CRCGN014_HEPG2_3H:G19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methylethylketoxime 39.6 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN014_HEPG2_3H:G19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.95609
MAP7 microtubule-associated protein 7 4.19582
CXCR4 chemokine (C-X-C motif) receptor 4 3.73666
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.71977
SLC75A1 solute carrier family 75 member 1 3.63477
SYNE2 spectrin repeat containing, nuclear envelope 2 3.50076
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.45583
CBR3 carbonyl reductase 3 3.44829
MYLK myosin light chain kinase 3.31527
LPAR2 lysophosphatidic acid receptor 2 3.01961
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.01481
TERT telomerase reverse transcriptase 2.98823
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.79842
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.62283
GATD3 glutamine amidotransferase class 1 domain containing 3 2.53392
CSK c-src tyrosine kinase 2.49121
EXOSC4 exosome component 4 2.46389
AMDHD2 amidohydrolase domain containing 2 2.43735
TIAM1 T-cell lymphoma invasion and metastasis 1 2.39229
PFKL phosphofructokinase, liver 2.29359
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 2.22633
VGLL4 vestigial-like family member 4 2.05873

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.22314
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.26736
VAT1 vesicle amine transport 1 -4.18385
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.7064
GTPBP8 GTP-binding protein 8 (putative) -3.59568
PCNA proliferating cell nuclear antigen -3.07631
MAPK13 mitogen-activated protein kinase 13 -2.9349
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.8265
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.51368
HAT1 histone acetyltransferase 1 -2.47371
REEP5 receptor accessory protein 5 -2.25148
PRPF4 pre-mRNA processing factor 4 -2.17946
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.14364
PEG10 paternally expressed 10 -2.11402
NLGN4X neuroligin 4, X-linked -2.10073
LINC02762 long intergenic non-protein coding RNA 2762 -2.05737
CDC25B cell division cycle 25B -2.04748