CRCGN014_HEPG2_3H:I17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-methyl-4-oxo-3-(2-propynyl)-2-cyclopenten-1-yl 2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylate 21.18 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

100 genes differentially expressed following the CRCGN014_HEPG2_3H:I17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DDIT4 DNA-damage-inducible transcript 4 10.0
HSPA1A heat shock 70kDa protein 1A 10.0
HMOX1 heme oxygenase 1 9.68923
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.84684
BAG3 BCL2-associated athanogene 3 6.04535
KLHL21 kelch-like family member 21 5.78677
ABHD4 abhydrolase domain containing 4 5.77092
MAP7 microtubule-associated protein 7 5.41412
TRIB3 tribbles pseudokinase 3 4.85052
TXNRD1 thioredoxin reductase 1 4.51749
HSPA1B heat shock 70kDa protein 1B 4.22272
CCP110 centriolar coiled coil protein 110kDa 3.99778
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 3.85554
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.77011
GPATCH8 G patch domain containing 8 3.76677
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 3.59294
BACE2 beta-site APP-cleaving enzyme 2 3.50813
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.4498
LPAR2 lysophosphatidic acid receptor 2 3.33826
FOSL1 FOS-like antigen 1 3.17022
SQSTM1 sequestosome 1 3.13347
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.09552
PRKCH protein kinase C, eta 3.09043
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.01074
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.86641
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.8395
CSK c-src tyrosine kinase 2.80598
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.79555
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.76001
ARCN1 archain 1 2.73229
CNPY3 canopy FGF signaling regulator 3 2.67347
NOSIP nitric oxide synthase interacting protein 2.65576
GCLM glutamate-cysteine ligase, modifier subunit 2.63091
FKBP14 FK506 binding protein 14, 22 kDa 2.61872
PCDHB16 protocadherin beta 16 2.60203
CYCS cytochrome c, somatic 2.53202
DIPK1A divergent protein kinase domain 1A 2.51616
HSPA6 heat shock 70kDa protein 6 (HSP70B') 2.51024
RXYLT1 ribitol xylosyltransferase 1 2.4591
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.43696
LCN2 lipocalin 2 2.38867
SNX19 sorting nexin 19 2.28549
BLMH bleomycin hydrolase 2.26456
EGF epidermal growth factor 2.24243
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.22525
ZW10 zw10 kinetochore protein 2.22399
TRIM16 tripartite motif containing 16 2.21055
MAN2B2 mannosidase, alpha, class 2B, member 2 2.20039
AARS1 alanyl-tRNA synthetase 1 2.18992
ZNF862 zinc finger protein 862 2.17698
ANKRD10 ankyrin repeat domain 10 2.16977
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.16473
MLF1 myeloid leukemia factor 1 2.16198
TREM1 triggering receptor expressed on myeloid cells 1 2.16054
ZDHHC18 zinc finger, DHHC-type containing 18 2.14544
PPIE peptidylprolyl isomerase E (cyclophilin E) 2.1204
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.02181
HSPA1L heat shock 70kDa protein 1-like 2.02091
SYNE2 spectrin repeat containing, nuclear envelope 2 2.00279
NAIP NLR family, apoptosis inhibitory protein 2.00144

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.81302
PSRC1 proline/serine-rich coiled-coil 1 -5.63748
OXA1L oxidase (cytochrome c) assembly 1-like -5.24354
CCNB2 cyclin B2 -3.61758
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.5754
GTPBP8 GTP-binding protein 8 (putative) -3.27609
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.08156
NGRN neugrin, neurite outgrowth associated -2.94669
AURKB aurora kinase B -2.94081
EDN1 endothelin 1 -2.92343
CDC20 cell division cycle 20 -2.90564
TXNDC9 thioredoxin domain containing 9 -2.84371
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.71193
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.68192
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.66056
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.51957
CHMP4B charged multivesicular body protein 4B -2.50222
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.50219
ZNF586 zinc finger protein 586 -2.46817
TM9SF3 transmembrane 9 superfamily member 3 -2.46001
ZMIZ1 zinc finger, MIZ-type containing 1 -2.38815
KDM3A lysine (K)-specific demethylase 3A -2.33916
ISOC1 isochorismatase domain containing 1 -2.31038
MRPL35 mitochondrial ribosomal protein L35 -2.24908
GRWD1 glutamate-rich WD repeat containing 1 -2.24667
THAP11 THAP domain containing 11 -2.20403
LOC124907782 dual specificity protein phosphatase 22 -2.20254
EIF5 eukaryotic translation initiation factor 5 -2.19067
NHEJ1 nonhomologous end-joining factor 1 -2.18188
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa -2.17869
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.15013
GMNN geminin, DNA replication inhibitor -2.13554
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 -2.10916
COPS7B COP9 signalosome subunit 7B -2.09543
MAPK13 mitogen-activated protein kinase 13 -2.08125
VPREB3 pre-B lymphocyte 3 -2.06087
HMG20B high mobility group 20B -2.05588
DPYS dihydropyrimidinase -2.02635
FCHSD2 FCH and double SH3 domains 2 -2.02605
HPX hemopexin -2.007