CRCGN014_HEPG2_3H:J04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dimethoxybenzidine.2hcl 40.2 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

37 genes differentially expressed following the CRCGN014_HEPG2_3H:J04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHMP6 charged multivesicular body protein 6 5.86155
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.75716
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 3.66672
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.39662
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.08564
SNAP25 synaptosomal-associated protein, 25kDa 2.94991
NOSIP nitric oxide synthase interacting protein 2.87211
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.82203
DIPK1A divergent protein kinase domain 1A 2.76476
PLSCR3 phospholipid scramblase 3 2.69114
USP6NL USP6 N-terminal like 2.67673
MAP7 microtubule-associated protein 7 2.62351
HYOU1 hypoxia up-regulated 1 2.60494
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.57557
TIAM1 T-cell lymphoma invasion and metastasis 1 2.25847
SLC35B1 solute carrier family 35, member B1 2.20407
GPATCH8 G patch domain containing 8 2.13962
GPER1 G protein-coupled estrogen receptor 1 2.00107

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -7.35625
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -7.09493
CDC20 cell division cycle 20 -6.88844
LDHD lactate dehydrogenase D -6.43907
CCNB2 cyclin B2 -6.43205
HAT1 histone acetyltransferase 1 -3.90574
UGDH UDP-glucose 6-dehydrogenase -3.1239
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.09021
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.02072
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.82625
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.776
SPAG4 sperm associated antigen 4 -2.49175
NRIP1 nuclear receptor interacting protein 1 -2.40783
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.17459
SNX11 sorting nexin 11 -2.16079
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.1599
BCL2L2 BCL2-like 2 -2.13637
GNAS GNAS complex locus -2.0909
EIF5 eukaryotic translation initiation factor 5 -2.06393