CRCGN014_HEPG2_3H:I19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dimethylformamide 42.6 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

349 genes differentially expressed following the CRCGN014_HEPG2_3H:I19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PEX11A peroxisomal biogenesis factor 11 alpha 8.08467
CYCS cytochrome c, somatic 7.0239
MAP7 microtubule-associated protein 7 6.63812
GPER1 G protein-coupled estrogen receptor 1 6.04152
E2F2 E2F transcription factor 2 5.96335
RPL39L ribosomal protein L39-like 5.7677
ADGRE5 adhesion G protein-coupled receptor E5 5.30655
KLHL21 kelch-like family member 21 5.19115
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.02505
ADRB2 adrenoceptor beta 2, surface 5.0
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.8442
MYLK myosin light chain kinase 4.48195
FAM20B family with sequence similarity 20, member B 4.45977
CRK v-crk avian sarcoma virus CT10 oncogene homolog 4.45278
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.24165
GSTZ1 glutathione S-transferase zeta 1 4.21465
VGLL4 vestigial-like family member 4 3.77923
HPRT1 hypoxanthine phosphoribosyltransferase 1 3.7298
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 3.60715
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.5773
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.5601
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.38705
MATN2 matrilin 2 3.322
MAMLD1 mastermind-like domain containing 1 3.30995
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.2791
PRKCH protein kinase C, eta 3.24482
NENF neudesin neurotrophic factor 3.23435
SELE selectin E 3.124
SLC39A4 solute carrier family 39 (zinc transporter), member 4 3.10125
CCDC92 coiled-coil domain containing 92 3.0343
DENND10 DENN domain containing 10 3.01855
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 3.00075
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.98555
DENND5B DENN/MADD domain containing 5B 2.9615
DRD4 dopamine receptor D4 2.959
QPCTL glutaminyl-peptide cyclotransferase-like 2.95365
SLC25A46 solute carrier family 25, member 46 2.9405
SYTL2 synaptotagmin-like 2 2.931
LGALS1 lectin, galactoside-binding, soluble, 1 2.89045
NLRP4 NLR family, pyrin domain containing 4 2.8756
PDZRN3 PDZ domain containing ring finger 3 2.87005
HSPB2 heat shock 27kDa protein 2 2.86115
DIPK1A divergent protein kinase domain 1A 2.85807
CCL23 chemokine (C-C motif) ligand 23 2.84752
COL16A1 collagen, type XVI, alpha 1 2.8421
SEMG2 semenogelin II 2.83145
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 2.7952
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 2.78565
EVL Enah/Vasp-like 2.78455
GRTP1 growth hormone regulated TBC protein 1 2.78345
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 2.77725
GRK4 G protein-coupled receptor kinase 4 2.76467
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 2.7477
PLS1 plastin 1 2.73765
CBR1 carbonyl reductase 1 2.7354
TUBAL3 tubulin, alpha-like 3 2.6947
IGF1R insulin-like growth factor 1 receptor 2.6679
SATB1 SATB homeobox 1 2.641
BTG1 B-cell translocation gene 1, anti-proliferative 2.63452
ANKRD40CL ANKRD40 C-terminal like 2.62365
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 2.6208
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 2.6163
RAB32 RAB32, member RAS oncogene family 2.6149
FBXO17 F-box protein 17 2.61475
H2AP H2A.P histone 2.5764
ITGA7 integrin, alpha 7 2.57293
PPP4R4 protein phosphatase 4, regulatory subunit 4 2.57193
OSR2 odd-skipped related transciption factor 2 2.56695
FOXD2 forkhead box D2 2.5439
PYY peptide YY 2.53065
CDC20 cell division cycle 20 2.52335
WNT1 wingless-type MMTV integration site family, member 1 2.50795
TM4SF20 transmembrane 4 L six family member 20 2.5057
CLCN2 chloride channel, voltage-sensitive 2 2.503
OGN osteoglycin 2.5009
BBIP1 BBSome interacting protein 1 2.49363
ZG16 zymogen granule protein 16 2.4864
RAMP3 receptor (G protein-coupled) activity modifying protein 3 2.48415
DUSP21 dual specificity phosphatase 21 2.48225
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.4821
LGSN lengsin, lens protein with glutamine synthetase domain 2.4729
NT5M 5',3'-nucleotidase, mitochondrial 2.47235
SLC26A3 solute carrier family 26 (anion exchanger), member 3 2.45145
HHLA2 HERV-H LTR-associating 2 2.4502
