CRCGN014_HEPG2_3H:I12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description mitoxantrone 5.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

313 genes differentially expressed following the CRCGN014_HEPG2_3H:I12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 5.57644
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.8969
ANO1 anoctamin 1, calcium activated chloride channel 4.73127
FAIM Fas apoptotic inhibitory molecule 4.6142
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.44833
CCDC85B coiled-coil domain containing 85B 4.41837
GET1 guided entry of tail-anchored proteins factor 1 4.36441
E2F2 E2F transcription factor 2 4.19563
EVL Enah/Vasp-like 4.15497
C2CD2 C2 calcium-dependent domain containing 2 4.15208
PNKP polynucleotide kinase 3'-phosphatase 4.07888
TIMP2 TIMP metallopeptidase inhibitor 2 3.97844
CRTAP cartilage associated protein 3.95369
NOSIP nitric oxide synthase interacting protein 3.79328
NUP133 nucleoporin 133kDa 3.7348
PRCP prolylcarboxypeptidase (angiotensinase C) 3.73122
CETN3 centrin, EF-hand protein, 3 3.66455
CSK c-src tyrosine kinase 3.58905
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.5735
STIMATE STIM activating enhancer 3.55483
DIPK1A divergent protein kinase domain 1A 3.50381
MCOLN1 mucolipin 1 3.45356
PLS1 plastin 1 3.43323
SIDT1 SID1 transmembrane family, member 1 3.36317
PPARG peroxisome proliferator-activated receptor gamma 3.30716
RSU1 Ras suppressor protein 1 3.26857
NTM neurotrimin 3.24845
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.20815
HDGFL3 HDGF like 3 3.1141
CTSL cathepsin L 3.06375
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.04731
MSRA methionine sulfoxide reductase A 3.00791
STAP2 signal transducing adaptor family member 2 2.98784
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.97437
NUCB2 nucleobindin 2 2.95205
FIG4 FIG4 phosphoinositide 5-phosphatase 2.85689
PARP1 poly (ADP-ribose) polymerase 1 2.85013
STUM stum, mechanosensory transduction mediator homolog 2.81523
PEX11A peroxisomal biogenesis factor 11 alpha 2.76644
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 2.755
BHMT2 betaine--homocysteine S-methyltransferase 2 2.74162
COPZ2 coatomer protein complex, subunit zeta 2 2.73227
ACOT9 acyl-CoA thioesterase 9 2.68637
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 2.64803
AP3B2 adaptor-related protein complex 3, beta 2 subunit 2.64523
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 2.6378
SP140L SP140 nuclear body protein-like 2.62691
MAP7 microtubule-associated protein 7 2.62225
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.62162
NIPSNAP1 nipsnap homolog 1 (C. elegans) 2.61863
LAGE3 L antigen family, member 3 2.60546
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 2.59173
CRIPT cysteine-rich PDZ-binding protein 2.59107
SKIC2 SKI2 subunit of superkiller complex 2.58396
PCCB propionyl CoA carboxylase, beta polypeptide 2.58147
SNAP25 synaptosomal-associated protein, 25kDa 2.57783
COTL1 coactosin-like F-actin binding protein 1 2.57119
SLC16A4 solute carrier family 16, member 4 2.56321
ECH1 enoyl CoA hydratase 1, peroxisomal 2.56026
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) 2.54422
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.53832
TMEM176A transmembrane protein 176A 2.53237
CDK6 cyclin-dependent kinase 6 2.52506
SCRN1 secernin 1 2.5109
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.4857
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 2.4816
EPS8L2 EPS8-like 2 2.4619
RIMBP2 RIMS binding protein 2 2.45109
NCAM2 neural cell adhesion molecule 2 2.44991
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 2.44098
VEGFC vascular endothelial growth factor C 2.43293
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.43198
PECR peroxisomal trans-2-enoyl-CoA reductase 2.4242
HOXC10 homeobox C10 2.41693
PRKCH protein kinase C, eta 2.41313
ELP4 elongator acetyltransferase complex subunit 4 2.39488
