CRCGN014_HEPG2_3H:I07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description disodium 2-({4-[ethyl(3-sulfonatobenzyl)amino]phenyl}{4-[ethyl(3-sulfonatobenzyl)iminio]-2,5-cyclohexadien-1-ylidene}methyl)-5-hydroxybenzenesulfonate 20.28 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

55 genes differentially expressed following the CRCGN014_HEPG2_3H:I07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 7.18262
CCNF cyclin F 4.90153
LCN2 lipocalin 2 4.72927
SQOR sulfide quinone oxidoreductase 3.91672
VGLL4 vestigial-like family member 4 3.87926
EPHB2 EPH receptor B2 3.73776
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.43147
DIPK1A divergent protein kinase domain 1A 3.15482
CSK c-src tyrosine kinase 2.88974
PLSCR3 phospholipid scramblase 3 2.79468
SATB1 SATB homeobox 1 2.6744
TPD52L2 tumor protein D52-like 2 2.62362
GPER1 G protein-coupled estrogen receptor 1 2.52107
ATP11B ATPase, class VI, type 11B 2.4661
CBR1 carbonyl reductase 1 2.45208
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.44234
PLSCR1 phospholipid scramblase 1 2.42147
PKN1 protein kinase N1 2.33333
GNG5 guanine nucleotide binding protein (G protein), gamma 5 2.25913
MX1 MX dynamin-like GTPase 1 2.22807
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.22501
EGF epidermal growth factor 2.21301
NHP2 NHP2 ribonucleoprotein 2.16132
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.10479
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.05165
TPX2 TPX2, microtubule-associated 2.04681
KLK6 kallikrein-related peptidase 6 2.03607
ALOX15 arachidonate 15-lipoxygenase 2.02222
CTDNEP1 CTD nuclear envelope phosphatase 1 2.01944
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 2.01588
IFI44 interferon-induced protein 44 2.00572

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -7.2704
LDHD lactate dehydrogenase D -5.94378
TM9SF3 transmembrane 9 superfamily member 3 -4.11687
DNM1L dynamin 1-like -4.01478
OXA1L oxidase (cytochrome c) assembly 1-like -3.9509
C2CD5 C2 calcium-dependent domain containing 5 -3.64307
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.57853
EIF5 eukaryotic translation initiation factor 5 -3.42767
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.37839
CCNB1 cyclin B1 -3.29045
ZNF586 zinc finger protein 586 -3.06085
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.65723
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.64411
NGRN neugrin, neurite outgrowth associated -2.5982
RFC2 replication factor C (activator 1) 2, 40kDa -2.54457
AQP8 aquaporin 8 -2.22801
CD320 CD320 molecule -2.17143
VSIG4 V-set and immunoglobulin domain containing 4 -2.12777
CCNB2 cyclin B2 -2.10277
FGFR4 fibroblast growth factor receptor 4 -2.09417
TDP2 tyrosyl-DNA phosphodiesterase 2 -2.08816
NEFM neurofilament, medium polypeptide -2.043
SLC26A2 solute carrier family 26 (anion exchanger), member 2 -2.03325
TES testin LIM domain protein -2.01482