CRCGN014_HEPG2_3H:J10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,4-dimethyl-5h-pyrido[4,3-b]indol-3-amine acetate 20.64 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

351 genes differentially expressed following the CRCGN014_HEPG2_3H:J10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.85288
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 6.43679
SKIC2 SKI2 subunit of superkiller complex 5.88635
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.96918
KHDC4 KH domain containing 4, pre-mRNA splicing factor 4.60168
SLC75A1 solute carrier family 75 member 1 4.46188
C2CD2 C2 calcium-dependent domain containing 2 4.26994
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 4.16723
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 4.13571
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 4.12232
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.96695
GADD45A growth arrest and DNA-damage-inducible, alpha 3.88037
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.71906
SCRN1 secernin 1 3.68154
FAT1 FAT atypical cadherin 1 3.6733
PNKP polynucleotide kinase 3'-phosphatase 3.66075
EPN2 epsin 2 3.65174
CCP110 centriolar coiled coil protein 110kDa 3.64773
NPDC1 neural proliferation, differentiation and control, 1 3.57309
HSPA1A heat shock 70kDa protein 1A 3.41967
LYN LYN proto-oncogene, Src family tyrosine kinase 3.40139
TNIP1 TNFAIP3 interacting protein 1 3.39032
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.35038
GSTZ1 glutathione S-transferase zeta 1 3.33645
LLGL2 lethal giant larvae homolog 2 (Drosophila) 3.27426
PFKL phosphofructokinase, liver 3.26951
LSR lipolysis stimulated lipoprotein receptor 3.25812
CCL2 chemokine (C-C motif) ligand 2 3.2122
SMIM40 small integral membrane protein 40 3.16837
PRRC2A proline-rich coiled-coil 2A 3.16325
ATP11B ATPase, class VI, type 11B 3.14476
COG4 component of oligomeric golgi complex 4 3.14315
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.06865
MVP major vault protein 3.06472
TMEM109 transmembrane protein 109 3.06463
CCND3 cyclin D3 3.04528
RGL2 ral guanine nucleotide dissociation stimulator-like 2 3.00082
FOXO4 forkhead box O4 2.99546
MAP7 microtubule-associated protein 7 2.98964
CBR3 carbonyl reductase 3 2.95046
TRIM13 tripartite motif containing 13 2.95015
CUTA cutA divalent cation tolerance homolog (E. coli) 2.94845
RUSC2 RUN and SH3 domain containing 2 2.9462
GPS1 G protein pathway suppressor 1 2.94405
E4F1 E4F transcription factor 1 2.94164
H1-10 H1.10 linker histone 2.9349
CEP131 centrosomal protein 131kDa 2.92802
RAB4A RAB4A, member RAS oncogene family 2.92434
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 2.8926
PILRB paired immunoglobin-like type 2 receptor beta 2.89138
C5 complement component 5 2.87464
CCNA1 cyclin A1 2.8638
VAC14 Vac14 homolog (S. cerevisiae) 2.84928
WHRN whirlin 2.81503
FHIP2B FHF complex subunit HOOK interacting protein 2B 2.80727
EFHD1 EF-hand domain family, member D1 2.79948
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.78502
VGLL4 vestigial-like family member 4 2.7708
IL1B interleukin 1, beta 2.76882
CXCR4 chemokine (C-X-C motif) receptor 4 2.76407
DIPK1A divergent protein kinase domain 1A 2.75132
APEH acylaminoacyl-peptide hydrolase 2.72899
METTL25B methyltransferase like 25B 2.72494
SORBS3 sorbin and SH3 domain containing 3 2.7129
TP53BP2 tumor protein p53 binding protein 2 2.70918
KIFBP kinesin family binding protein 2.69286
TRAP1 TNF receptor-associated protein 1 2.68983
FAM110B family with sequence similarity 110, member B 2.68805
SCAND1 SCAN domain containing 1 2.66968
HSF1 heat shock transcription factor 1 2.66635
SNX7 sorting nexin 7 2.6635
TSPAN4 tetraspanin 4 2.66048
BAG6 BCL2-associated athanogene 6 2.65327
COPS7B COP9 signalosome subunit 7B 2.64654
NANOG Nanog homeobox 2.62718
TESK1 testis-specific kinase 1 2.61018
SHARPIN SHANK-associated RH domain interactor 2.60608
MPST mercaptopyruvate sulfurtransferase 2.60326
HDAC9 histone deacetylase 9 2.59237
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 2.59086
KIF13B kinesin family member 13B 2.57362
CYCS cytochrome c, somatic 2.55569
GHR growth hormone receptor 2.54726
PTMS parathymosin 2.52537
CDK10 cyclin-dependent kinase 10 2.52027
COL9A2 collagen, type IX, alpha 2 2.50877
SLC26A6 solute carrier family 26 (anion exchanger), member 6 2.49307
