CRCGN014_HEPG2_3H:H03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-amino-2-methylanthraquinone 39.6 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN014_HEPG2_3H:H03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 4.20951
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.05394
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.86035
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.67935
UBQLN2 ubiquilin 2 3.63263
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.57304
CIAO3 cytosolic iron-sulfur assembly component 3 3.38119
CSK c-src tyrosine kinase 3.22872
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.14283
CBR3 carbonyl reductase 3 3.10504
DDIT4 DNA-damage-inducible transcript 4 2.96826
STAP2 signal transducing adaptor family member 2 2.91638
LCN2 lipocalin 2 2.87026
ADGRE5 adhesion G protein-coupled receptor E5 2.8036
MYLK myosin light chain kinase 2.67524
CARMIL1 capping protein regulator and myosin 1 linker 1 2.65239
MAP7 microtubule-associated protein 7 2.65228
STIMATE STIM activating enhancer 2.6247
CYCS cytochrome c, somatic 2.57538
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.56272
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.49477
NCAPD2 non-SMC condensin I complex, subunit D2 2.45849
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.37966
RAB4A RAB4A, member RAS oncogene family 2.24902
EVL Enah/Vasp-like 2.20999
SFTPB surfactant protein B 2.18061
NOTCH1 notch 1 2.15825
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.1503
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.11455
LPAR2 lysophosphatidic acid receptor 2 2.05338
GPATCH8 G patch domain containing 8 2.0364
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.02247
WASF2 WAS protein family, member 2 2.00406

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.19484
ACLY ATP citrate lyase -3.89854
OXA1L oxidase (cytochrome c) assembly 1-like -3.80497
SPAG4 sperm associated antigen 4 -3.6786
PRPF4 pre-mRNA processing factor 4 -3.67061
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.58059
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.47112
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.85368
ARID5B AT rich interactive domain 5B (MRF1-like) -2.85154
ZNF586 zinc finger protein 586 -2.83201
DERA deoxyribose-phosphate aldolase (putative) -2.80982
CCNB1 cyclin B1 -2.79396
RAI14 retinoic acid induced 14 -2.54735
GNAS GNAS complex locus -2.48769
CCNB2 cyclin B2 -2.47944
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.46259
ZNF274 zinc finger protein 274 -2.32802
MAPK13 mitogen-activated protein kinase 13 -2.32544
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.29691
WDR7 WD repeat domain 7 -2.23862
BIRC2 baculoviral IAP repeat containing 2 -2.16952
ALAS1 5'-aminolevulinate synthase 1 -2.07596
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.06055