CRCGN014_HEPG2_3H:I16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-(9h-fluoren-2-yl)-2,2,2-trifluoroacetamide 20.2 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

97 genes differentially expressed following the CRCGN014_HEPG2_3H:I16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.41927
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 6.38009
STK10 serine/threonine kinase 10 5.85248
JADE2 jade family PHD finger 2 5.4111
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.12497
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.73591
CCNF cyclin F 3.63313
CGRRF1 cell growth regulator with ring finger domain 1 3.56678
ADGRE5 adhesion G protein-coupled receptor E5 3.54744
ANO1 anoctamin 1, calcium activated chloride channel 3.49744
FOSL1 FOS-like antigen 1 3.15315
C2CD2 C2 calcium-dependent domain containing 2 3.13128
CXCL2 chemokine (C-X-C motif) ligand 2 3.06261
STIMATE STIM activating enhancer 3.04025
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.9906
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.98465
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.95671
BACE2 beta-site APP-cleaving enzyme 2 2.94669
ADRB2 adrenoceptor beta 2, surface 2.81183
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.77864
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.75986
NOSIP nitric oxide synthase interacting protein 2.69773
CBR3 carbonyl reductase 3 2.61268
HYOU1 hypoxia up-regulated 1 2.4861
CCDC86 coiled-coil domain containing 86 2.47919
SBNO1 strawberry notch homolog 1 (Drosophila) 2.44211
CYCS cytochrome c, somatic 2.38389
EVL Enah/Vasp-like 2.28249
FLT3 fms-related tyrosine kinase 3 2.24494
NECTIN2 nectin cell adhesion molecule 2 2.20463
SHB Src homology 2 domain containing adaptor protein B 2.18936
CHMP6 charged multivesicular body protein 6 2.13525
HLA-DRA major histocompatibility complex, class II, DR alpha 2.13155
PRPF38B pre-mRNA processing factor 38B 2.10315
BANP BTG3 associated nuclear protein 2.07129
ANAPC10 anaphase promoting complex subunit 10 2.05722
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.0451

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -10.0
PCNA proliferating cell nuclear antigen -6.15085
DNM1L dynamin 1-like -6.00514
OXA1L oxidase (cytochrome c) assembly 1-like -5.17492
TM9SF3 transmembrane 9 superfamily member 3 -4.12468
PUF60 poly-U binding splicing factor 60KDa -3.38846
NLRP2B NLR family pyrin domain containing 2B -3.29422
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.2664
EDN1 endothelin 1 -3.26561
MRPS2 mitochondrial ribosomal protein S2 -3.05577
CTSD cathepsin D -3.00069
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.99428
RAI14 retinoic acid induced 14 -2.97878
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.93596
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.89413
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.80906
KCNIP2 Kv channel interacting protein 2 -2.65671
MTA1 metastasis associated 1 -2.52914
CHMP4B charged multivesicular body protein 4B -2.51362
ELAC2 elaC ribonuclease Z 2 -2.50482
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) -2.47732
ZMIZ1 zinc finger, MIZ-type containing 1 -2.47183
VAT1 vesicle amine transport 1 -2.44068
NEK11 NIMA-related kinase 11 -2.37959
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) -2.3559
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.3478
NCF4 neutrophil cytosolic factor 4, 40kDa -2.32706
TCEAL4 transcription elongation factor A (SII)-like 4 -2.305
PSRC1 proline/serine-rich coiled-coil 1 -2.29857
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 -2.29139
ITGB1BP1 integrin beta 1 binding protein 1 -2.22878
HSF1 heat shock transcription factor 1 -2.20321
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 -2.20135
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 -2.19537
FNTA farnesyltransferase, CAAX box, alpha -2.1755
IL21R interleukin 21 receptor -2.13449
BEST2 bestrophin 2 -2.13062
NTF3 neurotrophin 3 -2.12899
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 -2.1231
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -2.12083
PTPN7 protein tyrosine phosphatase, non-receptor type 7 -2.11257
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 -2.10535
ZBED2 zinc finger, BED-type containing 2 -2.09489
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) -2.08937
BNC1 basonuclin 1 -2.0821
SNX11 sorting nexin 11 -2.07741
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -2.06836
RASSF9 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 -2.06546
CD1C CD1c molecule -2.06221
LMO3 LIM domain only 3 (rhombotin-like 2) -2.05465
WNT6 wingless-type MMTV integration site family, member 6 -2.04778
LPAR3 lysophosphatidic acid receptor 3 -2.04647
GRAPL GRB2-related adaptor protein-like -2.04511
GREM2 gremlin 2, DAN family BMP antagonist -2.0434
KLK5 kallikrein-related peptidase 5 -2.03223
OR5I1 olfactory receptor, family 5, subfamily I, member 1 -2.02963
MMP2 matrix metallopeptidase 2 -2.02567
BICD1 bicaudal D homolog 1 (Drosophila) -2.02166
HPCA hippocalcin -2.01234
KLF13 Kruppel-like factor 13 -2.00607