HTRA1 HtrA serine peptidase 1 2.49049
MMP24OS MMP24 opposite strand 2.47649
VARS1 valyl-tRNA synthetase 1 2.47114
TBPL1 TBP-like 1 2.46954
FGD1 FYVE, RhoGEF and PH domain containing 1 2.46294
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.45173
FGFR4 fibroblast growth factor receptor 4 2.44101
MBOAT2 membrane bound O-acyltransferase domain containing 2 2.42827
PTPRK protein tyrosine phosphatase, receptor type, K 2.41308
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 2.41299
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.40126
GARRE1 granule associated Rac and RHOG effector 1 2.39842
PHF1 PHD finger protein 1 2.38751
SPG11 spastic paraplegia 11 (autosomal recessive) 2.3873
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 2.38447
CEP57 centrosomal protein 57kDa 2.38075
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa 2.37265
ZNF768 zinc finger protein 768 2.36222
PPDPF pancreatic progenitor cell differentiation and proliferation factor 2.348
HDAC5 histone deacetylase 5 2.34791
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.32527
CAMTA2 calmodulin binding transcription activator 2 2.31427
ATP5F1D ATP synthase F1 subunit delta 2.30581
ELAC2 elaC ribonuclease Z 2 2.30499
ACTN4 actinin, alpha 4 2.30409
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.30304
STRN4 striatin, calmodulin binding protein 4 2.29354
PPP1R13L protein phosphatase 1, regulatory subunit 13 like 2.29295
NEK3 NIMA-related kinase 3 2.28794
STK25 serine/threonine kinase 25 2.28491
H2BC21 H2B clustered histone 21 2.27955
CDIP1 cell death-inducing p53 target 1 2.26299
WNT5B wingless-type MMTV integration site family, member 5B 2.26274
INPP1 inositol polyphosphate-1-phosphatase 2.253
RECQL4 RecQ protein-like 4 2.2508
SCN3A sodium channel, voltage gated, type III alpha subunit 2.24299
PRR14 proline rich 14 2.23859
ECI1 enoyl-CoA delta isomerase 1 2.2381
GALT galactose-1-phosphate uridylyltransferase 2.23763
ALDH1B1 aldehyde dehydrogenase 1 family, member B1 2.22587
THOC6 THO complex 6 2.2212
CIAO3 cytosolic iron-sulfur assembly component 3 2.21872
MSH5 mutS homolog 5 2.20708
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 2.20532
RNF43 ring finger protein 43 2.20509
ZNF274 zinc finger protein 274 2.18816
DNAAF5 dynein, axonemal, assembly factor 5 2.18562
CUEDC1 CUE domain containing 1 2.18379
INTS3 integrator complex subunit 3 2.18253
CBX7 chromobox homolog 7 2.17669
TP53BP1 tumor protein p53 binding protein 1 2.17626
DDAH1 dimethylarginine dimethylaminohydrolase 1 2.17413
MAPK7 mitogen-activated protein kinase 7 2.16678
CKB creatine kinase, brain 2.16615
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa 2.1597
CPNE7 copine VII 2.15691
HYOU1 hypoxia up-regulated 1 2.15055
LARP6 La ribonucleoprotein domain family, member 6 2.14918
UCKL1 uridine-cytidine kinase 1-like 1 2.13285
WBP2 WW domain binding protein 2 2.125
PSKH1 protein serine kinase H1 2.11837
PLXNB1 plexin B1 2.11462
POU6F1 POU class 6 homeobox 1 2.11323
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) 2.11199
SYNE2 spectrin repeat containing, nuclear envelope 2 2.10998
PTK2B protein tyrosine kinase 2 beta 2.10984
REEP2 receptor accessory protein 2 2.1062
TIAM1 T-cell lymphoma invasion and metastasis 1 2.10049
CTSD cathepsin D 2.099
RALY RALY heterogeneous nuclear ribonucleoprotein 2.09277
DNM2 dynamin 2 2.09259
SPINT1 serine peptidase inhibitor, Kunitz type 1 2.09219
CAPN1 calpain 1, (mu/I) large subunit 2.08697
HOXA10 homeobox A10 2.0857
ABHD8 abhydrolase domain containing 8 2.07547
AGAP4 ArfGAP with GTPase domain, ankyrin repeat and PH domain 4 2.07111
MDC1 mediator of DNA-damage checkpoint 1 2.06513
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 2.06464
PLXNB2 plexin B2 2.05958
HIP1R huntingtin interacting protein 1 related 2.05359
POLM polymerase (DNA directed), mu 2.05222
WNT6 wingless-type MMTV integration site family, member 6 2.05108
GORASP1 golgi reassembly stacking protein 1, 65kDa 2.04977
DVL2 dishevelled segment polarity protein 2 2.0483
MINK1 misshapen-like kinase 1 2.04703
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 2.04699
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) 2.04394
KLHDC3 kelch domain containing 3 2.04199
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa 2.03911