RNASE12 ribonuclease, RNase A family, 12 (non-active) 2.44735
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.44535
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 2.44065
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 2.43885
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 2.4346
STK10 serine/threonine kinase 10 2.43173
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.4202
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 2.42015
ATP7B ATPase, Cu++ transporting, beta polypeptide 2.41775
ZNF556 zinc finger protein 556 2.4106
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.4003
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 2.3994
FGF8 fibroblast growth factor 8 (androgen-induced) 2.3968
HOXB8 homeobox B8 2.3932
SSH1 slingshot protein phosphatase 1 2.3914
LDHB lactate dehydrogenase B 2.39025
FAM117A family with sequence similarity 117, member A 2.388
MLANA melan-A 2.38275
CCNF cyclin F 2.38225
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 2.38185
FCHO1 FCH domain only 1 2.37675
FLCN folliculin 2.3743
ADAM18 ADAM metallopeptidase domain 18 2.3643
SSX5 synovial sarcoma, X breakpoint 5 2.3608
PMEL premelanosome protein 2.35938
LOC124900193 uncharacterized LOC124900193 2.3582
ADRA2A adrenoceptor alpha 2A 2.35705
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.35605
PTTG1 pituitary tumor-transforming 1 2.3468
SRPK3 SRSF protein kinase 3 2.3465
ARMCX1 armadillo repeat containing, X-linked 1 2.3442
CD7 CD7 molecule 2.34352
BMP3 bone morphogenetic protein 3 2.3434
SEMG1 semenogelin I 2.33905
FHL5 four and a half LIM domains 5 2.3354
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) 2.3142
TULP2 tubby like protein 2 2.3067
FOXRED2 FAD-dependent oxidoreductase domain containing 2 2.3008
ALCAM activated leukocyte cell adhesion molecule 2.3003
ZIC4 Zic family member 4 2.2984
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 2.29195
MROH7 maestro heat-like repeat family member 7 2.28935
TAC4 tachykinin 4 (hemokinin) 2.2893
MEOX1 mesenchyme homeobox 1 2.28785
GOLGA8N golgin A8 family, member N 2.28675
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.27815
CEP97 centrosomal protein 97kDa 2.26475
RMDN1 regulator of microtubule dynamics 1 2.2636
GUCA2B guanylate cyclase activator 2B (uroguanylin) 2.2633
KIF14 kinesin family member 14 2.2511
KATNA1 katanin p60 (ATPase containing) subunit A 1 2.2485
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) 2.24705
SLC44A1 solute carrier family 44 (choline transporter), member 1 2.24295
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 2.2411
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 2.2349
SHH sonic hedgehog 2.2341
ARC activity-regulated cytoskeleton-associated protein 2.23215
PGAM4 phosphoglycerate mutase family member 4 2.22715
LRRC8E leucine rich repeat containing 8 family, member E 2.2244
SAP30L SAP30-like 2.2198
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.2163
SH3TC2 SH3 domain and tetratricopeptide repeats 2 2.21605
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 2.2118
MMP1 matrix metallopeptidase 1 2.2096
GFI1 growth factor independent 1 transcription repressor 2.19925
ISG15 ISG15 ubiquitin-like modifier 2.19895
BUB1B-PAK6 BUB1B-PAK6 readthrough 2.19288
GPR25 G protein-coupled receptor 25 2.1921
CNRIP1 cannabinoid receptor interacting protein 1 2.1841
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 2.17965
CHRNE cholinergic receptor, nicotinic, epsilon (muscle) 2.17555
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 2.17195
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) 2.16345
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 2.1628
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) 2.1571
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa 2.15272
DUSP28 dual specificity phosphatase 28 2.151
PRND prion protein 2 (dublet) 2.15015
MTDH metadherin 2.14643
MMP23B matrix metallopeptidase 23B 2.14435
POU6F2 POU class 6 homeobox 2 2.143
POU3F3 POU class 3 homeobox 3 2.14255
NDOR1 NADPH dependent diflavin oxidoreductase 1 2.1384
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 2.13785
VIPR2 vasoactive intestinal peptide receptor 2 2.1374
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 2.13705
COL19A1 collagen, type XIX, alpha 1 2.13345
