CRCGN014_HEPG2_3H:J06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3-nitropropanoic acid 21.83 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN014_HEPG2_3H:J06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 7.36309
C2CD2 C2 calcium-dependent domain containing 2 7.32741
MAP7 microtubule-associated protein 7 7.25604
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.47586
TIAM1 T-cell lymphoma invasion and metastasis 1 4.71331
CBR3 carbonyl reductase 3 3.8019
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.68068
GSTZ1 glutathione S-transferase zeta 1 3.52854
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.24291
CIAO3 cytosolic iron-sulfur assembly component 3 3.22338
ZBTB18 zinc finger and BTB domain containing 18 3.18564
CXCL2 chemokine (C-X-C motif) ligand 2 3.17111
BACE2 beta-site APP-cleaving enzyme 2 3.12589
PRR15L proline rich 15-like 2.91713
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.88169
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.77172
STIMATE STIM activating enhancer 2.47188
CYCS cytochrome c, somatic 2.35416
PKN1 protein kinase N1 2.30154
VGLL4 vestigial-like family member 4 2.29524
SIRT3 sirtuin 3 2.21799
TREM1 triggering receptor expressed on myeloid cells 1 2.1782
DYNLT3 dynein, light chain, Tctex-type 3 2.15641
COPS7A COP9 signalosome subunit 7A 2.06166
CCNF cyclin F 2.00244

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -7.06628
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.23139
NT5DC2 5'-nucleotidase domain containing 2 -4.16244
PEG10 paternally expressed 10 -3.69787
CCNB2 cyclin B2 -3.66555
SPAG4 sperm associated antigen 4 -3.64973
DSG2 desmoglein 2 -3.6174
MAPK13 mitogen-activated protein kinase 13 -3.10345
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.09558
PCCB propionyl CoA carboxylase, beta polypeptide -2.80674
TLCD3A TLC domain containing 3A -2.68595
TOR1A torsin family 1, member A (torsin A) -2.61271
EIF5 eukaryotic translation initiation factor 5 -2.55868
GNAS GNAS complex locus -2.54915
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.48432
LDHD lactate dehydrogenase D -2.42493
SNX11 sorting nexin 11 -2.23016
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.1715
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.07957
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.05287