CRCGN014_HEPG2_3H:H15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description bisphenol-a 39.6 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

571 genes differentially expressed following the CRCGN014_HEPG2_3H:H15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
BACE2 beta-site APP-cleaving enzyme 2 10.0
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 10.0
EPHB2 EPH receptor B2 10.0
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 9.8127
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 8.6553
PEX11A peroxisomal biogenesis factor 11 alpha 7.77325
CYCS cytochrome c, somatic 7.0015
JADE2 jade family PHD finger 2 6.3552
SYNGAP1 synaptic Ras GTPase activating protein 1 6.15595
ABHD6 abhydrolase domain containing 6 6.10957
GPATCH8 G patch domain containing 8 5.24305
SIRT3 sirtuin 3 5.04207
CYB561 cytochrome b561 4.7579
DIPK1A divergent protein kinase domain 1A 4.74375
MXRA7 matrix-remodelling associated 7 4.5752
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 4.5505
PRKCH protein kinase C, eta 4.30795
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.03645
STXBP1 syntaxin binding protein 1 3.849
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.8402
MCUR1 mitochondrial calcium uniporter regulator 1 3.8102
GZMM granzyme M (lymphocyte met-ase 1) 3.7219
DDIT4 DNA-damage-inducible transcript 4 3.6955
TRPM2 transient receptor potential cation channel, subfamily M, member 2 3.6425
LPAR2 lysophosphatidic acid receptor 2 3.614
DMBT1 deleted in malignant brain tumors 1 3.5575
OPRK1 opioid receptor, kappa 1 3.4383
DEFA6 defensin, alpha 6, Paneth cell-specific 3.425
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 3.4122
DCTN4 dynactin 4 (p62) 3.4004
AP3S2 adaptor-related protein complex 3, sigma 2 subunit 3.36787
FBXO31 F-box protein 31 3.2429
HLA-DMA major histocompatibility complex, class II, DM alpha 3.2418
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 3.2005
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 3.2003
LCN2 lipocalin 2 3.1381
APIP APAF1 interacting protein 3.1326
PPP1R16B protein phosphatase 1, regulatory subunit 16B 3.1135
GPA33 glycoprotein A33 (transmembrane) 3.068
GPD1L glycerol-3-phosphate dehydrogenase 1-like 3.0569
GATA2 GATA binding protein 2 3.0462
EVL Enah/Vasp-like 3.0096
KRT20 keratin 20, type I 2.9436
AOC1 amine oxidase, copper containing 1 2.8968
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 2.8836
PTTG1IP pituitary tumor-transforming 1 interacting protein 2.8825
GH1 growth hormone 1 2.85758
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 2.8441
CDX1 caudal type homeobox 1 2.8335
PIGP phosphatidylinositol glycan anchor biosynthesis, class P 2.8289
MRPL15 mitochondrial ribosomal protein L15 2.825
MTERF3 mitochondrial transcription termination factor 3 2.819
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 2.8129
UNC119B unc-119 homolog B (C. elegans) 2.7816
MFAP4 microfibrillar-associated protein 4 2.7664
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.7526
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 2.7489
CCL4 chemokine (C-C motif) ligand 4 2.7455
FHIP2B FHF complex subunit HOOK interacting protein 2B 2.7351
NOX1 NADPH oxidase 1 2.72353
STUM stum, mechanosensory transduction mediator homolog 2.7023
SHISAL1 shisa like 1 2.69855
INF2 inverted formin, FH2 and WH2 domain containing 2.6815
SORBS3 sorbin and SH3 domain containing 3 2.6734
PHOX2A paired-like homeobox 2a 2.6689
TRAPPC10 trafficking protein particle complex 10 2.64925
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 2.6469
NKX3-2 NK3 homeobox 2 2.643
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.6413
CRTAP cartilage associated protein 2.641
NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa 2.61255
CKB creatine kinase, brain 2.6027
DEFA5 defensin, alpha 5, Paneth cell-specific 2.6021
MED9 mediator complex subunit 9 2.6014
IPO7 importin 7 2.59932
LBP lipopolysaccharide binding protein 2.5854
GPRC5A G protein-coupled receptor, class C, group 5, member A 2.5789
