CRCGN014_HEPG2_3H:I13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description felbamate 20.15 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

116 genes differentially expressed following the CRCGN014_HEPG2_3H:I13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 8.51053
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.82482
MAP7 microtubule-associated protein 7 6.0777
AMDHD2 amidohydrolase domain containing 2 5.25014
UBQLN2 ubiquilin 2 4.55588
CXCL2 chemokine (C-X-C motif) ligand 2 4.38339
CBR3 carbonyl reductase 3 4.37064
INTS3 integrator complex subunit 3 4.2483
ADRB2 adrenoceptor beta 2, surface 4.24046
INSIG1 insulin induced gene 1 4.17024
MAMLD1 mastermind-like domain containing 1 4.16759
STIMATE STIM activating enhancer 3.8424
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 3.82249
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 3.7958
TIAM1 T-cell lymphoma invasion and metastasis 1 3.73353
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.68599
FZD7 frizzled class receptor 7 3.63686
OXCT1 3-oxoacid CoA transferase 1 3.61309
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.4738
ADGRE5 adhesion G protein-coupled receptor E5 3.31099
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.28511
ABHD6 abhydrolase domain containing 6 3.21467
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.18397
CYCS cytochrome c, somatic 2.94032
GADD45A growth arrest and DNA-damage-inducible, alpha 2.93497
CCNF cyclin F 2.83904
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.8192
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.72852
LCN2 lipocalin 2 2.67018
SLC25A46 solute carrier family 25, member 46 2.62311
STAP2 signal transducing adaptor family member 2 2.6104
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.57527
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.53086
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.40863
PCDHB11 protocadherin beta 11 2.39634
PRKCD protein kinase C, delta 2.38441
PPARG peroxisome proliferator-activated receptor gamma 2.30689
COQ8A coenzyme Q8A 2.30627
GPATCH8 G patch domain containing 8 2.29162
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.28082
ZC3HAV1 zinc finger CCCH-type, antiviral 1 2.25251
HLA-DMA major histocompatibility complex, class II, DM alpha 2.24458
SIRAL2 SIR2 antiphage like 2 2.24022
MYLK myosin light chain kinase 2.22889
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.22445
MFGE8 milk fat globule-EGF factor 8 protein 2.21842
UBE2A ubiquitin-conjugating enzyme E2A 2.21201
MAST2 microtubule associated serine/threonine kinase 2 2.18213
EVL Enah/Vasp-like 2.17158
CARMIL1 capping protein regulator and myosin 1 linker 1 2.14777
IGF1 insulin-like growth factor 1 (somatomedin C) 2.14282
KIFBP kinesin family binding protein 2.14269
PARP1 poly (ADP-ribose) polymerase 1 2.13684
GSTM2 glutathione S-transferase mu 2 (muscle) 2.1351
NID2 nidogen 2 (osteonidogen) 2.13105
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.11607
KLHL21 kelch-like family member 21 2.10184
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.09379
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.08837
HBZ hemoglobin, zeta 2.0778
LIME1 Lck interacting transmembrane adaptor 1 2.06445
STXBP1 syntaxin binding protein 1 2.04092
PLS1 plastin 1 2.03946
C15ORF38-AP3S2 C15orf38-AP3S2 readthrough 2.03101
FBLN5 fibulin 5 2.02201
TSPYL1 TSPY-like 1 2.01984
CD180 CD180 molecule 2.00695

decreased expression

Symbol Name Standardized Value
TLCD3A TLC domain containing 3A -6.72626
PCNA proliferating cell nuclear antigen -6.14362
ADI1 acireductone dioxygenase 1 -5.3836
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.95402
VAT1 vesicle amine transport 1 -4.53347
KDM3A lysine (K)-specific demethylase 3A -4.18928
SPAG4 sperm associated antigen 4 -4.1415
TBC1D31 TBC1 domain family, member 31 -3.93899
SLC35F2 solute carrier family 35, member F2 -3.7775
TLR4 toll-like receptor 4 -3.62274
CCDC86 coiled-coil domain containing 86 -3.61354
CTSD cathepsin D -3.54713
RFC2 replication factor C (activator 1) 2, 40kDa -3.44485
ALDOC aldolase C, fructose-bisphosphate -2.81166
AKAP8 A kinase (PRKA) anchor protein 8 -2.72675
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.71252
NRIP1 nuclear receptor interacting protein 1 -2.66313
SNX11 sorting nexin 11 -2.5654
LORICRIN loricrin cornified envelope precursor protein -2.45943
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.45507
ACLY ATP citrate lyase -2.42126
TCTN1 tectonic family member 1 -2.41275
TMEM45A transmembrane protein 45A -2.40651
DERA deoxyribose-phosphate aldolase (putative) -2.38657
MRPL49 mitochondrial ribosomal protein L49 -2.30261
PECR peroxisomal trans-2-enoyl-CoA reductase -2.2552
DYNLT1 dynein, light chain, Tctex-type 1 -2.22248
WDR7 WD repeat domain 7 -2.19697
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.17872
FAM32A family with sequence similarity 32, member A -2.16876
ELOVL4 ELOVL fatty acid elongase 4 -2.14128
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) -2.13693
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.13504
TMSB4X thymosin beta 4, X-linked -2.12936
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing -2.12815
FOXD1 forkhead box D1 -2.12246
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.116
NKIRAS2 NFKB inhibitor interacting Ras-like 2 -2.09377
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase -2.08329
LOC124907782 dual specificity protein phosphatase 22 -2.07149
LIPF lipase, gastric -2.06937
WDR45B WD repeat domain 45B -2.06282
CDHR1 cadherin-related family member 1 -2.03768
FOS FBJ murine osteosarcoma viral oncogene homolog -2.03326
MAP3K7CL MAP3K7 C-terminal like -2.03032
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.02968
SLC38A12 solute carrier family 38 member 12 -2.01235
SORCS3 sortilin-related VPS10 domain containing receptor 3 -2.00068
PUM3 pumilio RNA binding family member 3 -2.00007