CRCGN014_HEPG2_3H:H02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o-phenylenediamine.2hcl 40.8 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

64 genes differentially expressed following the CRCGN014_HEPG2_3H:H02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 6.86989
CIAO3 cytosolic iron-sulfur assembly component 3 6.74022
CYCS cytochrome c, somatic 5.45936
MAP7 microtubule-associated protein 7 5.33885
SNAP25 synaptosomal-associated protein, 25kDa 5.31355
HPRT1 hypoxanthine phosphoribosyltransferase 1 4.83157
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 3.7183
INPP1 inositol polyphosphate-1-phosphatase 3.67467
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.6214
ANO1 anoctamin 1, calcium activated chloride channel 3.57655
EDN1 endothelin 1 3.49011
LOC122526780 uncharacterized LOC122526780 3.16024
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.14094
RPP38 ribonuclease P/MRP 38kDa subunit 2.91109
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.8807
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.88053
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.87123
BACE2 beta-site APP-cleaving enzyme 2 2.82514
SMIM40 small integral membrane protein 40 2.69285
CXCR4 chemokine (C-X-C motif) receptor 4 2.63178
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.63072
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.50995
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.49449
DDIT4 DNA-damage-inducible transcript 4 2.31964
UGDH UDP-glucose 6-dehydrogenase 2.28697
ZW10 zw10 kinetochore protein 2.2642
KIF14 kinesin family member 14 2.23475
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.2307
TWF2 twinfilin actin binding protein 2 2.20606
SOCS2 suppressor of cytokine signaling 2 2.2034
KIAA0040 KIAA0040 2.18973
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.1756
MAST2 microtubule associated serine/threonine kinase 2 2.14644
ADSS2 adenylosuccinate synthase 2 2.14307
MBOAT7 membrane bound O-acyltransferase domain containing 7 2.1053
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 2.09145
DYNLL1 dynein, light chain, LC8-type 1 2.08102
MSTO1 misato 1, mitochondrial distribution and morphology regulator 2.02913
TXNRD1 thioredoxin reductase 1 2.01665

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -9.87196
DHRS7 dehydrogenase/reductase (SDR family) member 7 -6.97385
LDHD lactate dehydrogenase D -6.24224
OXA1L oxidase (cytochrome c) assembly 1-like -4.70576
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.94464
SCAND1 SCAN domain containing 1 -3.6029
PCCB propionyl CoA carboxylase, beta polypeptide -3.52891
CLTB clathrin, light chain B -3.39952
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.38418
PCNA proliferating cell nuclear antigen -3.36963
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.02809
ZMIZ1 zinc finger, MIZ-type containing 1 -2.88098
AURKB aurora kinase B -2.85421
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.62444
NRIP1 nuclear receptor interacting protein 1 -2.53751
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.53278
CD7 CD7 molecule -2.41977
FGFR4 fibroblast growth factor receptor 4 -2.26284
BIRC2 baculoviral IAP repeat containing 2 -2.22825
MELK maternal embryonic leucine zipper kinase -2.17524
TBKBP1 TBK1 binding protein 1 -2.17493
NUSAP1 nucleolar and spindle associated protein 1 -2.0829
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha -2.07869
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 -2.04855
TSPAN9 tetraspanin 9 -2.02237