CRCGN014_HEPG2_3H:J07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description s,s'-1,4-dioxane-2,3-diyl o,o,o',o'-tetraethyl diphosphorodithioate 21.47 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN014_HEPG2_3H:J07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HSPA1A heat shock 70kDa protein 1A 7.21732
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 7.12178
ANO1 anoctamin 1, calcium activated chloride channel 6.05858
PPARG peroxisome proliferator-activated receptor gamma 4.0134
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.94667
BAG3 BCL2-associated athanogene 3 3.78118
SNAP25 synaptosomal-associated protein, 25kDa 3.67146
MYLK myosin light chain kinase 3.6416
TXNRD1 thioredoxin reductase 1 3.42945
NOTCH1 notch 1 3.36003
CXCL2 chemokine (C-X-C motif) ligand 2 3.34039
STIMATE STIM activating enhancer 3.25927
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 3.18617
CSK c-src tyrosine kinase 3.14214
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.92078
HSPA1B heat shock 70kDa protein 1B 2.54194
DDIT4 DNA-damage-inducible transcript 4 2.53075
COPS7A COP9 signalosome subunit 7A 2.3596
ZFP36 ZFP36 ring finger protein 2.31572
KIF20A kinesin family member 20A 2.23823
GATA2 GATA binding protein 2 2.22776
MAP7 microtubule-associated protein 7 2.18051
MCUR1 mitochondrial calcium uniporter regulator 1 2.16887
FCHO1 FCH domain only 1 2.12988
CHN1 chimerin 1 2.05942
MPC2 mitochondrial pyruvate carrier 2 2.0171
ABHD4 abhydrolase domain containing 4 2.00037

decreased expression

Symbol Name Standardized Value
CD320 CD320 molecule -6.94388
DNM1L dynamin 1-like -4.39371
CCNB2 cyclin B2 -3.64372
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.3973
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.14092
PCNA proliferating cell nuclear antigen -2.79694
MRPS2 mitochondrial ribosomal protein S2 -2.60444
TLR4 toll-like receptor 4 -2.47483
NGRN neugrin, neurite outgrowth associated -2.32545
ZNF586 zinc finger protein 586 -2.20342
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.19329
EIF5 eukaryotic translation initiation factor 5 -2.19205
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.12445
PDZD2 PDZ domain containing 2 -2.07673
TNF tumor necrosis factor -2.0209
YJU2 YJU2 splicing factor homolog -2.00654