CRCGN014_HEPG2_3H:H20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5-(4-{2-[methyl(2-pyridinyl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione 21.82 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

60 genes differentially expressed following the CRCGN014_HEPG2_3H:H20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 7.16581
LCN2 lipocalin 2 5.90438
CARMIL1 capping protein regulator and myosin 1 linker 1 5.19711
CXCL2 chemokine (C-X-C motif) ligand 2 4.90403
TIMP2 TIMP metallopeptidase inhibitor 2 4.81302
CSK c-src tyrosine kinase 4.50469
CXCR4 chemokine (C-X-C motif) receptor 4 4.1815
ANO1 anoctamin 1, calcium activated chloride channel 4.17548
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.14049
LPAR2 lysophosphatidic acid receptor 2 3.4417
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.41349
KIF20A kinesin family member 20A 3.40979
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.25194
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.77954
SYNGAP1 synaptic Ras GTPase activating protein 1 2.76519
EGF epidermal growth factor 2.47881
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.47488
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.43192
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.41654
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.35528
RPP38 ribonuclease P/MRP 38kDa subunit 2.35372
CHD9NB CHD9 neighbor 2.33974
TIAM1 T-cell lymphoma invasion and metastasis 1 2.30444
NPDC1 neural proliferation, differentiation and control, 1 2.28718
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 2.26043
DCAF16 DDB1 and CUL4 associated factor 16 2.26021
FOXJ1 forkhead box J1 2.24896
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 2.22595
SLC25A40 solute carrier family 25, member 40 2.17889
PDCL3 phosducin-like 3 2.15606
WWC1 WW and C2 domain containing 1 2.12316
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 2.06974
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.06798
CFAP45 cilia and flagella associated protein 45 2.04681
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.0025

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -5.32681
ISOC1 isochorismatase domain containing 1 -4.84304
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.77185
CCNB2 cyclin B2 -4.66496
TLR4 toll-like receptor 4 -3.82127
BLCAP bladder cancer associated protein -3.82092
TLCD3A TLC domain containing 3A -3.56619
SNX11 sorting nexin 11 -3.39431
STAT1 signal transducer and activator of transcription 1, 91kDa -3.14232
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.07814
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.97155
BPHL biphenyl hydrolase-like (serine hydrolase) -2.52903
E4F1 E4F transcription factor 1 -2.45326
PECR peroxisomal trans-2-enoyl-CoA reductase -2.40676
RCL1 RNA terminal phosphate cyclase-like 1 -2.36832
GNG12 guanine nucleotide binding protein (G protein), gamma 12 -2.21586
GPR88 G protein-coupled receptor 88 -2.16972
RPL18A ribosomal protein L18a -2.14222
NAA60 N(alpha)-acetyltransferase 60, NatF catalytic subunit -2.08647
NRIP1 nuclear receptor interacting protein 1 -2.05262
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) -2.03852
UBAP1 ubiquitin associated protein 1 -2.03294
NUCB1 nucleobindin 1 -2.02841
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.00358
CCL4 chemokine (C-C motif) ligand 4 -2.00087