| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | n,n-dimethyl-n'-[3-(trifluoromethyl)phenyl]urea 20.1 um perturbation at 3 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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88 genes differentially expressed following the CRCGN014_HEPG2_3H:J08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| BAX | BCL2-associated X protein | 7.04452 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 4.98545 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 4.98203 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 4.87765 |
| PPARG | peroxisome proliferator-activated receptor gamma | 4.87645 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 3.4646 |
| TPD52L2 | tumor protein D52-like 2 | 3.2907 |
| TSPAN6 | tetraspanin 6 | 3.15418 |
| SLC39A7 | solute carrier family 39 (zinc transporter), member 7 | 2.9787 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 2.89 |
| DLST | dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) | 2.86055 |
| LMNB1 | lamin B1 | 2.76185 |
| LARS1 | leucyl-tRNA synthetase 1 | 2.7203 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 2.6567 |
| EVL | Enah/Vasp-like | 2.62385 |
| PLSCR3 | phospholipid scramblase 3 | 2.54768 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 2.51315 |
| CDC42SE1 | CDC42 small effector 1 | 2.4849 |
| WDR43 | WD repeat domain 43 | 2.4761 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 2.44385 |
| ALDOC | aldolase C, fructose-bisphosphate | 2.3722 |
| TEX10 | testis expressed 10 | 2.3036 |
| GLTP | glycolipid transfer protein | 2.25575 |
| FAM216A | family with sequence similarity 216, member A | 2.24055 |
| TBXA2R | thromboxane A2 receptor | 2.22076 |
| SECISBP2 | SECIS binding protein 2 | 2.2143 |
| STRN3 | striatin, calmodulin binding protein 3 | 2.20117 |
| CTSZ | cathepsin Z | 2.1738 |
| HAMP | hepcidin antimicrobial peptide | 2.15775 |
| SPRR1A | small proline-rich protein 1A | 2.1322 |
| SPRR2B | small proline-rich protein 2B | 2.13145 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | 2.08463 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | 2.084 |
| WDR76 | WD repeat domain 76 | 2.0826 |
| CRLF3 | cytokine receptor-like factor 3 | 2.0801 |
| RHOC | ras homolog family member C | 2.06305 |
| NPM3 | nucleophosmin/nucleoplasmin 3 | 2.05985 |
| S100A7 | S100 calcium binding protein A7 | 2.05065 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 2.05 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 2.0449 |
| OSTF1 | osteoclast stimulating factor 1 | 2.04305 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | 2.01475 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZNF586 | zinc finger protein 586 | -10.0 |
| GOLT1B | golgi transport 1B | -5.3236 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -5.157 |
| PLK1 | polo-like kinase 1 | -5.0 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -4.972 |
| PCNA | proliferating cell nuclear antigen | -4.7142 |
| TRIB3 | tribbles pseudokinase 3 | -4.42645 |
| DNM1L | dynamin 1-like | -4.36885 |
| ADI1 | acireductone dioxygenase 1 | -4.2279 |
| TLR4 | toll-like receptor 4 | -3.8948 |
| CCNB2 | cyclin B2 | -3.74145 |
| GNAS | GNAS complex locus | -3.53001 |
| TLCD3A | TLC domain containing 3A | -3.24915 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.14835 |
| EGF | epidermal growth factor | -2.89715 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.8689 |
| SNX11 | sorting nexin 11 | -2.82655 |
| TBC1D31 | TBC1 domain family, member 31 | -2.7993 |
| NXF3 | nuclear RNA export factor 3 | -2.64155 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | -2.6132 |
| IPO13 | importin 13 | -2.46975 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -2.4693 |
| RNF167 | ring finger protein 167 | -2.36395 |
| ZNF134 | zinc finger protein 134 | -2.3303 |
| MRPL33 | mitochondrial ribosomal protein L33 | -2.3194 |
| BLCAP | bladder cancer associated protein | -2.25265 |
| ZNF671 | zinc finger protein 671 | -2.25135 |
| PPP1R14D | protein phosphatase 1, regulatory (inhibitor) subunit 14D | -2.24775 |
| SH3BP4 | SH3-domain binding protein 4 | -2.23365 |
| ZNF551 | zinc finger protein 551 | -2.21875 |
| GGCT | gamma-glutamylcyclotransferase | -2.2053 |
| SMAD7 | SMAD family member 7 | -2.19535 |
| GORASP2 | golgi reassembly stacking protein 2, 55kDa | -2.14318 |
| CNOT3 | CCR4-NOT transcription complex, subunit 3 | -2.1406 |
| TMEM39B | transmembrane protein 39B | -2.11795 |
| LCMT1 | leucine carboxyl methyltransferase 1 | -2.1082 |
| PPP2R2D | protein phosphatase 2, regulatory subunit B, delta | -2.10545 |
| TXNDC9 | thioredoxin domain containing 9 | -2.10278 |
| ZNF211 | zinc finger protein 211 | -2.07795 |
| DAPK1 | death-associated protein kinase 1 | -2.07253 |
| ZKSCAN4 | zinc finger with KRAB and SCAN domains 4 | -2.06625 |
| GABRB3 | gamma-aminobutyric acid (GABA) A receptor, beta 3 | -2.0542 |
| ZNF304 | zinc finger protein 304 | -2.04965 |
| SAP130 | Sin3A-associated protein, 130kDa | -2.0413 |
| HJURP | Holliday junction recognition protein | -2.02495 |
| STUM | stum, mechanosensory transduction mediator homolog | -2.0116 |