GATA1 GATA binding protein 1 (globin transcription factor 1) 2.5743
TRAPPC4 trafficking protein particle complex 4 2.5646
CALY calcyon neuron-specific vesicular protein 2.5641
ZNF195 zinc finger protein 195 2.5617
BTG2 BTG family, member 2 2.55465
GAL3ST1 galactose-3-O-sulfotransferase 1 2.553
CLCA1 chloride channel accessory 1 2.544
NT5M 5',3'-nucleotidase, mitochondrial 2.5418
POM121 POM121 transmembrane nucleoporin 2.5381
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) 2.5381
NGRN neugrin, neurite outgrowth associated 2.5347
MISP mitotic spindle positioning 2.5276
CLIP3 CAP-GLY domain containing linker protein 3 2.5193
CDX2 caudal type homeobox 2 2.5081
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 2.4934
FABP1 fatty acid binding protein 1, liver 2.4931
TPSG1 tryptase gamma 1 2.4914
CCP110 centriolar coiled coil protein 110kDa 2.4914
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide 2.4881
IFITM1 interferon induced transmembrane protein 1 2.48735
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.4801
TIGAR TP53 induced glycolysis regulatory phosphatase 2.477
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.4687
ACVRL1 activin A receptor type II-like 1 2.4655
OLFM4 olfactomedin 4 2.4588
LAX1 lymphocyte transmembrane adaptor 1 2.4574
BTK Bruton agammaglobulinemia tyrosine kinase 2.4544
ASS1 argininosuccinate synthase 1 2.4508
CD177 CD177 molecule 2.4384
FANCF Fanconi anemia, complementation group F 2.437
RPP38 ribonuclease P/MRP 38kDa subunit 2.4364
GARRE1 granule associated Rac and RHOG effector 1 2.4269
ZDHHC3 zinc finger, DHHC-type containing 3 2.4254
SQOR sulfide quinone oxidoreductase 2.4216
HOXB1 homeobox B1 2.4147
NANOS2 nanos homolog 2 (Drosophila) 2.4081
PLS1 plastin 1 2.4064
LSM1 LSM1, U6 small nuclear RNA associated 2.4038
IL16 interleukin 16 2.4034
SLC41A3 solute carrier family 41, member 3 2.4027
CSH2 chorionic somatomammotropin hormone 2 2.4021
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 2.39845
MLH1 mutL homolog 1 2.3958
TGM4 transglutaminase 4 2.3935
MEX3C mex-3 RNA binding family member C 2.3896
PRRX2 paired related homeobox 2 2.3893
RCVRN recoverin 2.3869
UBE2N ubiquitin-conjugating enzyme E2N 2.3799
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.37737
STAB1 stabilin 1 2.3773
WSB2 WD repeat and SOCS box containing 2 2.3758
SRGN serglycin 2.37505
REG1A regenerating islet-derived 1 alpha 2.3704
CAPRIN1 cell cycle associated protein 1 2.3587
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 2.3575
FGFBP1 fibroblast growth factor binding protein 1 2.3565
FXYD5 FXYD domain containing ion transport regulator 5 2.3448
KLRG1 killer cell lectin-like receptor subfamily G, member 1 2.3351
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 2.33
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 2.3285
SH2D2A SH2 domain containing 2A 2.3256
ATP5PF ATP synthase peripheral stalk subunit F6 2.3245
ZXDC ZXD family zinc finger C 2.3179
CSHL1 chorionic somatomammotropin hormone-like 1 2.31753
ZFAND1 zinc finger, AN1-type domain 1 2.3113
LOC128966597 MAL-like protein 2.3084
TMEM50B transmembrane protein 50B 2.3025
TMPRSS2 transmembrane protease, serine 2 2.29245
SARS2 seryl-tRNA synthetase 2, mitochondrial 2.2896
LRRK1 leucine-rich repeat kinase 1 2.2877
USH1C Usher syndrome 1C (autosomal recessive, severe) 2.2751
NRL neural retina leucine zipper 2.271
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 2.27045
MINDY3 MINDY lysine 48 deubiquitinase 3 2.2693
TMEM41B transmembrane protein 41B 2.2671
LGALS14 lectin, galactoside-binding, soluble, 14 2.2657
CCL24 chemokine (C-C motif) ligand 24 2.2654
SMAD7 SMAD family member 7 2.2645
RNF113A ring finger protein 113A 2.2579
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.2577
RNF11 ring finger protein 11 2.2559
RIC8A RIC8 guanine nucleotide exchange factor A 2.2535
PTDSS2 phosphatidylserine synthase 2 2.2516
PACS2 phosphofurin acidic cluster sorting protein 2 2.2513
DAGLA diacylglycerol lipase, alpha 2.2499