GAS6 growth arrest-specific 6 2.03725
SIPA1L3 signal-induced proliferation-associated 1 like 3 2.03682
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) 2.03217
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.02991
FPGS folylpolyglutamate synthase 2.02945
MOK MOK protein kinase 2.02377
ZNF358 zinc finger protein 358 2.02102
DMPK dystrophia myotonica-protein kinase 2.02077
DUSP8 dual specificity phosphatase 8 2.0178
RNF126 ring finger protein 126 2.01393
ADGRB2 adhesion G protein-coupled receptor B2 2.00878
ZNF76 zinc finger protein 76 2.00838
TTC38 tetratricopeptide repeat domain 38 2.00659
HBA1 hemoglobin, alpha 1 2.00591
GMPR guanosine monophosphate reductase 2.00359
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 2.00271

decreased expression

Symbol Name Standardized Value
FASTKD5 FAST kinase domains 5 -10.0
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -9.49655
MYC v-myc avian myelocytomatosis viral oncogene homolog -7.41287
WDR7 WD repeat domain 7 -6.18943
CCNB2 cyclin B2 -5.92566
GOLT1B golgi transport 1B -5.78649
ZNF586 zinc finger protein 586 -5.77621
HACD3 3-hydroxyacyl-CoA dehydratase 3 -5.49453
EAPP E2F-associated phosphoprotein -5.27803
LDHD lactate dehydrogenase D -4.81148
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.77678
IER3 immediate early response 3 -4.64754
TXNRD1 thioredoxin reductase 1 -4.62067
PROS1 protein S (alpha) -4.36218
DDIT4 DNA-damage-inducible transcript 4 -4.09627
GET1 guided entry of tail-anchored proteins factor 1 -3.97349
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.89286
EIF5 eukaryotic translation initiation factor 5 -3.87914
YME1L1 YME1-like 1 ATPase -3.8717
CASP3 caspase 3, apoptosis-related cysteine peptidase -3.84288
BLMH bleomycin hydrolase -3.80944
WASHC4 WASH complex subunit 4 -3.76635
SLC25A46 solute carrier family 25, member 46 -3.7507
CDK1 cyclin-dependent kinase 1 -3.72018
CDK6 cyclin-dependent kinase 6 -3.67972
CARMIL1 capping protein regulator and myosin 1 linker 1 -3.67886
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.67519
MAT2A methionine adenosyltransferase II, alpha -3.65757
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -3.6283
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.54445
MRPS16 mitochondrial ribosomal protein S16 -3.43212
GTF2A2 general transcription factor IIA, 2, 12kDa -3.39587
ZDHHC6 zinc finger, DHHC-type containing 6 -3.34002
PRPF4 pre-mRNA processing factor 4 -3.19927
CCNB1 cyclin B1 -3.15412
HEATR1 HEAT repeat containing 1 -3.14919
MELK maternal embryonic leucine zipper kinase -3.07219
NCK1 NCK adaptor protein 1 -3.06394
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -3.04788
TFB2M transcription factor B2, mitochondrial -3.02878
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -3.01908
IDE insulin-degrading enzyme -2.99908
DCK deoxycytidine kinase -2.99626
AKAP8 A kinase (PRKA) anchor protein 8 -2.991
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.97446
OXA1L oxidase (cytochrome c) assembly 1-like -2.95161
ZMIZ1 zinc finger, MIZ-type containing 1 -2.94461
ZW10 zw10 kinetochore protein -2.91782
ENOPH1 enolase-phosphatase 1 -2.87102
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) -2.81379
HAT1 histone acetyltransferase 1 -2.80717
CDC73 cell division cycle 73 -2.79891
LYPLA1 lysophospholipase I -2.7981
GMFB glia maturation factor, beta -2.78216
TRIB1 tribbles pseudokinase 1 -2.77846
PGAM4 phosphoglycerate mutase family member 4 -2.75409
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase -2.74426
HLA-DMA major histocompatibility complex, class II, DM alpha -2.71502
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.69704
KLF10 Kruppel-like factor 10 -2.68373
DYNLT3 dynein, light chain, Tctex-type 3 -2.67915
SMG8 SMG8 nonsense mediated mRNA decay factor -2.67855
CCDC59 coiled-coil domain containing 59 -2.67185
GTPBP8 GTP-binding protein 8 (putative) -2.65288
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.6438
PARP2 poly (ADP-ribose) polymerase 2 -2.63322
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.62911
FADD Fas (TNFRSF6)-associated via death domain -2.61917
ALG8 ALG8, alpha-1,3-glucosyltransferase -2.60055
HSPD1 heat shock 60kDa protein 1 (chaperonin) -2.58842
RGS2 regulator of G-protein signaling 2 -2.58373
ADGRE1 adhesion G protein-coupled receptor E1 -2.58042