MYO1A myosin IA 2.1316
S100G S100 calcium binding protein G 2.13115
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 2.13059
PHOX2A paired-like homeobox 2a 2.12845
EXOSC4 exosome component 4 2.12673
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.12595
OAT ornithine aminotransferase 2.1247
GJA4 gap junction protein, alpha 4, 37kDa 2.1217
DOT1L DOT1-like histone H3K79 methyltransferase 2.1213
NPIPA6 nuclear pore complex interacting protein family, member A6 2.1187
KIF3A kinesin family member 3A 2.1169
TSKS testis-specific serine kinase substrate 2.1153
RORB RAR-related orphan receptor B 2.11
SLC17A4 solute carrier family 17, member 4 2.1086
RFX1 regulatory factor X, 1 (influences HLA class II expression) 2.10308
PLSCR2 phospholipid scramblase 2 2.10285
FBXO24 F-box protein 24 2.1017
MISP mitotic spindle positioning 2.10165
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.1015
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 2.10015
GAS1 growth arrest-specific 1 2.09807
LDHAL6B lactate dehydrogenase A-like 6B 2.09645
AHCY adenosylhomocysteinase 2.0935
TGIF2 TGFB-induced factor homeobox 2 2.0914
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.09105
CPPED1 calcineurin-like phosphoesterase domain containing 1 2.0909
ADAMTSL2 ADAMTS-like 2 2.09015
CPAMD8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8 2.0871
RERGL RERG/RAS-like 2.0869
AEBP1 AE binding protein 1 2.08115
CCL15 chemokine (C-C motif) ligand 15 2.0791
HDAC9 histone deacetylase 9 2.07805
ONECUT2 one cut homeobox 2 2.0738
KIFBP kinesin family binding protein 2.0696
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2 2.069
ARID5B AT rich interactive domain 5B (MRF1-like) 2.06795
PDE11A phosphodiesterase 11A 2.06245
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 2.06135
COL4A6 collagen, type IV, alpha 6 2.05617
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 2.0548
CCNH cyclin H 2.0545
SLIRP SRA stem-loop interacting RNA binding protein 2.0539
BICRAL BICRA like chromatin remodeling complex associated protein 2.0512
AKT2 v-akt murine thymoma viral oncogene homolog 2 2.05
S1PR5 sphingosine-1-phosphate receptor 5 2.04895
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit 2.0486
INSL5 insulin-like 5 2.04725
CCNA1 cyclin A1 2.04075
PCYOX1 prenylcysteine oxidase 1 2.03675
MYEF2 myelin expression factor 2 2.0346
ELAVL1 ELAV like RNA binding protein 1 2.0328
ZNF280B zinc finger protein 280B 2.0278
AP2A2 adaptor-related protein complex 2, alpha 2 subunit 2.02778
METTL16 methyltransferase like 16 2.0271
ASB9 ankyrin repeat and SOCS box containing 9 2.0261
RPL36AL ribosomal protein L36a-like 2.02585
AQP8 aquaporin 8 2.02435
PRM2 protamine 2 2.0239
MCUR1 mitochondrial calcium uniporter regulator 1 2.0207
BEST2 bestrophin 2 2.0197
ACE2 angiotensin I converting enzyme 2 2.0194
MORC1 MORC family CW-type zinc finger 1 2.01815
DVL2 dishevelled segment polarity protein 2 2.01657
MEPCE methylphosphate capping enzyme 2.0154
SOCS4 suppressor of cytokine signaling 4 2.01455
PRLH prolactin releasing hormone 2.0115
PLXDC1 plexin domain containing 1 2.01117
TGM4 transglutaminase 4 2.01097
LCT lactase 2.0073
ADRA1B adrenoceptor alpha 1B 2.00445
CCDC70 coiled-coil domain containing 70 2.001

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -7.4766
MRPS2 mitochondrial ribosomal protein S2 -5.34505
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.1106
PCNA proliferating cell nuclear antigen -4.8472
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.78315
SLC35F2 solute carrier family 35, member F2 -4.7306
ZMIZ1 zinc finger, MIZ-type containing 1 -4.71475
OXA1L oxidase (cytochrome c) assembly 1-like -4.70565
TSEN2 TSEN2 tRNA splicing endonuclease subunit -4.6697
FASTKD5 FAST kinase domains 5 -4.5687
RFC2 replication factor C (activator 1) 2, 40kDa -4.4958
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.44635
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.36675
LOC124907782 dual specificity protein phosphatase 22 -4.13435
TLCD3A TLC domain containing 3A -3.9812
FAIM Fas apoptotic inhibitory molecule -3.87465
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.64785
MAPK13 mitogen-activated protein kinase 13 -3.6372
DYNLT3 dynein, light chain, Tctex-type 3 -3.2155
