CRCGN014_HEPG2_3H:I10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,8-dihydroxy-2-quinolinecarboxylic acid 20.38 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN014_HEPG2_3H:I10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 8.05375
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.46288
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.44023
RPL39L ribosomal protein L39-like 5.05531
NFIL3 nuclear factor, interleukin 3 regulated 4.27787
MAP7 microtubule-associated protein 7 4.16737
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.99708
TIAM1 T-cell lymphoma invasion and metastasis 1 3.8953
MAST2 microtubule associated serine/threonine kinase 2 3.85687
PEX11A peroxisomal biogenesis factor 11 alpha 3.81637
CEP57 centrosomal protein 57kDa 3.48354
GPER1 G protein-coupled estrogen receptor 1 3.38068
LCN2 lipocalin 2 3.2709
CARMIL1 capping protein regulator and myosin 1 linker 1 3.14563
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.11525
JADE2 jade family PHD finger 2 3.02103
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.91728
VGLL4 vestigial-like family member 4 2.61583
NOSIP nitric oxide synthase interacting protein 2.46534
MINDY1 MINDY lysine 48 deubiquitinase 1 2.34599
ANO1 anoctamin 1, calcium activated chloride channel 2.21294
CHEK2 checkpoint kinase 2 2.18011
TNIP1 TNFAIP3 interacting protein 1 2.16522
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.07949
GPATCH8 G patch domain containing 8 2.05766
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.02286

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -5.99754
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.26529
TRIB3 tribbles pseudokinase 3 -4.21331
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.83878
SNX11 sorting nexin 11 -3.62614
CDC20 cell division cycle 20 -3.57818
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.51799
TUBB6 tubulin, beta 6 class V -3.1946
TLR4 toll-like receptor 4 -3.0731
LOC124907782 dual specificity protein phosphatase 22 -3.02525
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.47632
REEP5 receptor accessory protein 5 -2.38554
FAIM Fas apoptotic inhibitory molecule -2.3104
SMNDC1 survival motor neuron domain containing 1 -2.25557
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.14648
OXA1L oxidase (cytochrome c) assembly 1-like -2.11586