CRCGN014_HEPG2_3H:I22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tris(2-chloroethyl) phosphate 40.2 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

76 genes differentially expressed following the CRCGN014_HEPG2_3H:I22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CARMIL1 capping protein regulator and myosin 1 linker 1 8.28492
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 7.27281
DNM1 dynamin 1 5.41597
GPATCH8 G patch domain containing 8 5.35313
PNKP polynucleotide kinase 3'-phosphatase 4.95314
PPARG peroxisome proliferator-activated receptor gamma 4.63862
E2F2 E2F transcription factor 2 4.59005
ADGRE5 adhesion G protein-coupled receptor E5 4.55134
STIMATE STIM activating enhancer 4.15951
GPER1 G protein-coupled estrogen receptor 1 4.06237
ADGRG1 adhesion G protein-coupled receptor G1 3.31984
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 3.1171
MEST mesoderm specific transcript 3.00206
EVL Enah/Vasp-like 2.92679
KLHL9 kelch-like family member 9 2.86539
NUP205 nucleoporin 205kDa 2.84933
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.82449
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.72881
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G 2.62481
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) 2.42026
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2 2.41889
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 2.38456
CHEK2 checkpoint kinase 2 2.38393
JADE2 jade family PHD finger 2 2.32353
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 2.31982
MAGEA11 melanoma antigen family A11 2.28237
COL4A2 collagen, type IV, alpha 2 2.28021
NGFR nerve growth factor receptor 2.27292
NDFIP1 Nedd4 family interacting protein 1 2.27117
ZDHHC6 zinc finger, DHHC-type containing 6 2.24278
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 2.18998
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 2.18829
CD7 CD7 molecule 2.18476
KCTD5 potassium channel tetramerization domain containing 5 2.18242
CS citrate synthase 2.18017
ERCC5 excision repair cross-complementation group 5 2.15483
QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2 2.1354
PRR3 proline rich 3 2.09467
SFRP5 secreted frizzled-related protein 5 2.08337
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 2.08182
FABP2 fatty acid binding protein 2, intestinal 2.07987
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 2.07958
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B 2.06386
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.05322
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 2.02853
DCAF13 DDB1 and CUL4 associated factor 13 2.02824
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.006
POU3F4 POU class 3 homeobox 4 2.00578

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -9.55225
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -6.22808
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.35037
CDC20 cell division cycle 20 -5.28134
PCNA proliferating cell nuclear antigen -5.18247
ADI1 acireductone dioxygenase 1 -5.14087
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.73474
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.26328
TLR4 toll-like receptor 4 -3.85079
MAPK13 mitogen-activated protein kinase 13 -3.71068
CHMP4B charged multivesicular body protein 4B -3.63575
CCNB2 cyclin B2 -3.61325
TLCD3A TLC domain containing 3A -3.37732
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.99525
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.98568
ETFB electron-transfer-flavoprotein, beta polypeptide -2.64651
RFC2 replication factor C (activator 1) 2, 40kDa -2.58372
AKAP8 A kinase (PRKA) anchor protein 8 -2.34079
ZNF665 zinc finger protein 665 -2.33794
NRIP1 nuclear receptor interacting protein 1 -2.15047
STYXL1 serine/threonine/tyrosine interacting-like 1 -2.13129
ZNF426 zinc finger protein 426 -2.09792
ZNF432 zinc finger protein 432 -2.05686
ZNF611 zinc finger protein 611 -2.05611
HAUS2 HAUS augmin-like complex, subunit 2 -2.04154
FKBP10 FK506 binding protein 10, 65 kDa -2.03614
TOP2B topoisomerase (DNA) II beta 180kDa -2.01099
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 -2.00376