GHRH growth hormone releasing hormone 2.39291
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.38699
THOC7 THO complex 7 2.38662
HACD3 3-hydroxyacyl-CoA dehydratase 3 2.3806
LLGL2 lethal giant larvae homolog 2 (Drosophila) 2.37549
BZW2 basic leucine zipper and W2 domains 2 2.37135
SNX7 sorting nexin 7 2.36791
RRAS related RAS viral (r-ras) oncogene homolog 2.35277
C5 complement component 5 2.34828
ADGRF1 adhesion G protein-coupled receptor F1 2.34784
TREM1 triggering receptor expressed on myeloid cells 1 2.34168
ACOX1 acyl-CoA oxidase 1, palmitoyl 2.33751
MBOAT2 membrane bound O-acyltransferase domain containing 2 2.33456
VAMP5 vesicle-associated membrane protein 5 2.32301
TAOK3 TAO kinase 3 2.30371
PROS1 protein S (alpha) 2.29886
IFT20 intraflagellar transport 20 2.29547
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.29262
SKIC8 SKI8 subunit of superkiller complex 2.28916
PIGK phosphatidylinositol glycan anchor biosynthesis, class K 2.28773
GOLT1B golgi transport 1B 2.28147
BBOF1 basal body orientation factor 1 2.27962
ANO10 anoctamin 10 2.27147
ADGRE5 adhesion G protein-coupled receptor E5 2.26908
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 2.25705
HPCA hippocalcin 2.25321
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 2.25277
WDR41 WD repeat domain 41 2.24227
DNAH7 dynein, axonemal, heavy chain 7 2.23544
ILK integrin-linked kinase 2.23519
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.23414
PROCR protein C receptor, endothelial 2.23312
FAM149A family with sequence similarity 149, member A 2.23139
HIGD1A HIG1 hypoxia inducible domain family, member 1A 2.23103
MPV17L-BMERB1 MPV17L-BMERB1 readthrough 2.2306
ETFA electron-transfer-flavoprotein, alpha polypeptide 2.22813
PHF21A PHD finger protein 21A 2.21735
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 2.21481
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.21175
INTS3 integrator complex subunit 3 2.18319
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 2.17979
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 2.16593
GID8 GID complex subunit 8 2.16316
STXBP2 syntaxin binding protein 2 2.16257
EML3 echinoderm microtubule associated protein like 3 2.14265
FKBP1B FK506 binding protein 1B, 12.6 kDa 2.14168
PPIE peptidylprolyl isomerase E (cyclophilin E) 2.14048
OXCT1 3-oxoacid CoA transferase 1 2.13385
INTS8 integrator complex subunit 8 2.12981
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 2.12584
OSBPL10 oxysterol binding protein-like 10 2.12388
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.11464
CARMIL1 capping protein regulator and myosin 1 linker 1 2.11228
MRAS muscle RAS oncogene homolog 2.1106
SEC61B Sec61 beta subunit 2.11015
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 2.11012
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 2.10412
HOXC8 homeobox C8 2.10325
SNRPN small nuclear ribonucleoprotein polypeptide N 2.10214
RPL39L ribosomal protein L39-like 2.09794
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.09692
TRPM2 transient receptor potential cation channel, subfamily M, member 2 2.09421
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 2.08146
CRYZ crystallin, zeta (quinone reductase) 2.08022
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 2.06737
INPP5F inositol polyphosphate-5-phosphatase F 2.0644
LYRM1 LYR motif containing 1 2.06121
ISOC2 isochorismatase domain containing 2 2.05077
PREPL prolyl endopeptidase-like 2.04993
LDAH lipid droplet associated hydrolase 2.0408
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 2.03505
TMEM176B transmembrane protein 176B 2.03473
TBCA tubulin folding cofactor A 2.03304
IGFBP3 insulin-like growth factor binding protein 3 2.0311
COPS7B COP9 signalosome subunit 7B 2.03005
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 2.02891
BICDL1 BICD family like cargo adaptor 1 2.02532
