CRCGN014_HEPG2_3H:I24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description mitoxantrone 2.5 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

215 genes differentially expressed following the CRCGN014_HEPG2_3H:I24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STAP2 signal transducing adaptor family member 2 4.90205
CYCS cytochrome c, somatic 4.80788
USP6NL USP6 N-terminal like 4.63836
BTK Bruton agammaglobulinemia tyrosine kinase 4.52046
CIAO3 cytosolic iron-sulfur assembly component 3 4.35293
PNKP polynucleotide kinase 3'-phosphatase 4.34164
PRCP prolylcarboxypeptidase (angiotensinase C) 4.03416
LAGE3 L antigen family, member 3 3.68903
MEST mesoderm specific transcript 3.56295
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 3.48431
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.33112
SCRN1 secernin 1 3.24112
RSU1 Ras suppressor protein 1 3.20447
HEBP1 heme binding protein 1 3.12491
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.1129
COG4 component of oligomeric golgi complex 4 3.09412
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 3.03843
CSK c-src tyrosine kinase 2.94359
MTFR1 mitochondrial fission regulator 1 2.79938
OXCT1 3-oxoacid CoA transferase 1 2.73466
H2BC12 H2B clustered histone 12 2.64905
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.62609
HOXA10 homeobox A10 2.61192
PLSCR1 phospholipid scramblase 1 2.59668
SCGB1D1 secretoglobin, family 1D, member 1 2.57438
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 2.57307
TSEN34 TSEN34 tRNA splicing endonuclease subunit 2.51536
CRTAP cartilage associated protein 2.50683
PLS1 plastin 1 2.50544
PREPL prolyl endopeptidase-like 2.48479
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 2.47329
SKIC8 SKI8 subunit of superkiller complex 2.47261
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.45895
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 2.42358
NUCB2 nucleobindin 2 2.4142
TMEM109 transmembrane protein 109 2.4047
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C 2.40355
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 2.38092
PFKM phosphofructokinase, muscle 2.37725
CKMT1A creatine kinase, mitochondrial 1A 2.37513
CEMIP2 cell migration inducing hyaluronidase 2 2.36574
COPS4 COP9 signalosome subunit 4 2.3618
IL1B interleukin 1, beta 2.35884
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 2.35443
LAP3 leucine aminopeptidase 3 2.33705
MAPK3 mitogen-activated protein kinase 3 2.32056
DYNLT3 dynein, light chain, Tctex-type 3 2.30414
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 2.2944
ITFG1 integrin alpha FG-GAP repeat containing 1 2.27321
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 2.23431
EMC2 ER membrane protein complex subunit 2 2.22531
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.22419
H2BC9 H2B clustered histone 9 2.20621
AP2S1 adaptor-related protein complex 2, sigma 1 subunit 2.20475
IMMT inner membrane protein, mitochondrial 2.19891
PGM1 phosphoglucomutase 1 2.1894
PTTG1 pituitary tumor-transforming 1 2.1844
OXR1 oxidation resistance 1 2.17916
SPINT1 serine peptidase inhibitor, Kunitz type 1 2.17395
PPP4C protein phosphatase 4, catalytic subunit 2.15888
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 2.15414
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 2.1492
CTSV cathepsin V 2.14818
RUFY1 RUN and FYVE domain containing 1 2.13495
S100A14 S100 calcium binding protein A14 2.12641
NUP133 nucleoporin 133kDa 2.1166
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) 2.11126
EML3 echinoderm microtubule associated protein like 3 2.10592
WDTC1 WD and tetratricopeptide repeats 1 2.10432
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 2.10237
ELAC2 elaC ribonuclease Z 2 2.10172
TESK1 testis-specific kinase 1 2.0996
CNPPD1 cyclin Pas1/PHO80 domain containing 1 2.08981
ETAA1 Ewing tumor-associated antigen 1 2.08307
ERI3 ERI1 exoribonuclease family member 3 2.05066
DNASE1L1 deoxyribonuclease I-like 1 2.04219
CNGA1 cyclic nucleotide gated channel alpha 1 2.04131
HAT1 histone acetyltransferase 1 2.03654
CHMP6 charged multivesicular body protein 6 2.03376
FGD1 FYVE, RhoGEF and PH domain containing 1 2.03363
OVGP1 oviductal glycoprotein 1, 120kDa 2.03144
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 2.02621
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit 2.02594
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.02075
KRCC1 lysine-rich coiled-coil 1 2.02056
PRC1 protein regulator of cytokinesis 1 2.01124
IGSF3 immunoglobulin superfamily, member 3 2.01086
DIPK1A divergent protein kinase domain 1A 2.00974
IFT81 intraflagellar transport 81 2.00462
FAM171A1 family with sequence similarity 171, member A1 2.0035

