CRCGN014_HEPG2_3H:H18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (2-chloroethyl)trimethylammonium chloride 40.8 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

142 genes differentially expressed following the CRCGN014_HEPG2_3H:H18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 9.26648
ADRB2 adrenoceptor beta 2, surface 8.23471
CXCL2 chemokine (C-X-C motif) ligand 2 4.78989
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.29411
TIAM1 T-cell lymphoma invasion and metastasis 1 4.05809
FCHO1 FCH domain only 1 3.70434
CEP57 centrosomal protein 57kDa 3.63385
CCL2 chemokine (C-C motif) ligand 2 3.59436
STIMATE STIM activating enhancer 3.51135
CCP110 centriolar coiled coil protein 110kDa 3.5019
CYCS cytochrome c, somatic 3.46272
CNPY3 canopy FGF signaling regulator 3 3.44039
NOTCH1 notch 1 3.29148
BLMH bleomycin hydrolase 3.20908
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 3.2047
CHN1 chimerin 1 3.04612
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.01721
ZBTB18 zinc finger and BTB domain containing 18 2.89586
PKN1 protein kinase N1 2.84964
RAB31 RAB31, member RAS oncogene family 2.76532
ABHD6 abhydrolase domain containing 6 2.72468
SFTPB surfactant protein B 2.6986
CHMP6 charged multivesicular body protein 6 2.53823
LY86 lymphocyte antigen 86 2.50077
PZP pregnancy-zone protein 2.49192
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.39628
PRAF2 PRA1 domain family, member 2 2.39403
CTSL cathepsin L 2.3768
RPL39L ribosomal protein L39-like 2.31607
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 2.20384
ASRGL1 asparaginase like 1 2.19667
HOXA10 homeobox A10 2.18107
CCNF cyclin F 2.14105
NQO1 NAD(P)H dehydrogenase, quinone 1 2.11308
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.10346
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 2.08693
CAPN1 calpain 1, (mu/I) large subunit 2.07998
UXS1 UDP-glucuronate decarboxylase 1 2.04362
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 2.04284
CCDC92 coiled-coil domain containing 92 2.02276
TGFBR3 transforming growth factor, beta receptor III 2.01985
CCL21 chemokine (C-C motif) ligand 21 2.01048

decreased expression

Symbol Name Standardized Value
NGRN neugrin, neurite outgrowth associated -8.11834
TLR4 toll-like receptor 4 -7.4814
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -7.32023
CAB39 calcium binding protein 39 -5.74543
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.7708
LDHD lactate dehydrogenase D -4.61373
ARID5B AT rich interactive domain 5B (MRF1-like) -4.60112
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.54672
LOC124907782 dual specificity protein phosphatase 22 -3.59813
CALCRL calcitonin receptor-like -2.94215
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit -2.90875
DOCK3 dedicator of cytokinesis 3 -2.75033
ESM1 endothelial cell-specific molecule 1 -2.66903
TBC1D10C TBC1 domain family, member 10C -2.6647
CHEK1 checkpoint kinase 1 -2.66105
RPE65 retinal pigment epithelium-specific protein 65kDa -2.64015
FAM174B family with sequence similarity 174, member B -2.60813
WNT6 wingless-type MMTV integration site family, member 6 -2.58929
TMEM267 transmembrane protein 267 -2.54699
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 -2.53222
RYR1 ryanodine receptor 1 (skeletal) -2.523
MYCT1 myc target 1 -2.51582
IL10RA interleukin 10 receptor, alpha -2.51574
MSMO1 methylsterol monooxygenase 1 -2.50824
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.4957
SPARCL1 SPARC-like 1 (hevin) -2.48818
TTYH1 tweety family member 1 -2.48812
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D -2.47927
SORCS3 sortilin-related VPS10 domain containing receptor 3 -2.4168
MARCHF1 membrane associated ring-CH-type finger 1 -2.39342
PTPRK protein tyrosine phosphatase, receptor type, K -2.36507
ARL15 ADP-ribosylation factor-like 15 -2.355
C3AR1 complement component 3a receptor 1 -2.34989
REEP5 receptor accessory protein 5 -2.34782
CTNND2 catenin (cadherin-associated protein), delta 2 -2.3379
CLCN2 chloride channel, voltage-sensitive 2 -2.33326
PCDHB8 protocadherin beta 8 -2.31363
LBX1 ladybird homeobox 1 -2.30947
TRPC5 transient receptor potential cation channel, subfamily C, member 5 -2.30892
TMEM19 transmembrane protein 19 -2.30491
ANGPT2 angiopoietin 2 -2.29914
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -2.29799
RXFP3 relaxin/insulin-like family peptide receptor 3 -2.29563
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.28505
CBX8 chromobox homolog 8 -2.26091
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.26011
ZBTB6 zinc finger and BTB domain containing 6 -2.2593
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -2.25436
NR1H4 nuclear receptor subfamily 1, group H, member 4 -2.25393
ECT2 epithelial cell transforming 2 -2.25215
ULBP2 UL16 binding protein 2 -2.22051
RFX4 regulatory factor X, 4 (influences HLA class II expression) -2.21684
SERINC1 serine incorporator 1 -2.21442
APOLD1 apolipoprotein L domain containing 1 -2.20957
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) -2.20827
NLRP4 NLR family, pyrin domain containing 4 -2.20643
PPIAL4H peptidylprolyl isomerase A like 4H -2.20462
ASTN1 astrotactin 1 -2.20168
LRRC3 leucine rich repeat containing 3 -2.20127
DCAF1 DDB1 and CUL4 associated factor 1 -2.1968
ALDOC aldolase C, fructose-bisphosphate -2.19464
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.17094
ACYP2 acylphosphatase 2, muscle type -2.16644
MSTN myostatin -2.16196
PLEKHH3 pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 -2.14447
HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 -2.13547
CNTNAP3B contactin associated protein-like 3B -2.12784
LINC02854 long intergenic non-protein coding RNA 2854 -2.12362
GPR85 G protein-coupled receptor 85 -2.12045
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 -2.11677
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) -2.10978
ARL14 ADP-ribosylation factor-like 14 -2.10846
LOC124900193 uncharacterized LOC124900193 -2.09674
PCDHGA11 protocadherin gamma subfamily A, 11 -2.09664
NRDE2 NRDE-2, necessary for RNA interference, domain containing -2.09578
USH2A Usher syndrome 2A (autosomal recessive, mild) -2.08802
AGBL3 ATP/GTP binding protein-like 3 -2.08489
GUCY2C guanylate cyclase 2C -2.0809
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase -2.07523
KIF23 kinesin family member 23 -2.07325
IFNA8 interferon, alpha 8 -2.07317
MAP3K7CL MAP3K7 C-terminal like -2.06946
SPRYD7 SPRY domain containing 7 -2.06775
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -2.05831
CLDN7 claudin 7 -2.04178
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 -2.03804
DROSHA drosha, ribonuclease type III -2.03134
MYO1D myosin ID -2.02937
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 -2.02672
THAP9 THAP domain containing 9 -2.02346
OPN1MW3 opsin 1, medium wave sensitive 3 -2.02192
INHBB inhibin, beta B -2.01308
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -2.01072
STMN3 stathmin-like 3 -2.00783
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -2.00612
CAMTA2 calmodulin binding transcription activator 2 -2.00393
AFAP1 actin filament associated protein 1 -2.00305
RASA4B RAS p21 protein activator 4B -2.00296
TSHR thyroid stimulating hormone receptor -2.00208
ACE angiotensin I converting enzyme -2.00097