CRCGN014_HEPG2_3H:J03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description trisodium 5-oxo-1-(4-sulfonatophenyl)-4-[(e)-(4-sulfonatophenyl)diazenyl]-2,5-dihydro-1h-pyrazole-3-carboxylate 20.58 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

123 genes differentially expressed following the CRCGN014_HEPG2_3H:J03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 7.30118
ANO1 anoctamin 1, calcium activated chloride channel 7.0361
STK10 serine/threonine kinase 10 5.90857
SNAP25 synaptosomal-associated protein, 25kDa 5.34784
RPL39L ribosomal protein L39-like 5.11815
C2CD2 C2 calcium-dependent domain containing 2 5.04727
MAP7 microtubule-associated protein 7 5.01601
MOK MOK protein kinase 4.86592
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.85888
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.84922
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.68347
MNAT1 MNAT CDK-activating kinase assembly factor 1 4.61666
STIMATE STIM activating enhancer 4.12574
KIFBP kinesin family binding protein 3.97592
E2F2 E2F transcription factor 2 3.92759
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.88184
PRKCH protein kinase C, eta 3.86988
GATA3 GATA binding protein 3 3.83264
ABHD6 abhydrolase domain containing 6 3.69622
SYNGAP1 synaptic Ras GTPase activating protein 1 3.53753
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 3.5343
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.5236
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 3.49583
CHN1 chimerin 1 3.44003
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 3.40269
CCL2 chemokine (C-C motif) ligand 2 3.10848
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.98158
CLSTN2 calsyntenin 2 2.95443
SHB Src homology 2 domain containing adaptor protein B 2.94701
ADRB2 adrenoceptor beta 2, surface 2.935
CYCS cytochrome c, somatic 2.83311
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 2.765
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.73388
EPHA3 EPH receptor A3 2.69901
CRTAP cartilage associated protein 2.62584
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.60685
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.53632
LCAT lecithin-cholesterol acyltransferase 2.49692
SNX7 sorting nexin 7 2.37899
STAT5B signal transducer and activator of transcription 5B 2.36079
SIX1 SIX homeobox 1 2.34504
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 2.3124
CXCL2 chemokine (C-X-C motif) ligand 2 2.28731
ERCC6 excision repair cross-complementation group 6 2.28634
GPR176 G protein-coupled receptor 176 2.2819
PNN pinin, desmosome associated protein 2.27839
AFAP1 actin filament associated protein 1 2.26644
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.23415
SLC66A3 solute carrier family 66 member 3 2.1936
PARP1 poly (ADP-ribose) polymerase 1 2.18761
ANXA6 annexin A6 2.18425
ZNF208 zinc finger protein 208 2.18309
PRR5 proline rich 5 (renal) 2.16524
TMEM268 transmembrane protein 268 2.15502
KLRC4 killer cell lectin-like receptor subfamily C, member 4 2.14747
TRIM58 tripartite motif containing 58 2.13176
SNRPE small nuclear ribonucleoprotein polypeptide E 2.11777
CEP63 centrosomal protein 63kDa 2.11592
TBP TATA box binding protein 2.11214
STXBP2 syntaxin binding protein 2 2.11206
MCF2 MCF.2 cell line derived transforming sequence 2.11108
REPS2 RALBP1 associated Eps domain containing 2 2.10548
MAGEC1 melanoma antigen family C1 2.10385
CFAP44 cilia and flagella associated protein 44 2.09882
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.09683
WDR41 WD repeat domain 41 2.08814
TAC1 tachykinin, precursor 1 2.07231
CNPY3 canopy FGF signaling regulator 3 2.06446
SP4 Sp4 transcription factor 2.06381
EGLN1 egl-9 family hypoxia-inducible factor 1 2.03636
KLRC3 killer cell lectin-like receptor subfamily C, member 3 2.02948
ZNF589 zinc finger protein 589 2.02683
RHOC ras homolog family member C 2.02092
DONSON downstream neighbor of SON 2.01648
ZKSCAN8 zinc finger with KRAB and SCAN domains 8 2.01368
CBR3 carbonyl reductase 3 2.00992
ZNF84 zinc finger protein 84 2.00607
IL12A interleukin 12A 2.00315

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -7.21548
LDHD lactate dehydrogenase D -5.24974
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.16512
LOC124907782 dual specificity protein phosphatase 22 -4.97573
COG2 component of oligomeric golgi complex 2 -4.83412
OXA1L oxidase (cytochrome c) assembly 1-like -4.665
PEG10 paternally expressed 10 -3.66972
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.65274
BPHL biphenyl hydrolase-like (serine hydrolase) -2.92687
ADI1 acireductone dioxygenase 1 -2.87267
TLCD3A TLC domain containing 3A -2.81243
FAIM Fas apoptotic inhibitory molecule -2.71022
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.6851
EGF epidermal growth factor -2.55987
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D -2.47972
REEP5 receptor accessory protein 5 -2.46306
TBC1D31 TBC1 domain family, member 31 -2.44595
ATG4A autophagy related 4A, cysteine peptidase -2.38058
AHDC1 AT hook, DNA binding motif, containing 1 -2.34575
ARID5B AT rich interactive domain 5B (MRF1-like) -2.31772
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 -2.2887
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.286
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 -2.27564
RGS2 regulator of G-protein signaling 2 -2.26402
FASTKD5 FAST kinase domains 5 -2.2421
NGRN neugrin, neurite outgrowth associated -2.24181
VAT1 vesicle amine transport 1 -2.22602
NUP85 nucleoporin 85kDa -2.21343
PECR peroxisomal trans-2-enoyl-CoA reductase -2.21168
PCNA proliferating cell nuclear antigen -2.15658
TXNDC9 thioredoxin domain containing 9 -2.14518
COA7 cytochrome c oxidase assembly factor 7 (putative) -2.09632
RPL3L ribosomal protein L3-like -2.08414
MRPS7 mitochondrial ribosomal protein S7 -2.07987
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 -2.07208
IRF2BP1 interferon regulatory factor 2 binding protein 1 -2.06891
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.05246
LEMD3 LEM domain containing 3 -2.04781
C5 complement component 5 -2.04544
COG4 component of oligomeric golgi complex 4 -2.03855
TMEM164 transmembrane protein 164 -2.03473
TMEM126B transmembrane protein 126B -2.03311
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion -2.03207
ZMIZ1 zinc finger, MIZ-type containing 1 -2.02948
MTA2 metastasis associated 1 family, member 2 -2.01155