CRCGN014_HEPG2_3H:I11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description mitoxantrone 10.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

245 genes differentially expressed following the CRCGN014_HEPG2_3H:I11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.56599
CXCL2 chemokine (C-X-C motif) ligand 2 6.56204
SFTPB surfactant protein B 6.4318
MAP7 microtubule-associated protein 7 5.16535
PNKP polynucleotide kinase 3'-phosphatase 4.97117
GSTZ1 glutathione S-transferase zeta 1 4.96575
STIMATE STIM activating enhancer 4.08342
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 3.70751
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 3.57824
COPS7A COP9 signalosome subunit 7A 3.49253
MYLK myosin light chain kinase 3.38539
SYNE2 spectrin repeat containing, nuclear envelope 2 3.1476
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 3.09691
FPGS folylpolyglutamate synthase 3.08037
ADRB2 adrenoceptor beta 2, surface 3.07903
STK10 serine/threonine kinase 10 3.06498
CORO1A coronin, actin binding protein, 1A 3.05535
LOC122526780 uncharacterized LOC122526780 3.05185
PPARG peroxisome proliferator-activated receptor gamma 2.90879
E2F2 E2F transcription factor 2 2.89484
TSPAN6 tetraspanin 6 2.84973
AXIN1 axin 1 2.83801
VGLL4 vestigial-like family member 4 2.81731
ADAM10 ADAM metallopeptidase domain 10 2.79956
BORCS8 BLOC-1 related complex subunit 8 2.78393
SMIM40 small integral membrane protein 40 2.75241
SKIC8 SKI8 subunit of superkiller complex 2.74705
HEBP1 heme binding protein 1 2.73756
PPP4C protein phosphatase 4, catalytic subunit 2.71691
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.71541
RSU1 Ras suppressor protein 1 2.70487
USP5 ubiquitin specific peptidase 5 (isopeptidase T) 2.69021
ANO10 anoctamin 10 2.6601
CYTH3 cytohesin 3 2.63649
SBDS Shwachman-Bodian-Diamond syndrome 2.62398
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.59264
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 2.58221
CD5L CD5 molecule-like 2.57421
INTS3 integrator complex subunit 3 2.55028
TOP6BL TOP6B like initiator of meiotic double strand breaks 2.54982
PRKCD protein kinase C, delta 2.54123
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 2.5293
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 2.50758
FBXW4 F-box and WD repeat domain containing 4 2.50691
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.50598
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 2.50374
U2AF2 U2 small nuclear RNA auxiliary factor 2 2.50305
CAMKMT calmodulin-lysine N-methyltransferase 2.4845
NEU2 sialidase 2 (cytosolic sialidase) 2.4606
MARCO macrophage receptor with collagenous structure 2.45459
SCRN1 secernin 1 2.43243
LMO7 LIM domain 7 2.42132
NIPSNAP1 nipsnap homolog 1 (C. elegans) 2.41909
UNC13A unc-13 homolog A (C. elegans) 2.41459
FBXO40 F-box protein 40 2.38511
PRCP prolylcarboxypeptidase (angiotensinase C) 2.38413
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 2.37636
CYB561 cytochrome b561 2.37569
SCRN3 secernin 3 2.37423
DYNLT3 dynein, light chain, Tctex-type 3 2.37382
SNX13 sorting nexin 13 2.37296
SIRT3 sirtuin 3 2.36993
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2.36275
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 2.35504
CHMP2A charged multivesicular body protein 2A 2.34947
SNX6 sorting nexin 6 2.33358
ARPC4-TTLL3 ARPC4-TTLL3 readthrough 2.32197
RALB v-ral simian leukemia viral oncogene homolog B 2.32167
NELL1 NEL-like 1 (chicken) 2.31985
CHN1 chimerin 1 2.31561
FIG4 FIG4 phosphoinositide 5-phosphatase 2.30315
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 2.2952
GPR45 G protein-coupled receptor 45 2.2841
MBD5 methyl-CpG binding domain protein 5 2.26524
TSEN2 TSEN2 tRNA splicing endonuclease subunit 2.26292
FABP3 fatty acid binding protein 3, muscle and heart 2.2568
RPGRIP1L RPGRIP1-like 2.25031
RPRD1A regulation of nuclear pre-mRNA domain containing 1A 2.2365
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.23382
FKBP1B FK506 binding protein 1B, 12.6 kDa 2.23263
