CRCGN014_HEPG2_3H:G12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description malathion 21.19 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

121 genes differentially expressed following the CRCGN014_HEPG2_3H:G12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 9.28877
CCNF cyclin F 4.76377
PRKCD protein kinase C, delta 4.52584
CIAO3 cytosolic iron-sulfur assembly component 3 4.48526
RPP38 ribonuclease P/MRP 38kDa subunit 4.35698
CARMIL1 capping protein regulator and myosin 1 linker 1 4.27338
CBR3 carbonyl reductase 3 4.22139
UBQLN2 ubiquilin 2 4.19505
STIMATE STIM activating enhancer 4.09112
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.95023
EPN2 epsin 2 3.84137
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.71373
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 3.29172
CHEK2 checkpoint kinase 2 2.92751
GPER1 G protein-coupled estrogen receptor 1 2.8884
EPHA3 EPH receptor A3 2.80066
POU4F1 POU class 4 homeobox 1 2.71559
SPRR3 small proline-rich protein 3 2.69333
AXIN1 axin 1 2.6594
LTBP1 latent transforming growth factor beta binding protein 1 2.65039
TIAM1 T-cell lymphoma invasion and metastasis 1 2.62674
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.60982
SIRT3 sirtuin 3 2.60682
TBXA2R thromboxane A2 receptor 2.59013
SFTPB surfactant protein B 2.57665
NUP133 nucleoporin 133kDa 2.53449
LPAR2 lysophosphatidic acid receptor 2 2.52567
MAT2B methionine adenosyltransferase II, beta 2.48187
IQGAP1 IQ motif containing GTPase activating protein 1 2.47695
HBA1 hemoglobin, alpha 1 2.43167
GID8 GID complex subunit 8 2.42473
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.37414
KRT13 keratin 13, type I 2.37143
UPK1B uroplakin 1B 2.34538
TNIP1 TNFAIP3 interacting protein 1 2.33369
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 2.33151
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.30981
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.27829
TMPRSS11D transmembrane protease, serine 11D 2.23267
FOXC1 forkhead box C1 2.22812
TXNRD1 thioredoxin reductase 1 2.22279
MMP24-AS1-EDEM2 MMP24-AS1-EDEM2 readthrough 2.19273
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.1841
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 2.16606
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 2.16132
STX10 syntaxin 10 2.16081
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.16036
EYA2 EYA transcriptional coactivator and phosphatase 2 2.15165
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 2.13368
LOC112694756 uncharaterized LOC112694756 2.12616
MUC4 mucin 4, cell surface associated 2.11118
EHD3 EH-domain containing 3 2.09954
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 2.08439
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 2.0789
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 2.0752
BCAS1 breast carcinoma amplified sequence 1 2.06763
SDF2 stromal cell-derived factor 2 2.06205
TSC22D4 TSC22 domain family, member 4 2.05927
GPATCH8 G patch domain containing 8 2.05348
PGPEP1 pyroglutamyl-peptidase I 2.04332
VPS9D1 VPS9 domain containing 1 2.04042
SUOX sulfite oxidase 2.03716
CRNN cornulin 2.03556
DNASE1L1 deoxyribonuclease I-like 1 2.02801
ITPKC inositol-trisphosphate 3-kinase C 2.0065
SMAGP small cell adhesion glycoprotein 2.00612

decreased expression

Symbol Name Standardized Value
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -5.48113
ZNF586 zinc finger protein 586 -5.2581
CCNB2 cyclin B2 -4.83724
CCDC86 coiled-coil domain containing 86 -4.79397
LDHD lactate dehydrogenase D -4.57096
DNM1L dynamin 1-like -4.536
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.46469
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.37562
FGFR4 fibroblast growth factor receptor 4 -4.2164
TRIB3 tribbles pseudokinase 3 -4.05615
ZMIZ1 zinc finger, MIZ-type containing 1 -3.51768
RFC2 replication factor C (activator 1) 2, 40kDa -2.92573
ZP2 zona pellucida glycoprotein 2 (sperm receptor) -2.75331
ZW10 zw10 kinetochore protein -2.6839
TLX3 T-cell leukemia homeobox 3 -2.53851
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.5259
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.512
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 -2.5071
SEC61G Sec61 gamma subunit -2.4912
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -2.44958
AK6 adenylate kinase 6 -2.42825
AVL9 AVL9 homolog (S. cerevisiase) -2.42734
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -2.3498
LOC107986346 mitochondrial import receptor subunit TOM7 homolog -2.34801
CSF2 colony stimulating factor 2 (granulocyte-macrophage) -2.32582
CCR6 chemokine (C-C motif) receptor 6 -2.3245
RUNX3 runt-related transcription factor 3 -2.29101
PNLIPRP2 pancreatic lipase-related protein 2 -2.28676
RBM6 RNA binding motif protein 6 -2.28581
CAMK1 calcium/calmodulin-dependent protein kinase I -2.25881
WDR7 WD repeat domain 7 -2.21494
SCGB2A2 secretoglobin, family 2A, member 2 -2.21463
PAGE1 P antigen family, member 1 (prostate associated) -2.1942
NUSAP1 nucleolar and spindle associated protein 1 -2.168
GCG glucagon -2.16422
SCRT1 scratch family zinc finger 1 -2.15628
SNTG2 syntrophin, gamma 2 -2.15415
ENPEP glutamyl aminopeptidase (aminopeptidase A) -2.14776
GGCT gamma-glutamylcyclotransferase -2.14067
TTC23 tetratricopeptide repeat domain 23 -2.12813
CPA1 carboxypeptidase A1 (pancreatic) -2.12085
TRIM44 tripartite motif containing 44 -2.09931
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.09728
CCL15 chemokine (C-C motif) ligand 15 -2.09081
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha -2.08908
IL37 interleukin 37 -2.08493
KRT2 keratin 2, type II -2.08447
GUSB glucuronidase, beta -2.08417
SLC43A3 solute carrier family 43, member 3 -2.07899
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 -2.07102
PCF11 PCF11 cleavage and polyadenylation factor subunit -2.07035
SNX10 sorting nexin 10 -2.06686
MINPP1 multiple inositol-polyphosphate phosphatase 1 -2.03418
WNT3 wingless-type MMTV integration site family, member 3 -2.00562
REG1B regenerating islet-derived 1 beta -2.00485