal biogenesis factor 11 alpha 4.14712
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 4.06462
CCL2 chemokine (C-C motif) ligand 2 4.03586
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.03558
SYNE2 spectrin repeat containing, nuclear envelope 2 3.70645
LSR lipolysis stimulated lipoprotein receptor 3.69134
PPARG peroxisome proliferator-activated receptor gamma 3.668
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.61734
PRR15L proline rich 15-like 3.60705
MAMLD1 mastermind-like domain containing 1 3.53901
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 3.48171
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.45393
CYCS cytochrome c, somatic 3.42449
PYGB phosphorylase, glycogen; brain 3.17564
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 3.13665
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 3.12826
NT5DC2 5'-nucleotidase domain containing 2 3.12741
DIPK1A divergent protein kinase domain 1A 3.03496
FZD7 frizzled class receptor 7 3.00918
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.98801
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.96343
PRR16 proline rich 16 2.76431
SKA1 spindle and kinetochore associated complex subunit 1 2.74639
GATA2 GATA binding protein 2 2.69369
SFTPB surfactant protein B 2.67358
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) 2.62643
SATB1 SATB homeobox 1 2.6124
SSBP2 single-stranded DNA binding protein 2 2.59991
FMNL3 formin-like 3 2.59054
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 2.54814
TIAM1 T-cell lymphoma invasion and metastasis 1 2.54065
FGFR2 fibroblast growth factor receptor 2 2.53316
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 2.51887
BACE2 beta-site APP-cleaving enzyme 2 2.51697
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 2.497
TBX2 T-box 2 2.48589
NLRP2B NLR family pyrin domain containing 2B 2.47803
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.45869
RFC3 replication factor C (activator 1) 3, 38kDa 2.4574
HDAC5 histone deacetylase 5 2.45316
SDHAF3 succinate dehydrogenase complex assembly factor 3 2.44912
BAD BCL2-associated agonist of cell death 2.4485
SYNGAP1 synaptic Ras GTPase activating protein 1 2.41786
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.40483
PFN2 profilin 2 2.38163
VEGFC vascular endothelial growth factor C 2.37582
GC group-specific component (vitamin D binding protein) 2.37299
DLL3 delta-like 3 (Drosophila) 2.34051
PHOX2A paired-like homeobox 2a 2.33116
SSX1 synovial sarcoma, X breakpoint 1 2.32717
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.32277
FAM193B family with sequence similarity 193, member B 2.31873
WDR41 WD repeat domain 41 2.31033
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.30916
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 2.29821
PTH2R parathyroid hormone 2 receptor 2.28475
SERTAD2 SERTA domain containing 2 2.28334
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 2.27686
ZDHHC6 zinc finger, DHHC-type containing 6 2.27524
CASC3 cancer susceptibility candidate 3 2.26613
VGLL3 vestigial-like family member 3 2.25309
POU4F1 POU class 4 homeobox 1 2.25242
PGAM4 phosphoglycerate mutase family member 4 2.25197
CRYM crystallin, mu 2.23927
TAS2R13 taste receptor, type 2, member 13 2.23278
CD226 CD226 molecule 2.23048
MRPS2 mitochondrial ribosomal protein S2 2.22689
GADD45G growth arrest and DNA-damage-inducible, gamma 2.22447
TMEM109 transmembrane protein 109 2.22007
MSRA methionine sulfoxide reductase A 2.21826
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 2.20695
GSAP gamma-secretase activating protein 2.1937
EGF epidermal growth factor 2.19242
NBAS neuroblastoma amplified sequence 2.18365
ZNF571 zinc finger protein 571 2.17267
RNF41 ring finger protein 41, E3 ubiquitin protein ligase 2.15657
PHEX phosphate regulating endopeptidase homolog, X-linked 2.15233
CA3 carbonic anhydrase III 2.1517
RPGRIP1L RPGRIP1-like 2.14971
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.13943
RHCG Rh family, C glycoprotein 2.13624
MYO18A myosin XVIIIA 2.13182
SLC75A1 solute carrier family 75 member 1 2.12104
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 2.11943
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 2.11142
CD151 CD151 molecule (Raph blood group) 2.10872
EMX1 empty spiracles homeobox 1 2.10779
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 2.10637
GSTA4 glutathione S-transferase alpha 4 2.10018
CBR1 carbonyl reductase 1 2.0978
POLR3B polymerase (RNA) III (DNA directed) polypeptide B 2.09441
