CRCGN014_HEPG2_3H:G10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

75 genes differentially expressed following the CRCGN014_HEPG2_3H:G10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STAP2 signal transducing adaptor family member 2 5.85136
NOTCH1 notch 1 4.77611
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.57221
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.53329
CSK c-src tyrosine kinase 4.47451
CGRRF1 cell growth regulator with ring finger domain 1 4.05946
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.91972
TESK1 testis-specific kinase 1 3.91481
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 3.60785
KIF20A kinesin family member 20A 3.50722
ABHD6 abhydrolase domain containing 6 3.28133
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 3.22938
CHN1 chimerin 1 3.17777
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.0759
TXNL4B thioredoxin-like 4B 3.00296
GPER1 G protein-coupled estrogen receptor 1 2.6708
GPATCH8 G patch domain containing 8 2.67029
CCDC85B coiled-coil domain containing 85B 2.58681
ARMC6 armadillo repeat containing 6 2.58175
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.55178
CCP110 centriolar coiled coil protein 110kDa 2.5217
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.40573
GARRE1 granule associated Rac and RHOG effector 1 2.35112
TTC13 tetratricopeptide repeat domain 13 2.31917
TCTA T-cell leukemia translocation altered 2.24721
BPHL biphenyl hydrolase-like (serine hydrolase) 2.22617
CKAP2 cytoskeleton associated protein 2 2.21129
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 2.13955
MEST mesoderm specific transcript 2.12079
MTMR12 myotubularin related protein 12 2.09488
BAX BCL2-associated X protein 2.09183
AMN amnion associated transmembrane protein 2.08242
SECTM1 secreted and transmembrane 1 2.06932
DCLRE1B DNA cross-link repair 1B 2.06312
FBXO31 F-box protein 31 2.05595
CREB3L4 cAMP responsive element binding protein 3-like 4 2.02831
DEK DEK proto-oncogene 2.0231
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 2.02243
NECAB2 N-terminal EF-hand calcium binding protein 2 2.0168
AEN apoptosis enhancing nuclease 2.00686
UBE2A ubiquitin-conjugating enzyme E2A 2.00371
SCYL3 SCY1-like 3 (S. cerevisiae) 2.00048

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -9.27173
CCNB2 cyclin B2 -9.25443
ZNF586 zinc finger protein 586 -5.43126
HACD3 3-hydroxyacyl-CoA dehydratase 3 -5.27259
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.65789
CDC20 cell division cycle 20 -4.34466
SNX11 sorting nexin 11 -4.18862
CHMP4B charged multivesicular body protein 4B -3.97643
OXA1L oxidase (cytochrome c) assembly 1-like -3.11844
TM9SF3 transmembrane 9 superfamily member 3 -3.02033
ZMIZ1 zinc finger, MIZ-type containing 1 -2.99487
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.77939
TM9SF2 transmembrane 9 superfamily member 2 -2.72403
CDC25B cell division cycle 25B -2.65947
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.56743
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -2.52079
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.51282
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.46971
EPHX2 epoxide hydrolase 2, cytoplasmic -2.36876
SLC35F2 solute carrier family 35, member F2 -2.31871
EFNB2 ephrin-B2 -2.27689
TTC17 tetratricopeptide repeat domain 17 -2.24183
PECR peroxisomal trans-2-enoyl-CoA reductase -2.22777
ITK IL2-inducible T-cell kinase -2.20078
BTNL8 butyrophilin-like 8 -2.16017
SLAMF1 signaling lymphocytic activation molecule family member 1 -2.14026
PGAP4 post-GPI attachment to proteins GalNAc transferase 4 -2.12488
ZWILCH zwilch kinetochore protein -2.11692
CCL23 chemokine (C-C motif) ligand 23 -2.10339
STX4 syntaxin 4 -2.06465
POLR2M polymerase (RNA) II (DNA directed) polypeptide M -2.05819
TM4SF20 transmembrane 4 L six family member 20 -2.03022
CCDC25 coiled-coil domain containing 25 -2.01071