| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | endosulfan 40.0 um perturbation at 3 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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211 genes differentially expressed following the CRCGN014_HEPG2_3H:H13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DDIT4 | DNA-damage-inducible transcript 4 | 10.0 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 10.0 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 7.77249 |
| EGR1 | early growth response 1 | 7.64216 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 6.90864 |
| UBQLN2 | ubiquilin 2 | 6.86836 |
| IER3 | immediate early response 3 | 6.85223 |
| HSPA1A | heat shock 70kDa protein 1A | 6.77015 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 6.46437 |
| ZFP36 | ZFP36 ring finger protein | 6.34608 |
| JUN | jun proto-oncogene | 5.55566 |
| FOSL1 | FOS-like antigen 1 | 5.51932 |
| TRIB1 | tribbles pseudokinase 1 | 5.44418 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 5.36351 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 4.83407 |
| TRIB3 | tribbles pseudokinase 3 | 4.60012 |
| SKIC8 | SKI8 subunit of superkiller complex | 4.47559 |
| H2BC12 | H2B clustered histone 12 | 4.14035 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 4.06305 |
| IER2 | immediate early response 2 | 4.02324 |
| TCFL5 | transcription factor-like 5 (basic helix-loop-helix) | 4.00042 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 3.75322 |
| LPAR2 | lysophosphatidic acid receptor 2 | 3.66682 |
| SQSTM1 | sequestosome 1 | 3.44381 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 3.4251 |
| DUSP6 | dual specificity phosphatase 6 | 3.42358 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 3.38431 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 3.34428 |
| MX1 | MX dynamin-like GTPase 1 | 3.30618 |
| ICAM1 | intercellular adhesion molecule 1 | 3.27572 |
| PRR15L | proline rich 15-like | 3.2629 |
| KIFBP | kinesin family binding protein | 3.20085 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 3.14498 |
| LOC128125814 | uncharacterized LOC128125814 | 3.1173 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 3.01491 |
| CCL2 | chemokine (C-C motif) ligand 2 | 3.01465 |
| HYOU1 | hypoxia up-regulated 1 | 2.93211 |
| CYCS | cytochrome c, somatic | 2.92994 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 2.91089 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 2.88034 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 2.86869 |
| CCNE2 | cyclin E2 | 2.865 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 2.83677 |
| EGR3 | early growth response 3 | 2.80568 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 2.80053 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 2.78751 |
| RGS2 | regulator of G-protein signaling 2 | 2.77417 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 2.75524 |
| IL4R | interleukin 4 receptor | 2.70017 |
| INPP1 | inositol polyphosphate-1-phosphatase | 2.66763 |
| ATF3 | activating transcription factor 3 | 2.66694 |
| STX5 | syntaxin 5 | 2.66408 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | 2.65047 |
| CSK | c-src tyrosine kinase | 2.64538 |
| SCRN1 | secernin 1 | 2.6295 |
| IFI44L | interferon-induced protein 44-like | 2.61248 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | 2.60986 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 2.59849 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 2.59231 |
| FHL2 | four and a half LIM domains 2 | 2.55409 |
| ISG15 | ISG15 ubiquitin-like modifier | 2.5354 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 2.50761 |
| SSBP2 | single-stranded DNA binding protein 2 | 2.47277 |
| PAMR1 | peptidase domain containing associated with muscle regeneration 1 | 2.46924 |
| DUSP8 | dual specificity phosphatase 8 | 2.45644 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 2.45471 |
| CEBPZ | CCAAT/enhancer binding protein (C/EBP), zeta | 2.44349 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 2.43449 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 2.37989 |
