CRCGN014_HEPG2_3H:I01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetracycline 40.2 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN014_HEPG2_3H:I01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DDIT4 DNA-damage-inducible transcript 4 10.0
PPARG peroxisome proliferator-activated receptor gamma 6.26848
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.7875
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 5.43106
SHB Src homology 2 domain containing adaptor protein B 4.01205
LCN2 lipocalin 2 3.83598
INTS3 integrator complex subunit 3 3.75267
SNAP25 synaptosomal-associated protein, 25kDa 3.58768
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.57706
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.43917
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.37391
ANO1 anoctamin 1, calcium activated chloride channel 3.27985
KIF14 kinesin family member 14 3.25867
CSK c-src tyrosine kinase 3.20773
TRIB3 tribbles pseudokinase 3 3.15084
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 3.01395
AARS1 alanyl-tRNA synthetase 1 2.73449
MMP2 matrix metallopeptidase 2 2.64059
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.54432
CRTAP cartilage associated protein 2.31381
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.31343
COPS7A COP9 signalosome subunit 7A 2.14307
EGF epidermal growth factor 2.13568
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.13478
HAO2 hydroxyacid oxidase 2 (long chain) 2.13181
SCRN1 secernin 1 2.13069
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.11432
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.10887
CKAP4 cytoskeleton-associated protein 4 2.0908
ZFP69B ZFP69 zinc finger protein B 2.08967
CDA cytidine deaminase 2.03864
SFTPB surfactant protein B 2.01433
KIF20A kinesin family member 20A 2.00895
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.00697

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
CCNB2 cyclin B2 -6.39934
FASTKD5 FAST kinase domains 5 -3.61574
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.48718
HSPA1A heat shock 70kDa protein 1A -3.27847
UBE3C ubiquitin protein ligase E3C -3.2757
SNX11 sorting nexin 11 -3.24356
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.20071
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.01226
PRPF4 pre-mRNA processing factor 4 -2.91843
MRPS2 mitochondrial ribosomal protein S2 -2.73999
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.62327
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.56169
CAB39 calcium binding protein 39 -2.48671
HMOX1 heme oxygenase 1 -2.27446
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.27211
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.2433
KCTD13 potassium channel tetramerization domain containing 13 -2.13163
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.12926
RPL36 ribosomal protein L36 -2.12584
NRIP1 nuclear receptor interacting protein 1 -2.08831
RPS11 ribosomal protein S11 -2.07067
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.00681