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.24825
HIGD1A HIG1 hypoxia inducible domain family, member 1A 2.24175
ATP5MC3 ATP synthase membrane subunit c locus 3 2.23675
BDKRB1 bradykinin receptor B1 2.2348
SLCO2B1 solute carrier organic anion transporter family, member 2B1 2.2289
DGKQ diacylglycerol kinase, theta 110kDa 2.2281
MN1 meningioma (disrupted in balanced translocation) 1 2.2265
MTERF4 mitochondrial transcription termination factor 4 2.2143
MBOAT2 membrane bound O-acyltransferase domain containing 2 2.2108
PRX periaxin 2.2102
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 2.2075
CD8A CD8a molecule 2.2032
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 2.20272
UPK3A uroplakin 3A 2.2016
AXL AXL receptor tyrosine kinase 2.2003
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit 2.19663
CORO1A coronin, actin binding protein, 1A 2.1932
L1TD1 LINE-1 type transposase domain containing 1 2.1914
C1QB complement component 1, q subcomponent, B chain 2.188
RTCA RNA 3'-terminal phosphate cyclase 2.187
ZG16 zymogen granule protein 16 2.1821
FCGBP Fc fragment of IgG binding protein 2.1802
HAND1 heart and neural crest derivatives expressed 1 2.1781
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.1716
FN3KRP fructosamine 3 kinase related protein 2.167
EPM2AIP1 EPM2A (laforin) interacting protein 1 2.1634
NPY neuropeptide Y 2.1602
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 2.1581
GRM2 glutamate receptor, metabotropic 2 2.1577
RWDD3 RWD domain containing 3 2.1563
PODNL1 podocan-like 1 2.1551
PGP phosphoglycolate phosphatase 2.1539
EPS8L3 EPS8-like 3 2.1532
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 2.1509
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) 2.146
STMN2 stathmin 2 2.14455
CD24 CD24 molecule 2.14383
MROH7 maestro heat-like repeat family member 7 2.1413
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.1396
DND1 DND microRNA-mediated repression inhibitor 1 2.1324
TRAF3 TNF receptor-associated factor 3 2.1289
LIMD1 LIM domains containing 1 2.1217
RUNX3 runt-related transcription factor 3 2.11275
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6 2.1093
TRIM52 tripartite motif containing 52 2.1086
SLC66A3 solute carrier family 66 member 3 2.108
CCKAR cholecystokinin A receptor 2.1059
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 2.1026
CXCR3 chemokine (C-X-C motif) receptor 3 2.1019
CCDC87 coiled-coil domain containing 87 2.1003
CRYGC crystallin, gamma C 2.0999
DCP1A decapping mRNA 1A 2.0969
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 2.0852
DNMT1 DNA (cytosine-5-)-methyltransferase 1 2.0826
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase 2.0821
C1QA complement component 1, q subcomponent, A chain 2.0818
FSTL3 follistatin-like 3 (secreted glycoprotein) 2.0818
YJU2 YJU2 splicing factor homolog 2.0789
HOXB13 homeobox B13 2.0774
PDE9A phosphodiesterase 9A 2.0758
EEF1AKMT4-ECE2 EEF1AKMT4-ECE2 readthrough 2.0744
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 2.0686
RBM4B RNA binding motif protein 4B 2.0654
PYGM phosphorylase, glycogen, muscle 2.06
KBTBD11 kelch repeat and BTB (POZ) domain containing 11 2.0566
SIDT1 SID1 transmembrane family, member 1 2.0561
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 2.056
XPO7 exportin 7 2.05275
LHX5 LIM homeobox 5 2.0477
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) 2.0468
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 2.04543
CDK19 cyclin-dependent kinase 19 2.03953
MPHOSPH8 M-phase phosphoprotein 8 2.0372
VIL1 villin 1 2.0353
HEYL hes-related family bHLH transcription factor with YRPW motif-like 2.0319
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) 2.0309
ACOT11 acyl-CoA thioesterase 11 2.03035
DYNC2I1 dynein 2 intermediate chain 1 2.028
TMCC1 transmembrane and coiled-coil domain family 1 2.02737
ADRB3 adrenoceptor beta 3 2.0266
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) 2.0256
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7 2.02233