| GSTZ1 | glutathione S-transferase zeta 1 | 2.35947 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 2.34945 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 2.31501 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 2.30902 |
| EGF | epidermal growth factor | 2.27796 |
| CHEK2 | checkpoint kinase 2 | 2.27045 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 | 2.26033 |
| BTG2 | BTG family, member 2 | 2.25288 |
| RHBDF1 | rhomboid 5 homolog 1 (Drosophila) | 2.22614 |
| GPATCH8 | G patch domain containing 8 | 2.20381 |
| BACE1 | beta-site APP-cleaving enzyme 1 | 2.17457 |
| MX2 | MX dynamin-like GTPase 2 | 2.16784 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 2.16595 |
| KLF2 | Kruppel-like factor 2 | 2.16311 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | 2.1465 |
| HSPA1B | heat shock 70kDa protein 1B | 2.14099 |
| CDK19 | cyclin-dependent kinase 19 | 2.12779 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 2.12313 |
| HTR2B | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled | 2.11518 |
| ANKRA2 | ankyrin repeat, family A (RFXANK-like), 2 | 2.11109 |
| ZNF93 | zinc finger protein 93 | 2.1083 |
| MNT | MAX network transcriptional repressor | 2.09236 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 2.08247 |
| FAM13A | family with sequence similarity 13, member A | 2.07814 |
| ARMCX3 | armadillo repeat containing, X-linked 3 | 2.06456 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 2.06376 |
| TRAF4 | TNF receptor-associated factor 4 | 2.06241 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 2.05993 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 2.04881 |
| TMSB15B | thymosin beta 15B | 2.04594 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 2.04425 |
| RLF | rearranged L-myc fusion | 2.04075 |
| BCKDHA | branched chain keto acid dehydrogenase E1, alpha polypeptide | 2.04054 |
| IRF7 | interferon regulatory factor 7 | 2.02963 |
| SAR1B | secretion associated, Ras related GTPase 1B | 2.02774 |
| COMMD10 | COMM domain containing 10 | 2.02237 |
| RBM15B | RNA binding motif protein 15B | 2.01965 |
| NCK1 | NCK adaptor protein 1 | 2.00433 |
| CDKL3 | cyclin-dependent kinase-like 3 | 2.00077 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FASTKD5 | FAST kinase domains 5 | -7.77159 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | -7.19558 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -6.7276 |
| BLCAP | bladder cancer associated protein | -6.48181 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -6.45272 |
| CCNB2 | cyclin B2 | -6.20539 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -5.89015 |
| THAP11 | THAP domain containing 11 | -5.4342 |
| MAPK13 | mitogen-activated protein kinase 13 | -4.62022 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -4.45278 |
| GET1 | guided entry of tail-anchored proteins factor 1 | -4.35766 |
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | -4.18328 |
| MRPS16 | mitochondrial ribosomal protein S16 | -4.10513 |
| SLC35F2 | solute carrier family 35, member F2 | -4.05668 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -3.9974 |
| TLR4 | toll-like receptor 4 | -3.82483 |
| DERA | deoxyribose-phosphate aldolase (putative) | -3.71023 |
| LDHD | lactate dehydrogenase D | -3.69205 |
| TM9SF2 | transmembrane 9 superfamily member 2 | -3.65493 |
| MAT2A | methionine adenosyltransferase II, alpha | -3.57574 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.54644 |
| CDC20 | cell division cycle 20 | -3.54428 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -3.43819 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -3.43303 |
| COG7 | component of oligomeric golgi complex 7 | -3.41401 |
| LBR | lamin B receptor | -3.32198 |
| PARP1 | poly (ADP-ribose) polymerase 1 | -3.3149 |
| PROS1 | protein S (alpha) | -3.20731 |
| TBCB | tubulin folding cofactor B | -3.19867 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -3.13132 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | -3.02552 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | -2.99162 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | -2.94701 |
