CRCGN014_HEPG2_3H:H22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dimpylate 20.91 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

50 genes differentially expressed following the CRCGN014_HEPG2_3H:H22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
EPHB2 EPH receptor B2 4.34162
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.02354
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.6921
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.64376
PPARG peroxisome proliferator-activated receptor gamma 3.39438
ABHD6 abhydrolase domain containing 6 3.35096
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.16698
NOSIP nitric oxide synthase interacting protein 3.00199
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.8728
CYCS cytochrome c, somatic 2.84712
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.77566
UBQLN2 ubiquilin 2 2.69566
RRAGA Ras-related GTP binding A 2.69235
PIH1D1 PIH1 domain containing 1 2.61189
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.60888
ANO10 anoctamin 10 2.58641
ADGRG1 adhesion G protein-coupled receptor G1 2.51149
CIAO3 cytosolic iron-sulfur assembly component 3 2.44433
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.42071
ATG7 autophagy related 7 2.35606
COPS7A COP9 signalosome subunit 7A 2.34036
FPGS folylpolyglutamate synthase 2.1183
GSTZ1 glutathione S-transferase zeta 1 2.08559
PLEK2 pleckstrin 2 2.06647
CCRL2 chemokine (C-C motif) receptor-like 2 2.03743
KIFBP kinesin family binding protein 2.01004

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
LDHD lactate dehydrogenase D -6.22727
SCAND1 SCAN domain containing 1 -3.65777
ELAC2 elaC ribonuclease Z 2 -3.65498
ADI1 acireductone dioxygenase 1 -3.44675
KDM3A lysine (K)-specific demethylase 3A -3.4069
LAP3 leucine aminopeptidase 3 -3.29772
ACAA1 acetyl-CoA acyltransferase 1 -3.01706
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.94246
ZNF586 zinc finger protein 586 -2.92652
WASHC4 WASH complex subunit 4 -2.86106
FGFR4 fibroblast growth factor receptor 4 -2.85117
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.78946
GOLT1B golgi transport 1B -2.67126
RNF167 ring finger protein 167 -2.56387
GNAS GNAS complex locus -2.56286
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.51637
HLA-DMA major histocompatibility complex, class II, DM alpha -2.42954
CCNB2 cyclin B2 -2.21565
OXA1L oxidase (cytochrome c) assembly 1-like -2.20719
SNX11 sorting nexin 11 -2.12911
TXNDC9 thioredoxin domain containing 9 -2.08527
FANCI Fanconi anemia, complementation group I -2.06383
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.0099