CRCGN014_HEPG2_3H:I06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ITE 20.96 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN014_HEPG2_3H:I06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 6.4404
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.95816
HSPA1A heat shock 70kDa protein 1A 4.74141
SATB1 SATB homeobox 1 3.7449
CBR3 carbonyl reductase 3 3.49049
BACE2 beta-site APP-cleaving enzyme 2 3.36637
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.36448
RAP1GAP RAP1 GTPase activating protein 3.08514
CXCL2 chemokine (C-X-C motif) ligand 2 3.05299
MAP7 microtubule-associated protein 7 2.93713
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.85678
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.49884
CARMIL1 capping protein regulator and myosin 1 linker 1 2.37494
DIPK1A divergent protein kinase domain 1A 2.37189
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.33276
CD40 CD40 molecule, TNF receptor superfamily member 5 2.32352
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.29437
NOSIP nitric oxide synthase interacting protein 2.289
TREM1 triggering receptor expressed on myeloid cells 1 2.2217
SNAP25 synaptosomal-associated protein, 25kDa 2.21812
ABHD6 abhydrolase domain containing 6 2.20721
UBE2A ubiquitin-conjugating enzyme E2A 2.15486
CRTAP cartilage associated protein 2.15197
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 2.13016
PDGFA platelet-derived growth factor alpha polypeptide 2.10771
ZNF589 zinc finger protein 589 2.08294
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 2.07337
TEX10 testis expressed 10 2.01768

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -7.03637
PCNA proliferating cell nuclear antigen -6.75571
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -4.3325
TLCD3A TLC domain containing 3A -3.9269
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.46845
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -3.0871
SPAG4 sperm associated antigen 4 -3.06434
VAT1 vesicle amine transport 1 -2.87887
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.61463
TLR4 toll-like receptor 4 -2.61314
CCNB2 cyclin B2 -2.36045
TXNDC9 thioredoxin domain containing 9 -2.33078
CTNND1 catenin (cadherin-associated protein), delta 1 -2.13721
PECR peroxisomal trans-2-enoyl-CoA reductase -2.10917