CRCGN014_HEPG2_3H:G15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (2's,6r,7r,z)-7-hydroxy-3',6,7,14-tetramethyl-2,9-dioxa-14-azaspiro[bicyclo[9.5.1]heptadec[11]ene-4,2'-oxirane]-3,8,17-trione 19.93 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

76 genes differentially expressed following the CRCGN014_HEPG2_3H:G15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 6.5842
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.23009
ABHD6 abhydrolase domain containing 6 5.81222
MAP7 microtubule-associated protein 7 4.78969
TIAM1 T-cell lymphoma invasion and metastasis 1 4.27415
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 4.26087
LCN2 lipocalin 2 4.18111
BACE2 beta-site APP-cleaving enzyme 2 3.81656
DYNLT3 dynein, light chain, Tctex-type 3 3.79347
CXCL2 chemokine (C-X-C motif) ligand 2 3.78978
PNKP polynucleotide kinase 3'-phosphatase 3.6787
UBQLN2 ubiquilin 2 3.52497
ZBTB18 zinc finger and BTB domain containing 18 3.48231
HSPA1A heat shock 70kDa protein 1A 3.43047
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.41763
INTS3 integrator complex subunit 3 3.37092
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.32861
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.32601
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.31893
ARID4B AT rich interactive domain 4B (RBP1-like) 3.26697
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.21948
LPAR2 lysophosphatidic acid receptor 2 3.02967
MELK maternal embryonic leucine zipper kinase 3.01889
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.99705
STIMATE STIM activating enhancer 2.92947
VAV3 vav 3 guanine nucleotide exchange factor 2.92448
E2F2 E2F transcription factor 2 2.71068
MMP3 matrix metallopeptidase 3 2.67114
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.62052
HAT1 histone acetyltransferase 1 2.60136
RPP38 ribonuclease P/MRP 38kDa subunit 2.59514
CEP57 centrosomal protein 57kDa 2.50084
MYLK myosin light chain kinase 2.4724
MMP1 matrix metallopeptidase 1 2.43083
PRR15L proline rich 15-like 2.34165
GATA3 GATA binding protein 3 2.33944
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.28529
CCP110 centriolar coiled coil protein 110kDa 2.16935
NOSIP nitric oxide synthase interacting protein 2.15696
H2BC12 H2B clustered histone 12 2.13005
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.08478
CBR3 carbonyl reductase 3 2.04346
SELE selectin E 2.01262

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -7.26219
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -6.53269
ZNF586 zinc finger protein 586 -5.60549
TLR4 toll-like receptor 4 -5.5452
TLCD3A TLC domain containing 3A -4.55238
EIF5 eukaryotic translation initiation factor 5 -4.11801
LDHD lactate dehydrogenase D -3.68718
CDC20 cell division cycle 20 -3.5095
ISOC1 isochorismatase domain containing 1 -3.48379
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.4069
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.37263
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.32392
ADI1 acireductone dioxygenase 1 -3.23348
OXA1L oxidase (cytochrome c) assembly 1-like -3.18111
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.10278
TXNDC9 thioredoxin domain containing 9 -3.0254
VAT1 vesicle amine transport 1 -2.99016
MRPS2 mitochondrial ribosomal protein S2 -2.8338
THAP11 THAP domain containing 11 -2.71626
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.61769
WASHC4 WASH complex subunit 4 -2.37019
NLGN1 neuroligin 1 -2.24881
ZNF132 zinc finger protein 132 -2.23711
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 -2.21835
WDR41 WD repeat domain 41 -2.19482
FGFR4 fibroblast growth factor receptor 4 -2.18396
GNAS GNAS complex locus -2.094
AURKB aurora kinase B -2.04951
SNX11 sorting nexin 11 -2.02684
TSPAN4 tetraspanin 4 -2.02313
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 -2.01373
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 -2.01369
EPS8L2 EPS8-like 2 -2.00003