CRCGN014_HEPG2_3H:I15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description monoethylhexylphthalate 40.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN014_HEPG2_3H:I15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ANO1 anoctamin 1, calcium activated chloride channel 4.51241
CHMP6 charged multivesicular body protein 6 4.38605
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.12715
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.06984
DIPK1A divergent protein kinase domain 1A 3.91838
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.7372
EPHB2 EPH receptor B2 3.66688
FZD7 frizzled class receptor 7 3.36862
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.31676
C2CD2 C2 calcium-dependent domain containing 2 3.16413
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.03643
STK10 serine/threonine kinase 10 2.86436
SIRT3 sirtuin 3 2.72788
PEX11A peroxisomal biogenesis factor 11 alpha 2.69152
VGLL4 vestigial-like family member 4 2.64262
PFKL phosphofructokinase, liver 2.6205
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.61035
BZW2 basic leucine zipper and W2 domains 2 2.5735
TIAM1 T-cell lymphoma invasion and metastasis 1 2.4543
TBC1D10C TBC1 domain family, member 10C 2.3717
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.27986
CGRRF1 cell growth regulator with ring finger domain 1 2.27039
TREM1 triggering receptor expressed on myeloid cells 1 2.27009
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.20182
SLC12A8 solute carrier family 12, member 8 2.17214
KLHL9 kelch-like family member 9 2.16639
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.09922
STIMATE STIM activating enhancer 2.04956

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -7.26859
ITFG1 integrin alpha FG-GAP repeat containing 1 -6.34204
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.27875
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.16231
PLK1 polo-like kinase 1 -3.92608
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.45633
LDHD lactate dehydrogenase D -3.33765
TRIB3 tribbles pseudokinase 3 -3.13416
THAP11 THAP domain containing 11 -2.60501
OXA1L oxidase (cytochrome c) assembly 1-like -2.53178
TUBB6 tubulin, beta 6 class V -2.42526
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.41233
DNM1L dynamin 1-like -2.39691
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha -2.09678
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.00225