NRIP1 nuclear receptor interacting protein 1 -3.136
CCDC86 coiled-coil domain containing 86 -3.122
ZNF761 zinc finger protein 761 -3.07135
UNC13B unc-13 homolog B (C. elegans) -3.0643
TLR4 toll-like receptor 4 -3.058
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.02355
FANCG Fanconi anemia, complementation group G -2.9531
PRB3 proline-rich protein BstNI subfamily 3 -2.9348
DCK deoxycytidine kinase -2.9241
HAT1 histone acetyltransferase 1 -2.7631
FAM174B family with sequence similarity 174, member B -2.72253
PLBD1 phospholipase B domain containing 1 -2.6297
GIGYF2 GRB10 interacting GYF protein 2 -2.61095
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 -2.5905
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -2.54225
WDR77 WD repeat domain 77 -2.54213
CRISP3 cysteine-rich secretory protein 3 -2.53455
UBAP1 ubiquitin associated protein 1 -2.51513
DNAH7 dynein, axonemal, heavy chain 7 -2.5107
YIPF6 Yip1 domain family, member 6 -2.50874
FERRY3 FERRY endosomal RAB5 effector complex subunit 3 -2.49695
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.48327
CLDN10 claudin 10 -2.47435
EGF epidermal growth factor -2.46475
HMOX1 heme oxygenase 1 -2.46455
CNN2 calponin 2 -2.46175
PPP4R1 protein phosphatase 4, regulatory subunit 1 -2.4519
SNCAIP synuclein, alpha interacting protein -2.4372
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.42655
NGRN neugrin, neurite outgrowth associated -2.3948
KRT18 keratin 18, type I -2.3643
NBEAL2 neurobeachin-like 2 -2.34705
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.32605
DBR1 debranching RNA lariats 1 -2.31095
WNT5A wingless-type MMTV integration site family, member 5A -2.29603
AURKB aurora kinase B -2.27525
NQO2 NAD(P)H dehydrogenase, quinone 2 -2.27405
SPTBN2 spectrin, beta, non-erythrocytic 2 -2.27335
CENPB centromere protein B, 80kDa -2.2668
STATH statherin -2.2578
NSFL1C NSFL1 (p97) cofactor (p47) -2.25648
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) -2.25325
PRH1 proline-rich protein HaeIII subfamily 1 -2.24665
NXT1 nuclear transport factor 2-like export factor 1 -2.2379
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon -2.2204
FOXO4 forkhead box O4 -2.2017
MOSPD1 motile sperm domain containing 1 -2.18805
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 -2.182
PTPN6 protein tyrosine phosphatase, non-receptor type 6 -2.18095
MARCHF3 membrane associated ring-CH-type finger 3 -2.1799
RNF123 ring finger protein 123 -2.1724
FRY furry homolog (Drosophila) -2.16932
TP53BP1 tumor protein p53 binding protein 1 -2.1629
SH3GL1 SH3-domain GRB2-like 1 -2.15065
PIH1D1 PIH1 domain containing 1 -2.14335
ZNF552 zinc finger protein 552 -2.14285
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -2.13655
BLNK B-cell linker -2.1361
ADIPOR1 adiponectin receptor 1 -2.13415
LAPTM4A lysosomal protein transmembrane 4 alpha -2.13365
BCL7B B-cell CLL/lymphoma 7B -2.1267
BLMH bleomycin hydrolase -2.1223
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha -2.11905
CD46 CD46 molecule, complement regulatory protein -2.11737
YIPF1 Yip1 domain family, member 1 -2.11545
CRIPTO3 cripto, EGF-CFC family member 3 -2.1037
LOC122539214 Zinc finger protein LOC122539214 -2.09225
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 -2.0871
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.08182
RNF167 ring finger protein 167 -2.0772
BAZ1B bromodomain adjacent to zinc finger domain, 1B -2.06875
F3 coagulation factor III (thromboplastin, tissue factor) -2.0599
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.05495
RGL2 ral guanine nucleotide dissociation stimulator-like 2 -2.05185
GYPC glycophorin C (Gerbich blood group) -2.0516
ALDOC aldolase C, fructose-bisphosphate -2.0492
PANK2 pantothenate kinase 2 -2.0471
DZANK1 double zinc ribbon and ankyrin repeat domains 1 -2.0467
GSAP gamma-secretase activating protein -2.03967
SLC12A8 solute carrier family 12, member 8 -2.0386
S100A12 S100 calcium binding protein A12 -2.03465
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) -2.03275
PPL periplakin -2.02885
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -2.02315
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.00957
TMEM268 transmembrane protein 268 -2.00895
CETN2 centrin, EF-hand protein, 2 -2.00665
RHBDF1 rhomboid 5 homolog 1 (Drosophila) -2.00295