| NAGPA | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase | -2.90487 |
| NR2F6 | nuclear receptor subfamily 2, group F, member 6 | -2.85999 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | -2.81493 |
| POLR1A | polymerase (RNA) I polypeptide A, 194kDa | -2.78837 |
| PGAM4 | phosphoglycerate mutase family member 4 | -2.75121 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -2.72953 |
| PLOD3 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 | -2.72703 |
| NUP85 | nucleoporin 85kDa | -2.68421 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | -2.62961 |
| EDC4 | enhancer of mRNA decapping 4 | -2.59277 |
| ELAC2 | elaC ribonuclease Z 2 | -2.59161 |
| DPH2 | DPH2 homolog (S. cerevisiae) | -2.55425 |
| TXLNA | taxilin alpha | -2.54921 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -2.53965 |
| CST7 | cystatin F (leukocystatin) | -2.52998 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -2.51771 |
| LMO7 | LIM domain 7 | -2.47666 |
| GPATCH1 | G patch domain containing 1 | -2.4512 |
| SAMM50 | SAMM50 sorting and assembly machinery component | -2.44806 |
| SLC30A10 | solute carrier family 30, member 10 | -2.36643 |
| ANXA7 | annexin A7 | -2.33044 |
| GLOD4 | glyoxalase domain containing 4 | -2.32644 |
| TXNDC9 | thioredoxin domain containing 9 | -2.31957 |
| CEP131 | centrosomal protein 131kDa | -2.3084 |
| COA4 | cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) | -2.29229 |
| DNAJC9 | DnaJ (Hsp40) homolog, subfamily C, member 9 | -2.27375 |
| CRYZ | crystallin, zeta (quinone reductase) | -2.27207 |
| FASTKD1 | FAST kinase domains 1 | -2.27017 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -2.25834 |
| NLRP2B | NLR family pyrin domain containing 2B | -2.22095 |
| THAP12 | THAP domain containing 12 | -2.21864 |
| CLEC10A | C-type lectin domain family 10, member A | -2.2123 |
| OXLD1 | oxidoreductase-like domain containing 1 | -2.20521 |
| PCYT2 | phosphate cytidylyltransferase 2, ethanolamine | -2.20233 |
| TMEM94 | transmembrane protein 94 | -2.19491 |
| FN1 | fibronectin 1 | -2.19328 |
| VPS26A | vacuolar protein sorting 26 homolog A (S. pombe) | -2.19076 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -2.19001 |
| PSME2 | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | -2.18486 |
| DNM1L | dynamin 1-like | -2.18116 |
| ZSCAN5A | zinc finger and SCAN domain containing 5A | -2.18062 |
| TLCD3A | TLC domain containing 3A | -2.17408 |
| CTSW | cathepsin W | -2.16874 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | -2.16061 |
| FGFR4 | fibroblast growth factor receptor 4 | -2.159 |
| TEDC2 | tubulin epsilon and delta complex 2 | -2.14233 |
| MOGS | mannosyl-oligosaccharide glucosidase | -2.14048 |
| UQCR10 | ubiquinol-cytochrome c reductase, complex III subunit X | -2.13927 |
| CCL15 | chemokine (C-C motif) ligand 15 | -2.13894 |
| TM7SF3 | transmembrane 7 superfamily member 3 | -2.13077 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.12752 |
| TSR3 | TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) | -2.0979 |
| ALG12 | ALG12, alpha-1,6-mannosyltransferase | -2.08511 |
| AGBL5 | ATP/GTP binding protein-like 5 | -2.08497 |
| RPIA | ribose 5-phosphate isomerase A | -2.083 |
| GTF2H4 | general transcription factor IIH, polypeptide 4, 52kDa | -2.073 |
| TRMT61B | tRNA methyltransferase 61B | -2.06825 |
| GPAA1 | glycosylphosphatidylinositol anchor attachment 1 | -2.06479 |
| TUBAL3 | tubulin, alpha-like 3 | -2.05579 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -2.04464 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -2.03561 |
| NCF1 | neutrophil cytosolic factor 1 | -2.03555 |
| UGDH | UDP-glucose 6-dehydrogenase | -2.01908 |
| PALB2 | partner and localizer of BRCA2 | -2.01852 |
| PYCR3 | pyrroline-5-carboxylate reductase 3 | -2.01564 |
| PIP4K2B | phosphatidylinositol-5-phosphate 4-kinase, type II, beta | -2.0148 |
| STK25 | serine/threonine kinase 25 | -2.01289 |
| TXNRD1 | thioredoxin reductase 1 | -2.01057 |
| TNNI2 | troponin I type 2 (skeletal, fast) | -2.00866 |
| TNNT3 | troponin T type 3 (skeletal, fast) | -2.00691 |
