CRCGN014_HEPG2_3H:J02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description triphenylphosphine oxide 20.12 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN014_HEPG2_3H:J02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 8.03705
HOXA10 homeobox A10 6.91197
STIMATE STIM activating enhancer 6.00383
DYNLT3 dynein, light chain, Tctex-type 3 4.72039
PPARG peroxisome proliferator-activated receptor gamma 4.60984
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.54091
C2CD2 C2 calcium-dependent domain containing 2 4.35156
PEX11A peroxisomal biogenesis factor 11 alpha 4.01395
CARMIL1 capping protein regulator and myosin 1 linker 1 3.98929
CBR3 carbonyl reductase 3 3.38488
NOTCH1 notch 1 3.35571
ADRB2 adrenoceptor beta 2, surface 3.32665
PFKL phosphofructokinase, liver 3.15088
GATD3 glutamine amidotransferase class 1 domain containing 3 3.13691
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.07709
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 2.96863
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.90114
CSK c-src tyrosine kinase 2.89716
TREM1 triggering receptor expressed on myeloid cells 1 2.85865
STK10 serine/threonine kinase 10 2.74924
GSTZ1 glutathione S-transferase zeta 1 2.70326
MAP7 microtubule-associated protein 7 2.66992
JADE2 jade family PHD finger 2 2.63149
CHN1 chimerin 1 2.50215
TNS3 tensin 3 2.50125
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing 2.36882
TEX10 testis expressed 10 2.35037
PMP2 peripheral myelin protein 2 2.30926
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 2.30556
MTG1 mitochondrial ribosome-associated GTPase 1 2.28943
RRAGA Ras-related GTP binding A 2.1192
THEM6 thioesterase superfamily member 6 2.10285
EXOSC4 exosome component 4 2.09654
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 2.09418
FCN1 ficolin (collagen/fibrinogen domain containing) 1 2.02534

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -6.27492
KDM3A lysine (K)-specific demethylase 3A -5.18822
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.16039
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.0
CDC20 cell division cycle 20 -4.82921
OXA1L oxidase (cytochrome c) assembly 1-like -4.60609
TRIB3 tribbles pseudokinase 3 -4.38251
CCNB2 cyclin B2 -3.21758
SPAG4 sperm associated antigen 4 -3.20682
NVL nuclear VCP-like -3.15616
PRPF4 pre-mRNA processing factor 4 -2.80804
HSPA8 heat shock 70kDa protein 8 -2.77847
RFC2 replication factor C (activator 1) 2, 40kDa -2.50424
WDR7 WD repeat domain 7 -2.35412
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.30398
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.2383
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.1587
MZB1 marginal zone B and B1 cell-specific protein -2.04552
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.04044
EIF2D eukaryotic translation initiation factor 2D -2.03337
GALR3 galanin receptor 3 -2.00316
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -2.0031