NUCB2 nucleobindin 2 2.22785
EYA1 EYA transcriptional coactivator and phosphatase 1 2.22489
PRELID3A PRELI domain containing 3A 2.22439
ARL3 ADP-ribosylation factor-like 3 2.22221
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 2.21876
TMEM59 transmembrane protein 59 2.20605
GNG10 guanine nucleotide binding protein (G protein), gamma 10 2.19308
LMAN1 lectin, mannose-binding, 1 2.19001
SYCP2 synaptonemal complex protein 2 2.18397
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.18327
FBXL2 F-box and leucine-rich repeat protein 2 2.17667
HPCA hippocalcin 2.17559
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.17114
ASCC3 activating signal cointegrator 1 complex subunit 3 2.16339
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 2.16112
BAD BCL2-associated agonist of cell death 2.15234
RGS1 regulator of G-protein signaling 1 2.15082
HOXB3 homeobox B3 2.14952
CPLX2 complexin 2 2.14486
KMT5A lysine methyltransferase 5A 2.13824
ACOT9 acyl-CoA thioesterase 9 2.13249
NAPSA napsin A aspartic peptidase 2.13191
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) 2.13178
ZNF226 zinc finger protein 226 2.12861
TIAM1 T-cell lymphoma invasion and metastasis 1 2.12655
SNX24 sorting nexin 24 2.12052
HEMK2 HemK methyltransferase 2, ETF1 glutamine and histone H4 lysine 2.1187
DPY19L4 dpy-19-like 4 (C. elegans) 2.10906
IFT57 intraflagellar transport 57 2.10827
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 2.10728
PXMP2 peroxisomal membrane protein 2, 22kDa 2.10424
ZNF205 zinc finger protein 205 2.10065
VSX1 visual system homeobox 1 2.09927
NLRP2B NLR family pyrin domain containing 2B 2.09687
DPH2 DPH2 homolog (S. cerevisiae) 2.0942
NUDCD3 NudC domain containing 3 2.0864
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.07999
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 2.078
ACADL acyl-CoA dehydrogenase, long chain 2.07693
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 2.07335
ACKR5 atypical chemokine receptor 5 2.07044
ANO1 anoctamin 1, calcium activated chloride channel 2.06657
LCMT1 leucine carboxyl methyltransferase 1 2.0651
RECQL4 RecQ protein-like 4 2.05718
MKS1 Meckel syndrome, type 1 2.05539
APH1B APH1B gamma secretase subunit 2.04783
PSEN2 presenilin 2 2.03922
MAPKAP1 mitogen-activated protein kinase associated protein 1 2.03823
ADGRB3 adhesion G protein-coupled receptor B3 2.03331
RBKS ribokinase 2.02828
MFSD6 major facilitator superfamily domain containing 6 2.02639
NUCB1 nucleobindin 1 2.02627
DCTD dCMP deaminase 2.02592
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.02201
TOMM6 translocase of outer mitochondrial membrane 6 homolog (yeast) 2.01955
NECTIN4 nectin cell adhesion molecule 4 2.01649
ARMCX4 armadillo repeat containing, X-linked 4 2.01343
RNF103-CHMP3 RNF103-CHMP3 readthrough 2.00646
OLA1 Obg-like ATPase 1 2.00423
UNC13B unc-13 homolog B (C. elegans) 2.00345
YAF2 YY1 associated factor 2 2.00241
DERA deoxyribose-phosphate aldolase (putative) 2.00024

decreased expression

Symbol Name Standardized Value
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -10.0
MYC v-myc avian myelocytomatosis viral oncogene homolog -10.0
FASTKD5 FAST kinase domains 5 -9.89119
IER3 immediate early response 3 -8.78324
TRIB1 tribbles pseudokinase 1 -8.16185
RPP38 ribonuclease P/MRP 38kDa subunit -7.34076
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -7.11024
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -6.98288
LDHD lactate dehydrogenase D -6.72755
DDIT4 DNA-damage-inducible transcript 4 -6.43331
RFC2 replication factor C (activator 1) 2, 40kDa -6.21689
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.03224
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.97462
DUSP6 dual specificity phosphatase 6 -5.74835
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.62431
ARID5B AT rich interactive domain 5B (MRF1-like) -5.30999
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -5.23067
KLHL21 kelch-like family member 21 -5.03781
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -4.58969
