CRCGN014_HEPG2_3H:G13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description c.i. acid orange 10 40.2 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN014_HEPG2_3H:G13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TIAM1 T-cell lymphoma invasion and metastasis 1 5.29369
STK10 serine/threonine kinase 10 5.14095
MNAT1 MNAT CDK-activating kinase assembly factor 1 5.07487
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 3.97926
CYCS cytochrome c, somatic 3.42281
C2CD2 C2 calcium-dependent domain containing 2 3.3626
NOTCH1 notch 1 3.31498
CDK19 cyclin-dependent kinase 19 2.90573
ZNF589 zinc finger protein 589 2.85084
LSR lipolysis stimulated lipoprotein receptor 2.78637
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.52023
FZD7 frizzled class receptor 7 2.51497
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.47591
MAP7 microtubule-associated protein 7 2.36961
MCUR1 mitochondrial calcium uniporter regulator 1 2.26884
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.22497
CSK c-src tyrosine kinase 2.18995
PRKCH protein kinase C, eta 2.12716
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.10777
CARMIL1 capping protein regulator and myosin 1 linker 1 2.07297
KIF5C kinesin family member 5C 2.06332
ANO3 anoctamin 3 2.04166
KIF20A kinesin family member 20A 2.00165

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.5678
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.66433
ZNF586 zinc finger protein 586 -4.899
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -4.83693
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.82263
CCNB2 cyclin B2 -4.28188
TLCD3A TLC domain containing 3A -3.85301
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -3.23579
OXA1L oxidase (cytochrome c) assembly 1-like -3.16119
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.01628
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.54368
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.5325
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.52762
UGDH UDP-glucose 6-dehydrogenase -2.21125
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.17225
TRIB3 tribbles pseudokinase 3 -2.1493