CRCGN014_HEPG2_3H:G09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

69 genes differentially expressed following the CRCGN014_HEPG2_3H:G09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 7.90558
TREM1 triggering receptor expressed on myeloid cells 1 4.93635
MYLK myosin light chain kinase 4.49224
ABHD6 abhydrolase domain containing 6 4.35467
PNKP polynucleotide kinase 3'-phosphatase 4.19617
CXCL2 chemokine (C-X-C motif) ligand 2 3.78278
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.69835
MSRA methionine sulfoxide reductase A 3.65675
LCN2 lipocalin 2 3.65545
SYNE2 spectrin repeat containing, nuclear envelope 2 3.63896
DIPK1A divergent protein kinase domain 1A 3.47457
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.30191
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.23839
CIAO3 cytosolic iron-sulfur assembly component 3 3.19888
ANO1 anoctamin 1, calcium activated chloride channel 3.1692
STIMATE STIM activating enhancer 2.94437
ATP11B ATPase, class VI, type 11B 2.93993
BMP4 bone morphogenetic protein 4 2.78134
STXBP2 syntaxin binding protein 2 2.62466
RAB31 RAB31, member RAS oncogene family 2.60813
EPN2 epsin 2 2.5929
NOTCH1 notch 1 2.41762
E2F2 E2F transcription factor 2 2.4104
DEF8 differentially expressed in FDCP 8 homolog (mouse) 2.38313
SORBS3 sorbin and SH3 domain containing 3 2.36633
MICALL1 MICAL-like 1 2.33281
KDM5A lysine (K)-specific demethylase 5A 2.32197
SSBP2 single-stranded DNA binding protein 2 2.31216
IDE insulin-degrading enzyme 2.29931
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.28763
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.26178
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.25909
SAA2 serum amyloid A2 2.24718
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 2.24662
SYNM synemin, intermediate filament protein 2.24624
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 2.19937
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 2.18054
CNPY3 canopy FGF signaling regulator 3 2.17411
CEP57 centrosomal protein 57kDa 2.17224
MAST2 microtubule associated serine/threonine kinase 2 2.14775
VGLL4 vestigial-like family member 4 2.13896
WDTC1 WD and tetratricopeptide repeats 1 2.13094
DNAI1 dynein, axonemal, intermediate chain 1 2.11134
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 2.10245
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.10027
AHNAK2 AHNAK nucleoprotein 2 2.01851

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -7.80138
KDM3A lysine (K)-specific demethylase 3A -4.36937
C2CD5 C2 calcium-dependent domain containing 5 -4.31879
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.85839
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.59143
CDC20 cell division cycle 20 -3.28703
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.2571
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -3.22333
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.16649
ARID5B AT rich interactive domain 5B (MRF1-like) -2.94832
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.91966
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.69079
PGM1 phosphoglucomutase 1 -2.69014
PEG10 paternally expressed 10 -2.63952
FOXJ3 forkhead box J3 -2.38745
YME1L1 YME1-like 1 ATPase -2.30252
NUP85 nucleoporin 85kDa -2.30094
PCNA proliferating cell nuclear antigen -2.29639
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.16492
SPOUT1 SPOUT domain containing methyltransferase 1 -2.13537
CES3 carboxylesterase 3 -2.0853
PLEKHA5 pleckstrin homology domain containing, family A member 5 -2.04991
OXA1L oxidase (cytochrome c) assembly 1-like -2.03979