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 2.02529
TMEM50A transmembrane protein 50A 2.02198
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 2.02195
ACKR3 atypical chemokine receptor 3 2.0219
ERGIC2 ERGIC and golgi 2 2.02157
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 2.01264
ELOVL6 ELOVL fatty acid elongase 6 2.01198
KIAA0319 KIAA0319 2.01184
TGFB3 transforming growth factor, beta 3 2.01043
RABEPK Rab9 effector protein with kelch motifs 2.00987
PLEKHA6 pleckstrin homology domain containing, family A member 6 2.00667
STAMBP STAM binding protein 2.0061
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 2.00554
PPP4C protein phosphatase 4, catalytic subunit 2.00297
RPIA ribose 5-phosphate isomerase A 2.00164
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 2.00118
FOXO4 forkhead box O4 2.00042

decreased expression

Symbol Name Standardized Value
MYC v-myc avian myelocytomatosis viral oncogene homolog -10.0
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -10.0
FASTKD5 FAST kinase domains 5 -9.94033
IER3 immediate early response 3 -8.51163
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -7.98234
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -7.88448
TRIB1 tribbles pseudokinase 1 -7.45975
CCNB2 cyclin B2 -7.32255
RFC2 replication factor C (activator 1) 2, 40kDa -6.41851
DUSP6 dual specificity phosphatase 6 -6.28531
RPP38 ribonuclease P/MRP 38kDa subunit -6.25481
DDIT4 DNA-damage-inducible transcript 4 -6.18328
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -6.17882
ARID5B AT rich interactive domain 5B (MRF1-like) -5.69569
TRIB3 tribbles pseudokinase 3 -5.65322
CD320 CD320 molecule -5.50671
ZMIZ1 zinc finger, MIZ-type containing 1 -5.29929
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.16701
KLHL21 kelch-like family member 21 -4.97769
ADO 2-aminoethanethiol (cysteamine) dioxygenase -4.77375
CCDC86 coiled-coil domain containing 86 -4.41595
KEAP1 kelch-like ECH-associated protein 1 -4.3688
ZNF586 zinc finger protein 586 -4.36119
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -4.28061
DCK deoxycytidine kinase -4.07985
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.02659
SCAND1 SCAN domain containing 1 -4.02019
OXA1L oxidase (cytochrome c) assembly 1-like -3.91622
RGS2 regulator of G-protein signaling 2 -3.83232
FOSL1 FOS-like antigen 1 -3.83063
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -3.45082
ZBTB35 zinc finger and BTB domain containing 35 -3.37796
TBC1D31 TBC1 domain family, member 31 -3.35447
TXLNA taxilin alpha -3.22294
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma -3.07029
ZW10 zw10 kinetochore protein -3.05829
SLC35F2 solute carrier family 35, member F2 -3.04108
CDC25B cell division cycle 25B -3.03774
ALAS1 5'-aminolevulinate synthase 1 -2.96355
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.96086
SETD5 SET domain containing 5 -2.89368
BYSL bystin-like -2.89205
ABT1 activator of basal transcription 1 -2.88498
TRIM13 tripartite motif containing 13 -2.87196
ANKRD10 ankyrin repeat domain 10 -2.83351
CGRRF1 cell growth regulator with ring finger domain 1 -2.81811
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 -2.74709
NOP2 NOP2 nucleolar protein -2.74421
RBM15 RNA binding motif protein 15 -2.74328
KIF14 kinesin family member 14 -2.6985
HSPA1B heat shock 70kDa protein 1B -2.69658
CCNJ cyclin J -2.69161
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 -2.69071
MGA MGA, MAX dimerization protein -2.67879
CTCF CCCTC-binding factor (zinc finger protein) -2.67373
ZNF146 zinc finger protein 146 -2.67288
ZCCHC2 zinc finger, CCHC domain containing 2 -2.63009
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.62295
PRPF38B pre-mRNA processing factor 38B -2.61606
NIP7 NIP7, nucleolar pre-rRNA processing protein -2.58366
MED17 mediator complex subunit 17 -2.57423
TBPL1 TBP-like 1 -2.57209
ZNF574 zinc finger protein 574 -2.56755
