CRCGN014_HEPG2_3H:H11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description scopolamine hydrobromide tri-hydrate 40.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

70 genes differentially expressed following the CRCGN014_HEPG2_3H:H11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 5.32921
STIMATE STIM activating enhancer 4.63218
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.44659
MYLK myosin light chain kinase 4.33383
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.88264
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.63031
TIAM1 T-cell lymphoma invasion and metastasis 1 3.59483
JADE2 jade family PHD finger 2 3.20787
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.15909
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 3.11389
SSBP2 single-stranded DNA binding protein 2 3.0944
CASP10 caspase 10, apoptosis-related cysteine peptidase 3.03755
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.00661
SREK1 splicing regulatory glutamine/lysine-rich protein 1 2.90501
FAIM Fas apoptotic inhibitory molecule 2.75588
LCN2 lipocalin 2 2.71774
HLA-DRA major histocompatibility complex, class II, DR alpha 2.64514
NOSIP nitric oxide synthase interacting protein 2.59179
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.57478
LAGE3 L antigen family, member 3 2.42292
SMIM44 small integral membrane protein 44 2.35647
CD40 CD40 molecule, TNF receptor superfamily member 5 2.3419
LTA lymphotoxin alpha 2.29509
GPER1 G protein-coupled estrogen receptor 1 2.26334
PARP3 poly (ADP-ribose) polymerase family, member 3 2.24434
OR7A17 olfactory receptor, family 7, subfamily A, member 17 2.22257
TPD52L2 tumor protein D52-like 2 2.21647
STX11 syntaxin 11 2.15023
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.14974
TMOD1 tropomodulin 1 2.14867
BMP4 bone morphogenetic protein 4 2.14536
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.13719
ANGPTL7 angiopoietin-like 7 2.12371
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 2.10743
OR1E2 olfactory receptor, family 1, subfamily E, member 2 2.08021
MCUB mitochondrial calcium uniporter dominant negative subunit beta 2.04958
NUCB2 nucleobindin 2 2.04549
NEIL1 nei endonuclease VIII-like 1 (E. coli) 2.02323
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.00333
VIM vimentin 2.0033

decreased expression

Symbol Name Standardized Value
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -6.67074
TM9SF3 transmembrane 9 superfamily member 3 -5.3015
CDC20 cell division cycle 20 -4.75483
GOLT1B golgi transport 1B -4.69495
PLK1 polo-like kinase 1 -4.65904
CHMP4B charged multivesicular body protein 4B -4.56813
CCNB2 cyclin B2 -4.38234
MAPK13 mitogen-activated protein kinase 13 -4.16594
WDR7 WD repeat domain 7 -3.57634
NGRN neugrin, neurite outgrowth associated -3.48952
ZMIZ1 zinc finger, MIZ-type containing 1 -3.4179
FGFR4 fibroblast growth factor receptor 4 -3.38389
MTFR1 mitochondrial fission regulator 1 -3.25667
AVPI1 arginine vasopressin-induced 1 -2.61494
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.43008
GCLC glutamate-cysteine ligase, catalytic subunit -2.39759
BRMS1L breast cancer metastasis-suppressor 1-like -2.32491
SH3YL1 SH3 and SYLF domain containing 1 -2.25505
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.22154
NUSAP1 nucleolar and spindle associated protein 1 -2.19826
PEG10 paternally expressed 10 -2.18289
DAAM1 dishevelled associated activator of morphogenesis 1 -2.17863
EMILIN1 elastin microfibril interfacer 1 -2.17225
RND1 Rho family GTPase 1 -2.15343
MRPL37 mitochondrial ribosomal protein L37 -2.12437
ELP3 elongator acetyltransferase complex subunit 3 -2.09753
HGS hepatocyte growth factor-regulated tyrosine kinase substrate -2.05522
RGS2 regulator of G-protein signaling 2 -2.03776
REEP5 receptor accessory protein 5 -2.0162
SH2D2A SH2 domain containing 2A -2.01523