TBPL1 TBP-like 1 -4.04475
ADO 2-aminoethanethiol (cysteamine) dioxygenase -4.03499
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.94699
KEAP1 kelch-like ECH-associated protein 1 -3.93614
ALAS1 5'-aminolevulinate synthase 1 -3.87941
ZBTB35 zinc finger and BTB domain containing 35 -3.84026
KDM3A lysine (K)-specific demethylase 3A -3.76329
CGRRF1 cell growth regulator with ring finger domain 1 -3.64325
PCNA proliferating cell nuclear antigen -3.56729
FOSL1 FOS-like antigen 1 -3.55784
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -3.43394
NOP56 NOP56 ribonucleoprotein -3.43367
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.32146
SMG8 SMG8 nonsense mediated mRNA decay factor -3.30842
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -3.29017
CCNB1 cyclin B1 -3.14
TXLNA taxilin alpha -3.10488
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.09716
CDK7 cyclin-dependent kinase 7 -3.07439
LAP3 leucine aminopeptidase 3 -3.06487
GCC1 GRIP and coiled-coil domain containing 1 -3.05307
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.02551
TXNRD1 thioredoxin reductase 1 -3.02361
HOXA5 homeobox A5 -3.01125
IER5 immediate early response 5 -2.99086
ZW10 zw10 kinetochore protein -2.9798
DSG2 desmoglein 2 -2.97979
IER2 immediate early response 2 -2.92643
ZMIZ1 zinc finger, MIZ-type containing 1 -2.8629
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.85703
SQSTM1 sequestosome 1 -2.80412
RNF139 ring finger protein 139 -2.76303
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.74448
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing -2.73628
BCL10 B-cell CLL/lymphoma 10 -2.71634
NCK1 NCK adaptor protein 1 -2.64991
CCNB2 cyclin B2 -2.63533
SLC25A46 solute carrier family 25, member 46 -2.61547
UFM1 ubiquitin-fold modifier 1 -2.6109
NRBF2 nuclear receptor binding factor 2 -2.60864
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2 -2.52096
CEBPB CCAAT/enhancer binding protein (C/EBP), beta -2.50148
SLC25A44 solute carrier family 25, member 44 -2.45983
LOC102724023 ES1 protein homolog, mitochondrial -2.45318
BIRC2 baculoviral IAP repeat containing 2 -2.3409
ZNF7 zinc finger protein 7 -2.33602
FEM1C fem-1 homolog c (C. elegans) -2.2847
TRIM13 tripartite motif containing 13 -2.26657
VTA1 vesicle (multivesicular body) trafficking 1 -2.26526
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.26464
GSPT2 G1 to S phase transition 2 -2.25613
LIF leukemia inhibitory factor -2.25058
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) -2.24252
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -2.21764
FGFR4 fibroblast growth factor receptor 4 -2.19875
GDF15 growth differentiation factor 15 -2.18939
PRCC papillary renal cell carcinoma (translocation-associated) -2.18209
CX3CR1 chemokine (C-X3-C motif) receptor 1 -2.17203
MAPK6 mitogen-activated protein kinase 6 -2.16809
RESF1 retroelement silencing factor 1 -2.16285
CLIP2 CAP-GLY domain containing linker protein 2 -2.1577
MIURF mitochondrial elongation factor 1 upstream open reading frame -2.15723
HSPA6 heat shock 70kDa protein 6 (HSP70B') -2.15277
RNF31 ring finger protein 31 -2.15229
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.13479
DUSP5 dual specificity phosphatase 5 -2.13472
RLF rearranged L-myc fusion -2.12524
NFE2L2 nuclear factor, erythroid 2-like 2 -2.11
RNF4 ring finger protein 4 -2.10887
NUP62 nucleoporin 62kDa -2.10723
OGN osteoglycin -2.1072
SCGB1D2 secretoglobin, family 1D, member 2 -2.10392
KLF10 Kruppel-like factor 10 -2.09878
ZNF267 zinc finger protein 267 -2.09565
TOB1 transducer of ERBB2, 1 -2.09407
AKR1C3 aldo-keto reductase family 1, member C3 -2.08153
TRIB3 tribbles pseudokinase 3 -2.07932
RAB9A RAB9A, member RAS oncogene family -2.0695
KLHL9 kelch-like family member 9 -2.05406
TUBB4A tubulin, beta 4A class IVa -2.04323
ADNP activity-dependent neuroprotector homeobox -2.0391
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.02431
TBCC tubulin folding cofactor C -2.01868
RIOK2 RIO kinase 2 -2.00611