PARP11 poly (ADP-ribose) polymerase family, member 11 2.0212
GRK5 G protein-coupled receptor kinase 5 2.0208
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 2.0208
FAT4 FAT atypical cadherin 4 2.0177
HBZ hemoglobin, zeta 2.0167
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 2.01475
NACAD NAC alpha domain containing 2.0059
SPINK4 serine peptidase inhibitor, Kazal type 4 2.005
OLFM1 olfactomedin 1 2.00467
YIPF5 Yip1 domain family, member 5 2.0043
FNBP1L formin binding protein 1-like 2.0036
S1PR4 sphingosine-1-phosphate receptor 4 2.0012
PYDC1 PYD (pyrin domain) containing 1 2.0011

decreased expression

Symbol Name Standardized Value
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -10.0
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
MAPK13 mitogen-activated protein kinase 13 -8.6323
PGM1 phosphoglucomutase 1 -8.0333
PECR peroxisomal trans-2-enoyl-CoA reductase -7.9793
TLR4 toll-like receptor 4 -7.2082
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -5.7592
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -4.7772
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.6
EGF epidermal growth factor -4.4096
KIFBP kinesin family binding protein -4.2141
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -3.9599
BPHL biphenyl hydrolase-like (serine hydrolase) -3.9404
AZGP1 alpha-2-glycoprotein 1, zinc-binding -3.88795
EIF2D eukaryotic translation initiation factor 2D -3.7928
PIH1D1 PIH1 domain containing 1 -3.5581
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -3.5093
GSK3B glycogen synthase kinase 3 beta -3.4832
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -3.4776
PRDM13 PR domain containing 13 -3.4715
MSTN myostatin -3.4676
WRAP73 WD repeat containing, antisense to TP73 -3.4323
TBC1D31 TBC1 domain family, member 31 -3.4029
RNF167 ring finger protein 167 -3.3492
F13B coagulation factor XIII, B polypeptide -3.2996
PGR progesterone receptor -3.2826
RBM15 RNA binding motif protein 15 -3.2758
IARS1 isoleucyl-tRNA synthetase 1 -3.2246
FETUB fetuin B -3.186
COG2 component of oligomeric golgi complex 2 -3.1762
TGFB3 transforming growth factor, beta 3 -3.1726
TMEM254 transmembrane protein 254 -3.124
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated -3.1165
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) -3.0883
SMAD5 SMAD family member 5 -3.07465
PRRC1 proline-rich coiled-coil 1 -3.0575
TCHH trichohyalin -3.0459
UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10 -3.0263
ATP8B4 ATPase, class I, type 8B, member 4 -3.0212
TDO2 tryptophan 2,3-dioxygenase -2.9649
CDC73 cell division cycle 73 -2.9403
CENPT centromere protein T -2.9165
TRAK2 trafficking protein, kinesin binding 2 -2.914
GATA4 GATA binding protein 4 -2.8976
UBA1 ubiquitin-like modifier activating enzyme 1 -2.8792
PLA2G12A phospholipase A2, group XIIA -2.8598
INTS7 integrator complex subunit 7 -2.84925
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 -2.8406
CENPQ centromere protein Q -2.836
RAB5C RAB5C, member RAS oncogene family -2.83175
AP1AR adaptor-related protein complex 1 associated regulatory protein -2.8226
DNALI1 dynein, axonemal, light intermediate chain 1 -2.8155
PIPOX pipecolic acid oxidase -2.8136
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit -2.8083
TBC1D10B TBC1 domain family, member 10B -2.7771
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -2.7721
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 -2.77
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.7636
FNDC3B fibronectin type III domain containing 3B -2.7622
NBPF10 neuroblastoma breakpoint family, member 10 -2.7558
AASS aminoadipate-semialdehyde synthase -2.73905
EIF3B eukaryotic translation initiation factor 3, subunit B -2.71937
NECTIN2 nectin cell adhesion molecule 2 -2.7138
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 -2.6898
MAP2K1 mitogen-activated protein kinase kinase 1 -2.6876
HOXC10 homeobox C10 -2.6715
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 -2.6713
PSRC1 proline/serine-rich coiled-coil 1 -2.6506