CEBPB CCAAT/enhancer binding protein (C/EBP), beta -2.52717
RFWD3 ring finger and WD repeat domain 3 -2.52249
RNF139 ring finger protein 139 -2.52176
FBXO5 F-box protein 5 -2.52174
RNF31 ring finger protein 31 -2.51475
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.49958
CDK7 cyclin-dependent kinase 7 -2.49102
TBCB tubulin folding cofactor B -2.49102
NCK1 NCK adaptor protein 1 -2.48562
RIOX1 ribosomal oxygenase 1 -2.48354
ZNF212 zinc finger protein 212 -2.47972
MAT2A methionine adenosyltransferase II, alpha -2.45586
GRWD1 glutamate-rich WD repeat containing 1 -2.43973
AAR2 AAR2 splicing factor homolog (S. cerevisiae) -2.4382
NOP16 NOP16 nucleolar protein -2.3948
NFE2L2 nuclear factor, erythroid 2-like 2 -2.38341
IER2 immediate early response 2 -2.37655
NUP62 nucleoporin 62kDa -2.36828
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.36183
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 -2.34766
FAM193A family with sequence similarity 193, member A -2.33716
CAPNS1 calpain, small subunit 1 -2.33309
SPTSSA serine palmitoyltransferase, small subunit A -2.32166
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -2.31253
TXNDC9 thioredoxin domain containing 9 -2.3071
NOP56 NOP56 ribonucleoprotein -2.29924
AKAP17A A kinase (PRKA) anchor protein 17A -2.29878
TLCD3A TLC domain containing 3A -2.28898
NKRF NFKB repressing factor -2.28007
VCPKMT valosin containing protein lysine (K) methyltransferase -2.27929
SEC24B SEC24 family member B -2.27159
POM121C POM121 transmembrane nucleoporin C -2.26386
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa -2.2624
LIN37 lin-37 DREAM MuvB core complex component -2.259
EFNB1 ephrin-B1 -2.24695
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A -2.24557
TMEM147 transmembrane protein 147 -2.23886
PDCD5 programmed cell death 5 -2.22667
VDAC1 voltage-dependent anion channel 1 -2.21766
BAZ1A bromodomain adjacent to zinc finger domain, 1A -2.21695
ISOC1 isochorismatase domain containing 1 -2.21458
SAV1 salvador family WW domain containing protein 1 -2.21033
FBXL12 F-box and leucine-rich repeat protein 12 -2.20841
MSH6 mutS homolog 6 -2.18659
LOC124907782 dual specificity protein phosphatase 22 -2.17228
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 -2.17204
ND5 NADH dehydrogenase subunit 5 -2.16528
BIRC2 baculoviral IAP repeat containing 2 -2.16347
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.15695
TBCC tubulin folding cofactor C -2.14927
SLC25A46 solute carrier family 25, member 46 -2.14884
CPTP ceramide-1-phosphate transfer protein -2.14859
SPRY2 sprouty homolog 2 (Drosophila) -2.14267
ELF2 E74-like factor 2 (ets domain transcription factor) -2.12879
ZNF318 zinc finger protein 318 -2.12218
SDHAF1 succinate dehydrogenase complex assembly factor 1 -2.11302
ZNF281 zinc finger protein 281 -2.11165
BRD1 bromodomain containing 1 -2.10903
THAP12 THAP domain containing 12 -2.1054
MED9 mediator complex subunit 9 -2.10172
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.09724
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit -2.07984
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -2.06153
KMT5B lysine methyltransferase 5B -2.05977
E2F8 E2F transcription factor 8 -2.05867
PARP2 poly (ADP-ribose) polymerase 2 -2.05307
TMEM11 transmembrane protein 11 -2.05147
SCGB2A1 secretoglobin, family 2A, member 1 -2.0485
STRN3 striatin, calmodulin binding protein 3 -2.04428
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -2.04383
LRFN3 leucine rich repeat and fibronectin type III domain containing 3 -2.04348
POLR1G RNA polymerase I subunit G -2.04032
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) -2.03616
TBX3 T-box 3 -2.03609
USPL1 ubiquitin specific peptidase like 1 -2.03371
DENND10 DENN domain containing 10 -2.01443
SQSTM1 sequestosome 1 -2.01426
SNIP1 Smad nuclear interacting protein 1 -2.00907
SMG8 SMG8 nonsense mediated mRNA decay factor -2.00903
ZNF140 zinc finger protein 140 -2.00076