CRCGN014_HEPG2_3H:H01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description vinyl acetate 41.2 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

138 genes differentially expressed following the CRCGN014_HEPG2_3H:H01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 6.48685
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.85579
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.76475
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.71635
CIAO3 cytosolic iron-sulfur assembly component 3 4.65719
C2CD2 C2 calcium-dependent domain containing 2 4.48312
GATA3 GATA binding protein 3 4.25179
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.14264
EPHB2 EPH receptor B2 4.07714
TAC4 tachykinin 4 (hemokinin) 3.82272
SCRN1 secernin 1 3.80336
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.80237
HOXA10 homeobox A10 3.66137
CGRRF1 cell growth regulator with ring finger domain 1 3.4482
MAP7 microtubule-associated protein 7 3.20855
KIFBP kinesin family binding protein 3.13101
DEPDC5 DEP domain containing 5 3.06224
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 2.99706
CHMP6 charged multivesicular body protein 6 2.98746
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.89891
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.83514
CLASRP CLK4-associating serine/arginine rich protein 2.83319
ADRB2 adrenoceptor beta 2, surface 2.81549
RAB4A RAB4A, member RAS oncogene family 2.67818
CRYGA crystallin, gamma A 2.67404
CAV3 caveolin 3 2.65717
STXBP2 syntaxin binding protein 2 2.60183
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.58743
SNAP25 synaptosomal-associated protein, 25kDa 2.56218
HPRT1 hypoxanthine phosphoribosyltransferase 1 2.52965
CRYBA4 crystallin, beta A4 2.46899
RNF32 ring finger protein 32 2.45649
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.42834
GPER1 G protein-coupled estrogen receptor 1 2.4137
NPPA natriuretic peptide A 2.41213
PITX3 paired-like homeodomain 3 2.40545
MAP3K20 mitogen-activated protein kinase kinase kinase 20 2.39619
SNAI1 snail family zinc finger 1 2.38033
MROH7 maestro heat-like repeat family member 7 2.36763
KIF14 kinesin family member 14 2.36113
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.35666
CLCN6 chloride channel, voltage-sensitive 6 2.35358
REM1 RAS (RAD and GEM)-like GTP-binding 1 2.34976
EPHA3 EPH receptor A3 2.34231
GJA3 gap junction protein, alpha 3, 46kDa 2.34097
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 2.33395
LMO7 LIM domain 7 2.33346
CHEK2 checkpoint kinase 2 2.33114
MYBPC3 myosin binding protein C, cardiac 2.32228
MTNR1B melatonin receptor 1B 2.31948
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 2.31823
PRDM5 PR domain containing 5 2.31532
PRAMEF13 PRAME family member 13 2.29941
LGALS14 lectin, galactoside-binding, soluble, 14 2.29007
PRDX1 peroxiredoxin 1 2.28251
GINS2 GINS complex subunit 2 (Psf2 homolog) 2.25953
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.25399
RORC RAR-related orphan receptor C 2.25358
MAGEL2 melanoma antigen family L2 2.25187
LHX3 LIM homeobox 3 2.2446
MYLK myosin light chain kinase 2.23899
PCDHGB5 protocadherin gamma subfamily B, 5 2.23834
RFX4 regulatory factor X, 4 (influences HLA class II expression) 2.2358
LCT lactase 2.2051
NYX nyctalopin 2.20089
MPV17 MpV17 mitochondrial inner membrane protein 2.19989
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 2.19262
OR3A3 olfactory receptor, family 3, subfamily A, member 3 2.19082
NANOS3 nanos homolog 3 (Drosophila) 2.17454
MYBPH myosin binding protein H 2.17245
GRIK3 glutamate receptor, ionotropic, kainate 3 2.16633
PHF13 PHD finger protein 13 2.16193
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha 2.15254
SYMPK symplekin 2.14471
SPTBN5 spectrin, beta, non-erythrocytic 5 2.12469
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.1245
MYOD1 myogenic differentiation 1 2.12429
N4BP3 NEDD4 binding protein 3 2.12086
PPIL6 peptidylprolyl isomerase (cyclophilin)-like 6 2.11054
DCHS2 dachsous cadherin-related 2 2.10863
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 2.10472
SHBG sex hormone-binding globulin 2.09926
HOXB1 homeobox B1 2.09881
MINAR1 membrane integral NOTCH2 associated receptor 1 2.09438
NPY4R2 neuropeptide Y receptor Y4-2 2.09366
ZFHX4 zinc finger homeobox 4 2.09336
AFAP1 actin filament associated protein 1 2.07976
BAAT bile acid CoA:amino acid N-acyltransferase 2.07595
C1QL1 complement component 1, q subcomponent-like 1 2.07283
PMP2 peripheral myelin protein 2 2.06473
KRTAP1-1 keratin associated protein 1-1 2.0601
TULP4 tubby like protein 4 2.05637
BCAS4 breast carcinoma amplified sequence 4 2.04961
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 2.04954
MCPH1 microcephalin 1 2.04487
RBL1 retinoblastoma-like 1 2.04259
SYCP2 synaptonemal complex protein 2 2.04254
LOC107985101 uncharacterized LOC107985101 2.0362
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.03612
KISS1 KiSS-1 metastasis-suppressor 2.03535
TCOF1 Treacher Collins-Franceschetti syndrome 1 2.03408
SFTPB surfactant protein B 2.02889
TDRKH tudor and KH domain containing 2.02607
CCN4 cellular communication network factor 4 2.0096
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 2.00663
DOK3 docking protein 3 2.00555
C8B complement component 8, beta polypeptide 2.00395
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 2.00084

decreased expression

Symbol Name Standardized Value
ITFG1 integrin alpha FG-GAP repeat containing 1 -9.17184
WDR7 WD repeat domain 7 -6.1079
CAB39 calcium binding protein 39 -5.77347
FAIM Fas apoptotic inhibitory molecule -5.09081
TSPAN4 tetraspanin 4 -4.78088
ARID5B AT rich interactive domain 5B (MRF1-like) -4.65229
LDHD lactate dehydrogenase D -4.62256
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.53519
CCNB2 cyclin B2 -4.47581
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.38085
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.15468
NGRN neugrin, neurite outgrowth associated -3.9165
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.91293
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.87846
IPO13 importin 13 -2.69945
GBE1 glucan (1,4-alpha-), branching enzyme 1 -2.57849
FOXJ3 forkhead box J3 -2.40269
FASTKD5 FAST kinase domains 5 -2.25703
FOS FBJ murine osteosarcoma viral oncogene homolog -2.19595
NPTX1 neuronal pentraxin I -2.17766
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 -2.15936
SEC61G Sec61 gamma subunit -2.11132
APIP APAF1 interacting protein -2.10801
GTPBP2 GTP binding protein 2 -2.10695
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon -2.08423
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A -2.06619
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 -2.06116
TXNDC9 thioredoxin domain containing 9 -2.05702
RAI2 retinoic acid induced 2 -2.03718
MAPK14 mitogen-activated protein kinase 14 -2.00893