decreased expression

Symbol Name Standardized Value
FASTKD5 FAST kinase domains 5 -10.0
MYC v-myc avian myelocytomatosis viral oncogene homolog -10.0
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -7.72483
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -7.07331
UFM1 ubiquitin-fold modifier 1 -6.89672
RPP38 ribonuclease P/MRP 38kDa subunit -6.74461
TRIB1 tribbles pseudokinase 1 -6.06025
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -5.67813
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -5.51828
DDIT4 DNA-damage-inducible transcript 4 -5.33561
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -5.02158
RFC2 replication factor C (activator 1) 2, 40kDa -5.00163
UBE3C ubiquitin protein ligase E3C -4.98284
KLHL21 kelch-like family member 21 -4.89756
IER3 immediate early response 3 -4.69427
KEAP1 kelch-like ECH-associated protein 1 -4.61675
ZMIZ1 zinc finger, MIZ-type containing 1 -4.09213
ZBTB35 zinc finger and BTB domain containing 35 -3.99101
ADO 2-aminoethanethiol (cysteamine) dioxygenase -3.9301
PCNA proliferating cell nuclear antigen -3.80969
FOSL1 FOS-like antigen 1 -3.78421
WASHC4 WASH complex subunit 4 -3.66695
SMAD3 SMAD family member 3 -3.4652
ZDHHC6 zinc finger, DHHC-type containing 6 -3.43657
TRIB3 tribbles pseudokinase 3 -3.39982
GRWD1 glutamate-rich WD repeat containing 1 -3.32797
NOP56 NOP56 ribonucleoprotein -3.32516
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 -3.21647
BIRC2 baculoviral IAP repeat containing 2 -3.16676
HMOX1 heme oxygenase 1 -3.12268
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.10892
NRBF2 nuclear receptor binding factor 2 -3.08818
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.04025
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.92665
JMJD6 jumonji domain containing 6 -2.91878
CGRRF1 cell growth regulator with ring finger domain 1 -2.86755
FRS2 fibroblast growth factor receptor substrate 2 -2.86257
MAD2L1BP MAD2L1 binding protein -2.85945
GOLT1B golgi transport 1B -2.85552
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.84921
ZBTB24 zinc finger and BTB domain containing 24 -2.83116
TXLNA taxilin alpha -2.82553
RPL36 ribosomal protein L36 -2.67346
RBM15 RNA binding motif protein 15 -2.66095
THAP11 THAP domain containing 11 -2.65972
NCK1 NCK adaptor protein 1 -2.60728
SNX11 sorting nexin 11 -2.59583
RANBP6 RAN binding protein 6 -2.55548
ZNF668 zinc finger protein 668 -2.5171
MAT2A methionine adenosyltransferase II, alpha -2.51673
PLAGL2 pleiomorphic adenoma gene-like 2 -2.50032
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.48436
HEATR1 HEAT repeat containing 1 -2.48054
KLHL9 kelch-like family member 9 -2.45308
DCK deoxycytidine kinase -2.44541
PUF60 poly-U binding splicing factor 60KDa -2.40178
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.39324
CASC3 cancer susceptibility candidate 3 -2.38545
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 -2.38252
IP6K2 inositol hexakisphosphate kinase 2 -2.36603
LY6G5C lymphocyte antigen 6 complex, locus G5C -2.36304
SLC25A46 solute carrier family 25, member 46 -2.35299
TMEM39A transmembrane protein 39A -2.34861
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.33458
CCNF cyclin F -2.33153
ZNF140 zinc finger protein 140 -2.32574
ZNF593 zinc finger protein 593 -2.32056
IL4R interleukin 4 receptor -2.31822
GCC1 GRIP and coiled-coil domain containing 1 -2.30332
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 -2.28959
POLR1D polymerase (RNA) I polypeptide D, 16kDa -2.2853
SNRPF small nuclear ribonucleoprotein polypeptide F -2.28338
NOCT nocturnin -2.27231
SRRD SRR1 domain containing -2.2676
IER2 immediate early response 2 -2.26576
ALAS1 5'-aminolevulinate synthase 1 -2.2531
FOXN2 forkhead box N2 -2.24148
ZZZ3 zinc finger, ZZ-type containing 3 -2.23929
ZNF107 zinc finger protein 107 -2.23281
AADAC arylacetamide deacetylase -2.21365
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.21209
ANKRD40 ankyrin repeat domain 40 -2.21
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.20962
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I -2.19175
MSH6 mutS homolog 6 -2.18099
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G -2.18021
GNAS GNAS complex locus -2.17771
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1 -2.17521
HLA-A major histocompatibility complex, class I, A -2.16923
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 -2.1616
KRT7 keratin 7, type II -2.14838
MED9 mediator complex subunit 9 -2.14717
SESN1 sestrin 1 -2.146
MGA MGA, MAX dimerization protein -2.14435
TBPL1 TBP-like 1 -2.14007
INTS6 integrator complex subunit 6 -2.13734
CDK7 cyclin-dependent kinase 7 -2.13191
WDR43 WD repeat domain 43 -2.12384
ZNF232 zinc finger protein 232 -2.12087
PLP1 proteolipid protein 1 -2.11892
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.11291
SIAH1 siah E3 ubiquitin protein ligase 1 -2.09881
AKAP11 A kinase (PRKA) anchor protein 11 -2.09807
PPP1R8 protein phosphatase 1, regulatory subunit 8 -2.09027
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.08701
ACAA1 acetyl-CoA acyltransferase 1 -2.07094
CDC6 cell division cycle 6 -2.07027
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 -2.06371
CEBPB CCAAT/enhancer binding protein (C/EBP), beta -2.06289
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa -2.06017
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.05558
DDRGK1 DDRGK domain containing 1 -2.05308
CDC25A cell division cycle 25A -2.05056
POM121C POM121 transmembrane nucleoporin C -2.04356
TBC1D10C TBC1 domain family, member 10C -2.03196
ATP8B4 ATPase, class I, type 8B, member 4 -2.0308
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma -2.03015
ZNF574 zinc finger protein 574 -2.02445
ZNF267 zinc finger protein 267 -2.02426
CCDC59 coiled-coil domain containing 59 -2.02419
RND1 Rho family GTPase 1 -2.0177
PROSER1 proline and serine rich 1 -2.01141
ZNF281 zinc finger protein 281 -2.00771
STX11 syntaxin 11 -2.0041
CALU calumenin -2.00112