DUSP14 dual specificity phosphatase 14 -2.6458
OTC ornithine carbamoyltransferase -2.6348
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -2.63425
ANXA10 annexin A10 -2.6311
SLC17A2 solute carrier family 17, member 2 -2.6293
METTL25B methyltransferase like 25B -2.6235
WWC2 WW and C2 domain containing 2 -2.6216
TGDS TDP-glucose 4,6-dehydratase -2.601
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -2.5984
AKR1D1 aldo-keto reductase family 1, member D1 -2.5982
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 -2.5976
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus -2.5961
WDR6 WD repeat domain 6 -2.5915
SALL1 spalt-like transcription factor 1 -2.5903
RNPEP arginyl aminopeptidase (aminopeptidase B) -2.57575
CYP3A7-CYP3A51P CYP3A7-CYP3A51P readthrough -2.5754
PON1 paraoxonase 1 -2.5734
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide -2.5718
CTDNEP1 CTD nuclear envelope phosphatase 1 -2.5702
EMX2 empty spiracles homeobox 2 -2.5697
LRRC17 leucine rich repeat containing 17 -2.5694
SNX16 sorting nexin 16 -2.5658
NRIP1 nuclear receptor interacting protein 1 -2.56195
SLC35F2 solute carrier family 35, member F2 -2.5538
DKK4 dickkopf WNT signaling pathway inhibitor 4 -2.553
GPR85 G protein-coupled receptor 85 -2.5507
SLC17A4 solute carrier family 17, member 4 -2.5492
CCL7 chemokine (C-C motif) ligand 7 -2.5464
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 -2.5457
GRIA3 glutamate receptor, ionotropic, AMPA 3 -2.54215
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 -2.5309
CYFIP1 cytoplasmic FMR1 interacting protein 1 -2.5297
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -2.5259
SLC38A2 solute carrier family 38, member 2 -2.51775
HAL histidine ammonia-lyase -2.51735
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 -2.5153
SGSH N-sulfoglucosamine sulfohydrolase -2.50945
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma -2.5056
DSG2 desmoglein 2 -2.5025
CCNL2 cyclin L2 -2.4984
RGS19 regulator of G-protein signaling 19 -2.4878
GK glycerol kinase -2.4841
WLS wntless Wnt ligand secretion mediator -2.482
MMUT methylmalonyl-CoA mutase -2.4812
PLS3 plastin 3 -2.4771
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 -2.4695
LCE2B late cornified envelope 2B -2.4623
DTWD1 DTW domain containing 1 -2.4618
PDZRN3 PDZ domain containing ring finger 3 -2.4559
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 -2.4558
CDH9 cadherin 9, type 2 (T1-cadherin) -2.4533
YARS1 tyrosyl-tRNA synthetase 1 -2.4504
CPEB3 cytoplasmic polyadenylation element binding protein 3 -2.4468
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 -2.4447
MTARC2 mitochondrial amidoxime reducing component 2 -2.436
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD) -2.4307
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A -2.4295
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 -2.4294
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 -2.4268
LARP4 La ribonucleoprotein domain family, member 4 -2.42135
EEA1 early endosome antigen 1 -2.42
AFM afamin -2.4164
ECI2 enoyl-CoA delta isomerase 2 -2.4118
CFHR3 complement factor H-related 3 -2.4088
RECQL RecQ helicase-like -2.405
TRPV2 transient receptor potential cation channel, subfamily V, member 2 -2.3986
FBXO5 F-box protein 5 -2.3958
UBE3C ubiquitin protein ligase E3C -2.3925
IL26 interleukin 26 -2.3839
MCUB mitochondrial calcium uniporter dominant negative subunit beta -2.3828
ETFDH electron-transferring-flavoprotein dehydrogenase -2.3815
CCNDBP1 cyclin D-type binding-protein 1 -2.3726
PLGLB2 plasminogen-like B2 -2.36995
ITGA1 integrin, alpha 1 -2.365
CDSN corneodesmosin -2.35855
HOXB3 homeobox B3 -2.3579
ANGPTL3 angiopoietin-like 3 -2.3547
HNMT histamine N-methyltransferase -2.35457
KLHDC8A kelch domain containing 8A -2.3535
ZNF234 zinc finger protein 234 -2.3469
APOF apolipoprotein F -2.3395
RPE65 retinal pigment epithelium-specific protein 65kDa -2.3349
PARK7 parkinson protein 7 -2.3343
CLCN5 chloride channel, voltage-sensitive 5 -2.3334