TRAPPC3 trafficking protein particle complex 3 2.09183
TNNC2 troponin C type 2 (fast) 2.08633
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.08613
SAGE1 sarcoma antigen 1 2.08536
THADA thyroid adenoma associated 2.07978
TBC1D17 TBC1 domain family, member 17 2.07611
METTL8 methyltransferase like 8 2.07071
CNGA1 cyclic nucleotide gated channel alpha 1 2.06488
ZNF208 zinc finger protein 208 2.05847
PPP1R3C protein phosphatase 1, regulatory subunit 3C 2.05667
ADAT1 adenosine deaminase, tRNA-specific 1 2.05292
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 2.05216
RSU1 Ras suppressor protein 1 2.05197
TSPAN6 tetraspanin 6 2.05172
SEC24C SEC24 family member C 2.04957
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.04411
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 2.04334
OLAH oleoyl-ACP hydrolase 2.03362
RAB21 RAB21, member RAS oncogene family 2.02611
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 2.02281
ZFY zinc finger protein, Y-linked 2.01824
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 2.01199
SHB Src homology 2 domain containing adaptor protein B 2.00921

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -9.05739
CASP7 caspase 7, apoptosis-related cysteine peptidase -8.56553
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -8.06203
FAIM Fas apoptotic inhibitory molecule -6.17482
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.82653
CCNB2 cyclin B2 -4.74588
MAPK13 mitogen-activated protein kinase 13 -4.52438
C2CD5 C2 calcium-dependent domain containing 5 -4.49285
LDHD lactate dehydrogenase D -4.15012
CCNH cyclin H -4.04727
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.78999
CDC20 cell division cycle 20 -3.74836
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -3.60092
FBXO7 F-box protein 7 -3.46308
MOK MOK protein kinase -3.37515
FBXL12 F-box and leucine-rich repeat protein 12 -3.33018
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.22251
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -3.19992
CRYZ crystallin, zeta (quinone reductase) -3.14587
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -3.12917
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.94634
NGRN neugrin, neurite outgrowth associated -2.93955
CAB39 calcium binding protein 39 -2.92971
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.89718
ENOPH1 enolase-phosphatase 1 -2.85668
SDCBP syndecan binding protein (syntenin) -2.70086
HNRNPK heterogeneous nuclear ribonucleoprotein K -2.67627
SHARPIN SHANK-associated RH domain interactor -2.66269
GNAS GNAS complex locus -2.61643
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 -2.59692
BPHL biphenyl hydrolase-like (serine hydrolase) -2.59127
MOAP1 modulator of apoptosis 1 -2.55635
SNRPE small nuclear ribonucleoprotein polypeptide E -2.5222
SLIRP SRA stem-loop interacting RNA binding protein -2.4802
HMG20B high mobility group 20B -2.41391
RFC2 replication factor C (activator 1) 2, 40kDa -2.40994
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.39837
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 -2.39666
MRPL3 mitochondrial ribosomal protein L3 -2.3887
NUP93 nucleoporin 93kDa -2.34253
IFRD2 interferon-related developmental regulator 2 -2.33483
TPBG trophoblast glycoprotein -2.31641
HAT1 histone acetyltransferase 1 -2.2743
HSPA8 heat shock 70kDa protein 8 -2.2612
EBNA1BP2 EBNA1 binding protein 2 -2.25373
MTA1 metastasis associated 1 -2.24312
PCDH12 protocadherin 12 -2.16929
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.14642
FOS FBJ murine osteosarcoma viral oncogene homolog -2.14493
DDB2 damage-specific DNA binding protein 2, 48kDa -2.13632
SOAT2 sterol O-acyltransferase 2 -2.11277
TOB1 transducer of ERBB2, 1 -2.11183
PABPC3 poly(A) binding protein, cytoplasmic 3 -2.10981
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.08749
TDP2 tyrosyl-DNA phosphodiesterase 2 -2.08309
BMP7 bone morphogenetic protein 7 -2.07701
GRK5 G protein-coupled receptor kinase 5 -2.07695
FAM13B family with sequence similarity 13, member B -2.04745
FGF18 fibroblast growth factor 18 -2.04335
TASL TLR adaptor interacting with endolysosomal SLC15A4 -2.04078
GIMAP6 GTPase, IMAP family member 6 -2.04001
OXA1L oxidase (cytochrome c) assembly 1-like -2.03978
TGIF2 TGFB-induced factor homeobox 2 -2.02967
DGAT1 diacylglycerol O-acyltransferase 1 -2.02269
TCERG1 transcription elongation regulator 1 -2.01891
TAC1 tachykinin, precursor 1 -2.01784
ZFR2 zinc finger RNA binding protein 2 -2.01477
EIF5 eukaryotic translation initiation factor 5 -2.00756