CRCGN014_HEPG2_3H:J05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (3s,16r,17s)-17-acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthrene-16-carbonitrile 21.08 um perturbation at 3 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

43 genes differentially expressed following the CRCGN014_HEPG2_3H:J05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 5.17006
AMDHD2 amidohydrolase domain containing 2 4.07361
ANO1 anoctamin 1, calcium activated chloride channel 3.90222
CASP10 caspase 10, apoptosis-related cysteine peptidase 3.7804
MSRA methionine sulfoxide reductase A 3.77822
ADGRE5 adhesion G protein-coupled receptor E5 3.77308
SYNE2 spectrin repeat containing, nuclear envelope 2 3.74652
CIAO3 cytosolic iron-sulfur assembly component 3 3.4158
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.30204
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.24022
ADRB2 adrenoceptor beta 2, surface 3.23825
PPARG peroxisome proliferator-activated receptor gamma 3.051
HOXA10 homeobox A10 2.82047
MAMLD1 mastermind-like domain containing 1 2.75724
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.71825
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.53754
VGLL4 vestigial-like family member 4 2.48294
GSTZ1 glutathione S-transferase zeta 1 2.46149
HPRT1 hypoxanthine phosphoribosyltransferase 1 2.45379
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.34005
JADE2 jade family PHD finger 2 2.22621
TRAM2 translocation associated membrane protein 2 2.18028
MAP7 microtubule-associated protein 7 2.15109
DIPK1A divergent protein kinase domain 1A 2.09971
CD33 CD33 molecule 2.06703
MXRA7 matrix-remodelling associated 7 2.03459

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -5.60386
TLR4 toll-like receptor 4 -5.09174
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.33071
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.1862
TRIB3 tribbles pseudokinase 3 -4.13905
SCAND1 SCAN domain containing 1 -3.94682
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.90222
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.52498
TXNDC9 thioredoxin domain containing 9 -3.2223
SLC35F2 solute carrier family 35, member F2 -3.17837
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.05381
CCNB2 cyclin B2 -2.97174
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.83068
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha -2.32448
RNF187 ring finger protein 187 -2.07826
CNOT7 CCR4-NOT transcription complex, subunit 7 -2.07722
GTPBP2 GTP binding protein 2 -2.0613