CRCGN014_HEPG2_3H:H04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methacrylonitrile 41.8 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN014_HEPG2_3H:H04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.59614
GPATCH8 G patch domain containing 8 5.3735
CEP57 centrosomal protein 57kDa 3.84272
TREM1 triggering receptor expressed on myeloid cells 1 3.37307
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.32115
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.21425
MAP7 microtubule-associated protein 7 3.11828
BACE2 beta-site APP-cleaving enzyme 2 2.99476
E2F2 E2F transcription factor 2 2.94541
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.8979
NOTCH1 notch 1 2.75107
CCDC92 coiled-coil domain containing 92 2.69482
STK10 serine/threonine kinase 10 2.67006
KIF14 kinesin family member 14 2.63521
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.62985
CHMP6 charged multivesicular body protein 6 2.57573
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.53739
ANKRD49 ankyrin repeat domain 49 2.51478
PRKCH protein kinase C, eta 2.48871
NOSIP nitric oxide synthase interacting protein 2.37637
TLR4 toll-like receptor 4 2.34065
LYN LYN proto-oncogene, Src family tyrosine kinase 2.32647
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.31196
STIMATE STIM activating enhancer 2.30338
DIPK1A divergent protein kinase domain 1A 2.30021
CYCS cytochrome c, somatic 2.25064
CORO1A coronin, actin binding protein, 1A 2.22445
CD302 CD302 molecule 2.22344
CARMIL1 capping protein regulator and myosin 1 linker 1 2.19883
RPL36A ribosomal protein L36a 2.19762
CCNF cyclin F 2.18367
RETREG3 reticulophagy regulator family member 3 2.12426
CXCL2 chemokine (C-X-C motif) ligand 2 2.12187
WASF3 WAS protein family, member 3 2.08767
RPL18A ribosomal protein L18a 2.08509
COPS7A COP9 signalosome subunit 7A 2.06899
PARL presenilin associated, rhomboid-like 2.06778

decreased expression

Symbol Name Standardized Value
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.70121
OXA1L oxidase (cytochrome c) assembly 1-like -5.61082
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.27338
PCNA proliferating cell nuclear antigen -3.67974
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.58583
CCNB2 cyclin B2 -3.40811
ZNF586 zinc finger protein 586 -3.21099
GTPBP8 GTP-binding protein 8 (putative) -3.19626
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.16201
VAT1 vesicle amine transport 1 -2.98953
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.90848
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.72133
LDHD lactate dehydrogenase D -2.68443
CTSD cathepsin D -2.63106
CSK c-src tyrosine kinase -2.62787
BAMBI BMP and activin membrane-bound inhibitor -2.28409
SLC35F2 solute carrier family 35, member F2 -2.14759
TMEM106B transmembrane protein 106B -2.09218
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.08859
EIF5 eukaryotic translation initiation factor 5 -2.06619