RALB v-ral simian leukemia viral oncogene homolog B -2.57825
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.57155
TMX1 thioredoxin-related transmembrane protein 1 -2.56284
UFM1 ubiquitin-fold modifier 1 -2.55666
SRSF3 serine/arginine-rich splicing factor 3 -2.54708
CTSL cathepsin L -2.53129
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -2.50346
ECHDC1 ethylmalonyl-CoA decarboxylase 1 -2.48418
FER fer (fps/fes related) tyrosine kinase -2.47385
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1 -2.43893
CLTC clathrin, heavy chain (Hc) -2.43572
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 -2.42597
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) -2.40107
ZNF207 zinc finger protein 207 -2.39132
ADAM10 ADAM metallopeptidase domain 10 -2.38677
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.37397
STMN1 stathmin 1 -2.36787
NQO2 NAD(P)H dehydrogenase, quinone 2 -2.36483
LOC124907782 dual specificity protein phosphatase 22 -2.36271
VCPKMT valosin containing protein lysine (K) methyltransferase -2.35083
BIRC2 baculoviral IAP repeat containing 2 -2.34727
RBM7 RNA binding motif protein 7 -2.34322
ADO 2-aminoethanethiol (cysteamine) dioxygenase -2.34003
DERA deoxyribose-phosphate aldolase (putative) -2.3321
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 -2.327
HEXIM1 hexamethylene bis-acetamide inducible 1 -2.31745
DUSP6 dual specificity phosphatase 6 -2.30686
TM9SF1 transmembrane 9 superfamily member 1 -2.30101
TMEM135 transmembrane protein 135 -2.2987
CDK4 cyclin-dependent kinase 4 -2.28746
TXNDC9 thioredoxin domain containing 9 -2.28519
PCDHB11 protocadherin beta 11 -2.27761
MCTS1 malignant T cell amplified sequence 1 -2.27404
RAI14 retinoic acid induced 14 -2.26326
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -2.26113
ATF6 activating transcription factor 6 -2.24757
CCNA2 cyclin A2 -2.24126
RNMT RNA (guanine-7-) methyltransferase -2.23524
SBNO1 strawberry notch homolog 1 (Drosophila) -2.22141
ITPRID2 ITPR interacting domain containing 2 -2.21943
PLXDC2 plexin domain containing 2 -2.21322
MAIP1 matrix AAA peptidase interacting protein 1 -2.21145
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.20339
SEH1L SEH1-like (S. cerevisiae) -2.19461
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C -2.17993
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.17862
PWP1 PWP1 homolog (S. cerevisiae) -2.16599
RNF14 ring finger protein 14 -2.15763
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 -2.15711
ALG6 ALG6, alpha-1,3-glucosyltransferase -2.15506
SELENOT selenoprotein T -2.15463
LOC128031832 uncharacterized LOC128031832 -2.14357
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa -2.14112
EPHX3 epoxide hydrolase 3 -2.12393
TRIP4 thyroid hormone receptor interactor 4 -2.12284
NKAPD1 NKAP domain containing 1 -2.10552
TMED7 transmembrane emp24 protein transport domain containing 7 -2.10448
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2 -2.09952
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -2.09518
SELL selectin L -2.09064
SLC61A1 solute carrier family 61 member 1 -2.08778
ARCN1 archain 1 -2.08247
MEX3C mex-3 RNA binding family member C -2.07993
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 -2.07706
SELENOF selenoprotein F -2.07466
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -2.07303
CEP76 centrosomal protein 76kDa -2.06801
GAS7 growth arrest-specific 7 -2.0639
SRP72 signal recognition particle 72kDa -2.06369
ICAM3 intercellular adhesion molecule 3 -2.06229
CRYZ crystallin, zeta (quinone reductase) -2.05727
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -2.05451
SYPL1 synaptophysin-like 1 -2.05393
SIAH1 siah E3 ubiquitin protein ligase 1 -2.05217
LOC124906748 beta-defensin 4A -2.04858
SCFD1 sec1 family domain containing 1 -2.03752
RBM4 RNA binding motif protein 4 -2.02601
BECN1 beclin 1, autophagy related -2.01806
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -2.01796
DOLK dolichol kinase -2.01595
SERTAD2 SERTA domain containing 2 -2.01109
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) -2.00913
HMGA2 high mobility group AT-hook 2 -2.00911
SRP54 signal recognition particle 54kDa -2.00793
ZNF184 zinc finger protein 184 -2.0065
RTRAF RNA transcription, translation and transport factor -2.00576
MED7 mediator complex subunit 7 -2.00305