TIPRL TOR signaling pathway regulator -2.3269
GALR1 galanin receptor 1 -2.3264
DXO decapping exoribonuclease -2.32533
ZNF225 zinc finger protein 225 -2.325
NDP Norrie disease (pseudoglioma) -2.325
F2RL2 coagulation factor II (thrombin) receptor-like 2 -2.3247
RNF32 ring finger protein 32 -2.3238
ANKRD44 ankyrin repeat domain 44 -2.3231
ARRB2 arrestin, beta 2 -2.3227
DPYS dihydropyrimidinase -2.3123
IQCC IQ motif containing C -2.31
PAH phenylalanine hydroxylase -2.3066
ONECUT1 one cut homeobox 1 -2.3062
DNAI7 dynein axonemal intermediate chain 7 -2.3044
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -2.3038
AKR1C4 aldo-keto reductase family 1, member C4 -2.302
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 -2.302
NBPF3 neuroblastoma breakpoint family, member 3 -2.2997
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 -2.297
KDM5C lysine (K)-specific demethylase 5C -2.2896
CMTR1 cap methyltransferase 1 -2.2873
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 -2.2858
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 -2.2844
POLR1F RNA polymerase I subunit F -2.2829
MAGEA11 melanoma antigen family A11 -2.2821
SMC5 structural maintenance of chromosomes 5 -2.27765
RGN regucalcin -2.2757
FOXL2 forkhead box L2 -2.2757
TUFT1 tuftelin 1 -2.273
GAN gigaxonin -2.2646
RNLS renalase, FAD-dependent amine oxidase -2.2546
INHBE inhibin, beta E -2.2517
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 -2.2509
CDO1 cysteine dioxygenase type 1 -2.2493
DCAF17 DDB1 and CUL4 associated factor 17 -2.243
UBE2W ubiquitin-conjugating enzyme E2W (putative) -2.2428
GPATCH2L G patch domain containing 2-like -2.2391
DAZL deleted in azoospermia-like -2.2382
PARG poly (ADP-ribose) glycohydrolase -2.2376
EPHA7 EPH receptor A7 -2.2352
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 -2.2322
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -2.2267
ZNF512B zinc finger protein 512B -2.22575
NUP62CL nucleoporin 62kDa C-terminal like -2.2254
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 -2.2233
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa -2.2222
GSAP gamma-secretase activating protein -2.22055
NLRP4 NLR family, pyrin domain containing 4 -2.212
HABP2 hyaluronan binding protein 2 -2.2119
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -2.2107
TRIM49B tripartite motif containing 49B -2.2091
MROH9 maestro heat-like repeat family member 9 -2.2089
COL4A5 collagen, type IV, alpha 5 -2.2081
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -2.2053
CAPZB capping protein (actin filament) muscle Z-line, beta -2.20197
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase -2.1963
ECHDC2 enoyl CoA hydratase domain containing 2 -2.1959
CPNE2 copine II -2.1942
DSCC1 DNA replication and sister chromatid cohesion 1 -2.1913
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 -2.1904
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 -2.1903
ANO3 anoctamin 3 -2.1869
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) -2.1806
USP9X ubiquitin specific peptidase 9, X-linked -2.1782
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 -2.1774
POLI polymerase (DNA directed) iota -2.1754
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 -2.1716
CLPTM1 cleft lip and palate associated transmembrane protein 1 -2.17145
PLG plasminogen -2.17015
FAM111A family with sequence similarity 111, member A -2.1689
SPDEF SAM pointed domain containing ETS transcription factor -2.16783
BHMT betaine--homocysteine S-methyltransferase -2.1614
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 -2.1608
PPP4C protein phosphatase 4, catalytic subunit -2.1606
PPP1R3A protein phosphatase 1, regulatory subunit 3A -2.1548
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -2.1513
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa -2.1506
CENPI centromere protein I -2.15035
XPO1 exportin 1 -2.1499
SSBP2 single-stranded DNA binding protein 2 -2.14785
NBPF19 neuroblastoma breakpoint family, member 19 -2.1473
THAP9 THAP domain containing 9 -2.1459
