CRCGN014_HEPG2_3H:H08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-[2,2-dichloro-1-(4-ethylphenyl)ethyl]-4-ethylbenzene 40.6 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

65 genes differentially expressed following the CRCGN014_HEPG2_3H:H08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DDIT4 DNA-damage-inducible transcript 4 8.32811
PPARG peroxisome proliferator-activated receptor gamma 6.52738
EGR1 early growth response 1 6.3325
IER3 immediate early response 3 4.91363
TREM1 triggering receptor expressed on myeloid cells 1 3.98433
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.96899
DIPK1A divergent protein kinase domain 1A 3.62419
TRIB1 tribbles pseudokinase 1 3.49116
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.43489
RPL39L ribosomal protein L39-like 3.35565
ILK integrin-linked kinase 3.05538
FOSL1 FOS-like antigen 1 2.99559
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.93504
E2F2 E2F transcription factor 2 2.89933
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.83287
CBR3 carbonyl reductase 3 2.76588
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.68384
ICAM1 intercellular adhesion molecule 1 2.63057
CXCR4 chemokine (C-X-C motif) receptor 4 2.61162
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 2.599
ZFP36 ZFP36 ring finger protein 2.55515
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.55248
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 2.48071
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast) 2.44105
RHOA ras homolog family member A 2.41791
BACE2 beta-site APP-cleaving enzyme 2 2.36729
NOSIP nitric oxide synthase interacting protein 2.34804
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.16734
ANO1 anoctamin 1, calcium activated chloride channel 2.14607
HBEGF heparin-binding EGF-like growth factor 2.14027
TIAM1 T-cell lymphoma invasion and metastasis 1 2.13756
SYNM synemin, intermediate filament protein 2.13598
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.06506
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 2.06449
ZNF589 zinc finger protein 589 2.04574
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.04189

decreased expression

Symbol Name Standardized Value
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -6.95991
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.20343
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -5.36595
COG2 component of oligomeric golgi complex 2 -3.92019
CDC25B cell division cycle 25B -3.78943
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.72206
LDHD lactate dehydrogenase D -3.43557
FGFR4 fibroblast growth factor receptor 4 -2.88233
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.86442
TBC1D31 TBC1 domain family, member 31 -2.80121
TXNDC9 thioredoxin domain containing 9 -2.73509
LYPLA1 lysophospholipase I -2.68006
TBX2 T-box 2 -2.60018
NGRN neugrin, neurite outgrowth associated -2.52728
CD58 CD58 molecule -2.41441
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.3941
SLC35F2 solute carrier family 35, member F2 -2.32703
EIF5 eukaryotic translation initiation factor 5 -2.30654
PDHX pyruvate dehydrogenase complex, component X -2.30042
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 -2.18447
FZD6 frizzled class receptor 6 -2.15213
TNRC6B trinucleotide repeat containing 6B -2.12329
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.11293
RHEB Ras homolog enriched in brain -2.09892
APIP APAF1 interacting protein -2.07763
CAAP1 caspase activity and apoptosis inhibitor 1 -2.0683
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.03743
TGFB3 transforming growth factor, beta 3 -2.0373
AP5M1 adaptor-related protein complex 5, mu 1 subunit -2.02915