CRCGN014_HEPG2_3H:H07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description BRD-K88965984 40.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

68 genes differentially expressed following the CRCGN014_HEPG2_3H:H07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 7.33595
UBQLN2 ubiquilin 2 7.21786
TIAM1 T-cell lymphoma invasion and metastasis 1 6.90938
PPARG peroxisome proliferator-activated receptor gamma 6.85051
KCNK1 potassium channel, two pore domain subfamily K, member 1 5.73213
STIMATE STIM activating enhancer 5.49389
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 5.0453
C2CD2 C2 calcium-dependent domain containing 2 4.06692
CHMP6 charged multivesicular body protein 6 3.78317
CARMIL1 capping protein regulator and myosin 1 linker 1 3.65011
SNAP25 synaptosomal-associated protein, 25kDa 3.5582
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.49664
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.47887
CXCL2 chemokine (C-X-C motif) ligand 2 3.24497
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.21106
GPER1 G protein-coupled estrogen receptor 1 3.20873
CCNF cyclin F 3.20642
AMDHD2 amidohydrolase domain containing 2 3.16524
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.07724
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.04485
GSTZ1 glutathione S-transferase zeta 1 3.03707
ADGRE5 adhesion G protein-coupled receptor E5 2.97194
MAMLD1 mastermind-like domain containing 1 2.96969
HOXA10 homeobox A10 2.84452
FZD7 frizzled class receptor 7 2.83462
BACE2 beta-site APP-cleaving enzyme 2 2.75875
CIAO3 cytosolic iron-sulfur assembly component 3 2.67642
VAV3 vav 3 guanine nucleotide exchange factor 2.65177
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.61422
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.45693
DENND2D DENN/MADD domain containing 2D 2.44009
GPATCH8 G patch domain containing 8 2.41398
ILK integrin-linked kinase 2.36698
SLC75A1 solute carrier family 75 member 1 2.33598
HYOU1 hypoxia up-regulated 1 2.31206
STXBP1 syntaxin binding protein 1 2.22791
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.16723
LCN2 lipocalin 2 2.1449
EPHA3 EPH receptor A3 2.13884
LIPC lipase, hepatic 2.10985
LPAR2 lysophosphatidic acid receptor 2 2.04111

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.48782
ZNF586 zinc finger protein 586 -5.49906
ADI1 acireductone dioxygenase 1 -3.7618
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.68143
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.65011
DCK deoxycytidine kinase -3.60665
BPHL biphenyl hydrolase-like (serine hydrolase) -3.52478
TRAPPC3 trafficking protein particle complex 3 -3.3829
ARID5B AT rich interactive domain 5B (MRF1-like) -3.23624
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.22346
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.99339
LDHD lactate dehydrogenase D -2.81524
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.79143
TLR4 toll-like receptor 4 -2.77269
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.72883
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.48788
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 -2.27457
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -2.25828
FOS FBJ murine osteosarcoma viral oncogene homolog -2.24838
RCE1 Ras converting CAAX endopeptidase 1 -2.19904
IGF2R insulin-like growth factor 2 receptor -2.16392
AIRIM AFG2 interacting ribosome maturation factor -2.15484
MAPK13 mitogen-activated protein kinase 13 -2.08987
ARRB2 arrestin, beta 2 -2.06219
TBC1D31 TBC1 domain family, member 31 -2.05669
ZBTB39 zinc finger and BTB domain containing 39 -2.0352
CCNJ cyclin J -2.0112