PLK4 polo-like kinase 4 -2.14527
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -2.14493
PROX1 prospero homeobox 1 -2.1442
IP6K1 inositol hexakisphosphate kinase 1 -2.1383
E2F8 E2F transcription factor 8 -2.1319
GPR176 G protein-coupled receptor 176 -2.1318
GASK1B golgi associated kinase 1B -2.1286
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa -2.12775
RNF40 ring finger protein 40, E3 ubiquitin protein ligase -2.1226
FXR2 fragile X mental retardation, autosomal homolog 2 -2.12085
KDM6A lysine (K)-specific demethylase 6A -2.12033
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 -2.119
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit -2.1179
LTA lymphotoxin alpha -2.1178
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 -2.1164
EXOSC10 exosome component 10 -2.1151
EHD4 EH-domain containing 4 -2.1148
TMED9 transmembrane emp24 protein transport domain containing 9 -2.1144
SCGB2A2 secretoglobin, family 2A, member 2 -2.1132
IRS1 insulin receptor substrate 1 -2.1119
FST follistatin -2.1114
ZNF559-ZNF177 ZNF559-ZNF177 readthrough -2.1113
LIMS1 LIM and senescent cell antigen-like domains 1 -2.1084
G6PC1 glucose-6-phosphatase catalytic subunit 1 -2.1072
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase -2.1053
ARHGAP26 Rho GTPase activating protein 26 -2.10363
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 -2.103
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 -2.10245
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -2.1019
IFT46 intraflagellar transport 46 -2.1013
CEP76 centrosomal protein 76kDa -2.0997
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 -2.0835
RPGRIP1L RPGRIP1-like -2.0832
CHMP1A charged multivesicular body protein 1A -2.0823
CFAP43 cilia and flagella associated protein 43 -2.0784
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) -2.0777
WDR41 WD repeat domain 41 -2.0766
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -2.0748
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 -2.0747
CXCL5 chemokine (C-X-C motif) ligand 5 -2.073
SPACA1 sperm acrosome associated 1 -2.0717
MBL2 mannose-binding lectin (protein C) 2, soluble -2.0713
VLDLR very low density lipoprotein receptor -2.0696
HSPA4L heat shock 70kDa protein 4-like -2.0674
LAMP2 lysosomal-associated membrane protein 2 -2.06657
TMBIM6 transmembrane BAX inhibitor motif containing 6 -2.06275
GLRB glycine receptor, beta -2.05625
ZNF471 zinc finger protein 471 -2.056
GAD1 glutamate decarboxylase 1 (brain, 67kDa) -2.05543
IL9 interleukin 9 -2.0527
DGKB diacylglycerol kinase, beta 90kDa -2.0504
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -2.0479
SPATA6 spermatogenesis associated 6 -2.0472
SORT1 sortilin 1 -2.0435
HOXB2 homeobox B2 -2.0421
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa -2.0372
AHCTF1 AT hook containing transcription factor 1 -2.0368
SF3B1 splicing factor 3b, subunit 1, 155kDa -2.03455
DLX2 distal-less homeobox 2 -2.03355
PBRM1 polybromo 1 -2.0329
PON3 paraoxonase 3 -2.0328
TNPO1 transportin 1 -2.0316
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 -2.0252
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 -2.0233
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 -2.023
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 -2.0213
WDHD1 WD repeat and HMG-box DNA binding protein 1 -2.01907
PDGFC platelet derived growth factor C -2.0166
DNAI4 dynein axonemal intermediate chain 4 -2.0165
VSIG2 V-set and immunoglobulin domain containing 2 -2.0143
HAO2 hydroxyacid oxidase 2 (long chain) -2.0138
CCL27 chemokine (C-C motif) ligand 27 -2.0104
TBC1D3G TBC1 domain family member 3G -2.0103
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -2.01027
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -2.0079
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -2.0046
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 -2.0042
FLNA filamin A, alpha -2.00227
SOX5 SRY (sex determining region Y)-box 5 -2.0016
GYS2 glycogen synthase 2 (liver) -2.0008